Results 81 to 90 of about 116,348 (354)

Self‐Adjusting Engineered Probiotic for Targeted Tumor Colonization and Local Therapeutics Delivery

Advanced Science, EarlyView.
Zou et al. developed an engineered strain of Escherichia coli Nissle 1917 with precise targeting abilities for colonization and on‐demand payload release. The engineered probiotic survives and embolizes tumors only in the presence of more than 5 mM L‐lactate. Furthermore, the introduction of an α‐hemolysin circuit enhances its anti‐tumor effect.
Zhen‐Ping Zou, Xin‐Ge Wang, Xuan‐Ren Shi, Shu‐Ting Sun, Jing Mi, Xiao‐Peng Zhang, Bin‐Cheng Yin, Ying Zhou, Bang‐Ce Ye   +8 more
wiley   +1 more source

l-Arabinose improves hypercholesterolemia via regulating bile acid metabolism in high-fat-high-sucrose diet-fed mice

Nutrition & Metabolism, 2022
Background Hypercholesterolemia is closely associated with an increased risk of cardiovascular diseases. l-Arabinose exhibited hypocholesterolemia properties, but underlying mechanisms have not been sufficiently investigated.
Yu Wang, Jiajia Zhao, Qiang Li, Jinxin Liu, Yujie Sun, Kuiliang Zhang, Mingcong Fan, Haifeng Qian, Yan Li, Li Wang   +9 more
doaj   +1 more source

Metabolic Engineering for Improved Fermentation of L-Arabinose.

Journal of Microbiology and Biotechnology, 2019
L-Arabinose, a five carbon sugar, has not been considered as an important bioresource because most studies have focused on D-xylose, another type of five-carbon sugar that is prevalent as a monomeric structure of hemicellulose.
S. Ye, Jeong-won Kim, S. Kim
semanticscholar   +1 more source

Development of novel orthogonal genetic circuits, based on extracytoplasmic function (ECF) σ factors [PDF]

, 2019
The synthetic biology field aims to apply the engineering 'design-build-test-learn' cycle for the implementation of synthetic genetic circuits modifying the behavior of biological systems. In order to reach this goal, synthetic biology projects use a set
Vecchione, Stefano
core   +1 more source

Alistipes senegalensis is Critically Involved in Gut Barrier Repair Mediated by Panax Ginseng Neutral Polysaccharides in Aged Mice

Advanced Science, EarlyView.
An integral functional axis through which GPN and functional metabolites of Alistipes senegalensis can hydrolyze tryptophan into indoles. Furthermore, the Alistipes senegalensis‐indole‐AhR pathway is found to be associated with increased expression of tight junction‐associated proteins and activation of gut stem cells.
Dandan Wang, Hui Wang, Yingna Li, Jing Lu, Xiaolei Tang, Dan Yang, Manying Wang, Daqing Zhao, Fangbing Liu, Shuai Zhang, Liwei Sun   +10 more
wiley   +1 more source

Process optimization and kinetics of arabinose preparation by dilute acid hydrolysis

Shipin yu jixie, 2023
Objective: Preferred biomass hydrolysis for preparation of arabinose and its kinetic analysis during the hydrolysis process. Methods: Single factor experiment and response surface methodology were used to optimize the conditions for the preparation of ...
TIAN Long, TONG Fen-fei
doaj   +1 more source

L-arabinose metabolism in Azospirillum brasiliense [PDF]

Journal of Bacteriology, 1982
An oxidative pathway by which L-arabinose is converted to alpha-ketoglutarate in crude extracts of Azospirillum brasiliense is demonstrated. Specific activities of enzymes involved in the pathway were determined, and several pathway intermediates were identified.
N J Novick, M E Tyler
openaire   +3 more sources

Using cellular fitness to map the structure and function of a major facilitator superfamily effluxer. [PDF]

, 2017
The major facilitator superfamily (MFS) effluxers are prominent mediators of antimicrobial resistance. The biochemical characterization of MFS proteins is hindered by their complex membrane environment that makes in vitro biochemical analysis challenging.
Bennett, Matthew R, Gomez, Marcella M, Kalvapalle, Prashant, O'Brien-Gilbert, Erin, Perez, Anisha M, Shamoo, Yousif   +5 more
core   +2 more sources

Bacteria Optimize Tumble Bias to Strategically Navigate Surface Constraints

Advanced Science, EarlyView.
The study investigates how Escherichia coli optimizes tumble bias (TB) to navigate surface constraints effectively. Using single‐cell tracking and modeling, it reveals that bacterial surface residence time decreases with increasing TB, stabilizing near the wild‐type mean TB (≈0.25), where surface diffusivity peaks.
Antai Tao, Guangzhe Liu, Rongjing Zhang, Junhua Yuan   +3 more
wiley   +1 more source

Targeted Intervention Strategies for Maternal–Offspring Transmission of Christensenellaceae in Pigs via a Deep Learning Model

Advanced Science, EarlyView.
This study deciphers maternal‐driven microbial transmission in pigs using a deep learning model (maternal–offspring microbial transmission model), identifying Christensenellaceae R‐7 group as a key transmitted taxon. Filtered galacto‐oligosaccharides‐targeted Christensenellaceae R‐7 group alters offspring microbial functions via maternal ...
Haibo Shen, Xiaokang Ma, Longlin Zhang, Hao Li, Jichang Zheng, Shengru Wu, Ke Zuo, Yulong Yin, Jing Wang, Bie Tan   +9 more
wiley   +1 more source