Results 1 to 10 of about 402 (97)

Contrasting in vitro lymphocyte chemotactic activity of the hydroxyl enantiomers of 12-hydroxy-5,8,10,14-eicosatetraenoic acid. [PDF]

Br J Pharmacol, 1988
The chemotactic activity of 12(R)‐hydroxy‐5,8,10,14‐eicosatetraenoic acid (12(R)‐HETE), 12(S)‐HETE and leukotriene B4 (LTB4) for human mixed peripheral blood lymphocytes has been assessed in a 48‐well microchemotaxis assay. Responses to the standard lymphocyte chemoattractants, zymosan‐activated plasma, casein and N‐formyl‐methionyl‐leucyl ...
Bacon KB, Camp RD, Cunningham FM, Woollard PM.   +3 more
europepmc   +4 more sources

Metabolomics reveals pro-inflammatory effects of 12R-HETE and ALOX12B in maternal allergic asthma [PDF]

Communications Biology
Approximately 10% of pregnant women worldwide suffer from asthma, significantly increasing risks like preterm birth, low birth weight, and gestational hypertension. Current diagnostic methods are limited in early detection, underscoring the need for more
Liyuan Wang, Xuan Wang, Wenying Wang, Zhengpeng Sun, Huafeng Fang, Chongjun Qi, Wei Lin, Lili Lin, Tong Xie, Cunsi Shen, Chen Shi, Jianya Xu, Feng Ge, Jinjun Shan   +13 more
doaj   +2 more sources

Deactivation of 12(S)-HETE through (ω-1)-hydroxylation and β-oxidation in alternatively activated macrophages [PDF]

Journal of Lipid Research, 2018
Polarization of macrophages to proinflammatory M1 and to antiinflammatory alternatively activated M2 states has physiological implications in the development of experimental hypertension and other pathological conditions.
Tamas Kriska, Michael J. Thomas, John R. Falck, William B. Campbell   +3 more
doaj   +2 more sources

ATP antagonizes thrombin-induced signal transduction through 12(S)-HETE and cAMP. [PDF]

PLoS ONE, 2013
In this study we have investigated the role of extracellular ATP on thrombin induced-platelet aggregation (TIPA) in washed human platelets. ATP inhibited TIPA in a dose-dependent manner and this inhibition was abolished by apyrase but not by adenosine ...
Jaione Burzaco, Manuel Conde, Luis A Parada, José L Zugaza, Jean-Paul Dehaye, Aida Marino   +5 more
doaj   +1 more source

Metabolism of 12(S)-hydroxy-5,8,10,14-eicosatetraenoic acid by kidney and liver peroxisomes.

Journal of Lipid Research, 1993
12(S)-Hydroperoxy-5,8,10,14-eicosatetraenoic acid (12(S)-HPETE) is one of the main products formed from arachidonic acid by animal lipoxygenases. It is usually reduced to the corresponding hydroxy acid, 12(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12(S)
J Wigren, H Herbertsson, O Tollbom, S Hammarström   +3 more
doaj   +1 more source

Cutaneous Responses to 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid (12-HETE)

Journal of Investigative Dermatology, 1985
The responses to 12-HETE in normal human skin have been investigated by means of intradermal and topical administration in 15 subjects. Intradermal infusion of 12-HETE produced a neutrophil polymorphonuclear and mononuclear infiltrate in the dermis. Topical administration resulted in a dose-related erythematous response to 200 ng-50 micrograms.
Dowd, Pauline M., Black, Anne Kobza, Woollard, Patrick M., Camp, Richard D R, Greaves, Malcolm W.   +4 more
openaire   +2 more sources

Identification of subunits of the 650 kDa 12(S)-HETE binding complex in carcinoma cells

Journal of Lipid Research, 1998
Cytosol and nuclei of Lewis lung carcinoma (LLC) cells contain high affinity binding sites specific for the arachidonic acid metabolite 12(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12(S)-HETE). In this report we present evidence that the cytosolic 12(S)
Helena Herbertsson, Tobias Kühme, Ulrika Evertsson, Jane Wigren, Sven Hammarström   +4 more
doaj   +1 more source

Antiplatelet Effect of NQ12: a Possible Mechanism Through the Arachidonic Acid Cascade

Journal of Pharmacological Sciences, 2007
NQ12, an antithrombotic agent, has been reported to display a potent antiplatelet activity. This study was undertaken to reveal the effect of NQ12 on rabbit platelet aggregation and signal transduction involved in the arachidonic acid (AA) cascade.
Yong-Ri Jin, Xiang-Hua Han, Jung-Jin Lee, Yong Lim, Tack-Joong Kim, Hwan-Soo Yoo, Jin-Tae Hong, Chong-Kil Lee, Yeo-Pyo Yun   +8 more
doaj   +1 more source

Natural Products for Antithrombosis

Evidence-Based Complementary and Alternative Medicine, Volume 2015, Issue 1, 2015., 2015
Thrombosis is considered to be closely related to several diseases such as atherosclerosis, ischemic heart disease and stroke, as well as rheumatoid arthritis, hyperuricemia, and various inflammatory conditions. More and more studies have been focused on understanding the mechanism of molecular and cellular basis of thrombus formation as well as ...
Cen Chen, Feng-Qing Yang, Qian Zhang, Feng-Qin Wang, Yuan-Jia Hu, Zhi-Ning Xia, Angelo A. Izzo   +6 more
wiley   +1 more source

Blood Level Omega‐3 Fatty Acids as Risk Determinant Molecular Biomarker for Prostate Cancer

Prostate Cancer, Volume 2013, Issue 1, 2013., 2013
Previous researches involving dietary methods have shown conflicting findings. Authors sought to assess the association of prostate cancer risk with blood levels of omega‐3 polyunsaturated fatty acids (n‐3 PUFA) through a meta‐analysis of human epidemiological studies in available online databases (July, 2012).
Mishell Kris Sorongon-Legaspi, Michael Chua, Maria Christina Sio, Marcelino Morales Jr., Jostein Halgunset   +4 more
wiley   +1 more source