Results 121 to 130 of about 17,329 (193)

Biological evaluation and molecular Docking studies of the prepared chalcone derivatives as potential anti-Alzheimer agents. [PDF]

Sci Rep
Agbo EN, Maluleke BK, Gildenhuys S, Leboho TC, Nxumalo W.   +4 more
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Bioactive compounds in the modulation of oxidative stress in monocytes and macrophages. [PDF]

Sci Rep
Kushwaha R, Alugoju P, Anthikapalli NVA, Sharma R, Sedlářová M, Pospíšil P, Tamasi G, Bonechi C, Rossi C, Prasad A.   +9 more
europepmc   +1 more source

Helminth-induced prostaglandin signaling and dietary shifts in PUFA metabolism promote colitis-associated cancer. [PDF]

J Lipid Res
Smith KA, Reed EK, Guschina I, Tyrrell VJ, Butters C, Darby MG, Katsandegwaza B, Chetty A, Horsnell WGC, O'Donnell VB, Gallimore A.   +10 more
europepmc   +1 more source

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Localization of arachidonate 12-lipoxygenase in canine brain tissues

Neuroscience Research Supplements, 1991
Abstract: The cytosol fraction from a thoroughly imgated canine cerebrum was subjected to immunoaffinity chromatography using a monoclonal antibody against porcine leukocyte 12‐lipoxygenase. Arachidonate 12‐lipoxygenase eluted from the column with some retardation. The enzyme, with a specific activity of 9 nmol/min/mg of protein, converted arachidonic
M, Nishiyama, H, Okamoto, T, Watanabe, T, Hori, T, Hada, N, Ueda, S, Yamamoto, H, Tsukamoto, K, Watanabe, T, Kirino   +9 more
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Eicosanoid regulation of angiogenesis: role of endothelial arachidonate 12-lipoxygenase

Blood, 2000
Angiogenesis, the formation of new capillaries from preexisting blood vessels, is a multistep, highly orchestrated process involving vessel sprouting, endothelial cell migration, proliferation, tube differentiation, and survival. Eicosanoids, arachidonic acid (AA)-derived metabolites, have potent biologic activities on vascular endothelial cells ...
D, Nie, K, Tang, C, Diglio, K V, Honn
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Molecular cloning and expression of human arachidonate 12-lipoxygenase

Biochemical and Biophysical Research Communications, 1990
The cDNA for a 12-lipoxygenase was isolated from cDNA library of human erythroleukemia cells. The cDNA had an open reading frame encoding 663 amino acids with a calculated molecular weight of 75,513. The deduced amino acid sequence of human 12-lipoxygenase exhibited 41.5%, 65.3% and 65.4% identity with human 5-lipoxygenase, human 15-lipoxygenase and ...
T, Yoshimoto, Y, Yamamoto, T, Arakawa, H, Suzuki, S, Yamamoto, C, Yokoyama, T, Tanabe, H, Toh   +7 more
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Arachidonate 12-Lipoxygenase Isozymes

Advances in Experimental Medicine and Biology, 1999
A lipoxygenase is an enzyme which incorporates one molecule of oxygen into arachidonic acid or other polyunsaturated fatty acids producing hydroperoxy acids with a conjugated diene system. Enzymes oxygenating at the positions 5, 8, 12 and 15 of arachidonic acid and producing the corresponding hydroperoxy eicosatetraenoic acid (HpETE) have been isolated
S, Yamamoto, H, Suzuki, M, Nakamura, K, Ishimura   +3 more
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Partial purification and characterization of arachidonate 12-lipoxygenase from rat lung

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1983
Incubation of rat lung cytosol with arachidonic acid produced 12-hydroxy-5,8,10,14-eicosatetraenoic acid as a major product, which was identified by gas chromatography-mass spectrometry. By ammonium sulfate fractionation and DEAE-cellulose chromatography the arachidonate 12-lipoxygenase was purified about 30-fold from the rat lung cytosol.
C, Yokoyama, K, Mizuno, H, Mitachi, T, Yoshimoto, S, Yamamoto, C R, Pace-Asciak   +5 more
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Lipoxin synthesis by arachidonate 12-lipoxygenase purified from porcine leukocytes

Biochemical and Biophysical Research Communications, 1987
Arachidonate 12-lipoxygenase purified from porcine leukocytes shows 14R-oxygenase and 14, 15-leukotriene A synthase activities with 15-hydroperoxy-arachidonic acid as substrate. The enzyme transformed 5, 15-dihydroperoxy-arachidonic acid to several compounds with a conjugated tetraene. A major product was identified as 5S, 14R, 15S-trihydroperoxy-6, 10,
N, Ueda, C, Yokoyama, S, Yamamoto, B J, Fitzsimmons, J, Rokach, J A, Oates, A R, Brash   +6 more
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Arachidonate 12-lipoxygenase of porcine leukocyte with activity for 5-hydroxyeicosatetraenoic acid

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1982
When arachidonic acid was incubated with porcine polymorphonuclear leukocytes, 12-hydroxy-5,8,10,14-eicosatetraenoic acid was produced as a major product. The production of this compound was not accounted for by contaminating platelets known to contain arachidonate 12-lipoxygenase. The enzyme was found predominantly in a cytosol fraction of leukocytes,
T, Yoshimoto, Y, Miyamoto, K, Ochi, S, Yamamoto   +3 more
openaire   +3 more sources