Results 1 to 10 of about 5,706 (177)

5-Lipooxygenase Derivatives as Serum Biomarkers of a Successful Dietary Intervention in Patients with NonAlcoholic Fatty Liver Disease

Medicina, 2020
Background: It was previously shown that a bodyweight reduction among patients with nonalcoholic fatty liver (NAFLD) was connected to the lower concentration of arachidonic and linoleic acid derivatives in their blood.
Marcin Banaszczak, Dominika Maciejewska, Arleta Drozd, Karina Ryterska, Dominika Jamioł Milc, Joanna Raszeja-Wyszomirska, Ewa Wunsch, Pedro González-Muniesa, Ewa Stachowska   +8 more
doaj   +1 more source

Glucuronidation of arachidonic and linoleic acid metabolites by human UDP-glucuronosyltransferases

Journal of Lipid Research, 2003
Arachidonic acids (AA) and linoleic acids (LAs) are metabolized, in several tissues, to hydroxylated metabolites that are important mediators of many physiological and pathophysiological processes.
David Turgeon, Sarah Chouinard, Patrick Bélanger, Serge Picard, Jean-François Labbé, Pierre Borgeat, Alain Bélanger   +6 more
doaj   +1 more source

Effect of Different Omega-6/Omega-3 Polyunsaturated Fatty Acid Ratios on the Formation of Monohydroxylated Fatty Acids in THP-1 Derived Macrophages

Biology, 2015
Omega-6 and omega-3 polyunsaturated fatty acids (n-6 and n-3 PUFA) can modulate inflammatory processes. In western diets, the content of n-6 PUFA is much higher than that of n-3 PUFA, which has been suggested to promote a pro-inflammatory phenotype.
Kathrin Keeren, Dan Huang, Christopher Smyl, Andreas Fischer, Michael Rothe, Karsten-H. Weylandt   +5 more
doaj   +1 more source

miR-18a promotes glioblastoma development by down-regulating ALOXE3-mediated ferroptotic and anti-migration activities

Oncogenesis, 2021
The development of glioblastoma (GBM) is typically accompanied by marked changes in lipid metabolism. Oxylipins and their catalyzed enzymes lipoxygenases (LOXs) have been shown to participate in the development of cancers via multiple pathways, while the
Xinzhi Yang, Jiangang Liu, Chenci Wang, Kenneth King-yip Cheng, Hongchao Xu, Qingzhong Li, Tian Hua, Xue Jiang, Lili Sheng, Jie Mao, Zhuohao Liu   +10 more
doaj   +1 more source

Quantitative Profiling of Hydroxy Lipid Metabolites in Mouse Organs Reveals Distinct Lipidomic Profiles and Modifications Due to Elevated n-3 Fatty Acid Levels

Biology, 2017
Polyunsaturated fatty acids (PUFA) are precursors of bioactive metabolites and mediators. In this study, the profile of hydroxyeicosatetraenoic (HETE), hydroxyeicosapentaenoic (HEPE) and hydroxydocosahexaenoic (HDHA) acids derived from arachidonic acid ...
Cheng-Ying Chiu, Christopher Smyl, Inci Dogan, Michael Rothe, Karsten-H. Weylandt   +4 more
doaj   +1 more source

Metabolomics of Clinical Poisoning by Aconitum Alkaloids Using Derivatization LC-MS

Frontiers in Pharmacology, 2019
The root of Aconitum kusnezoffii (Caowu in Chinese, CW) is not only commonly used as a traditional Chinese medicine (TCM), but also served as a tonic in China. Due to its high toxicity, clinical poisoning cases induced by CW have frequently been reported.
Yida Zhang, Xiqing Bian, Jing Yang, Haiying Wu, Jian-Lin Wu, Na Li   +5 more
doaj   +1 more source

Epoxyeicosatrienoic Acids and 20-Hydroxyeicosatetraenoic Acid on Endothelial and Vascular Function [PDF]

, 2016
Endothelial and vascular smooth cells generate cytochrome P450 (CYP) arachidonic acid metabolites that can impact endothelial cell function and vascular homeostasis. The objective of this review is to focus on the physiology and pharmacology of endothelial CYP metabolites.
openaire   +2 more sources

Amniotic fluid 5-hydroxyeicosatetraenoic acid in preterm labor

Prostaglandins, 1988
5-Hydroxyeicosatetraenoic acid (5-HETE) is an arachidonate lipoxygenase product capable of stimulating human uterine contractility in a dose-dependent manner in vitro. The purpose of this study was to determine if preterm labor is associated with changes in the concentration of this metabolite in amniotic fluid.
Romero, Roberto, Wu, Ying King, Mazor, Moshe, Hobbins, John C., Mitchell, Murray D.   +4 more
openaire   +5 more sources

Altered Protein Expression of Cardiac CYP2J and Hepatic CYP2C, CYP4A, and CYP4F in a Mouse Model of Type II Diabetes—A Link in the Onset and Development of Cardiovascular Disease?

Pharmaceutics, 2017
Arachidonic acid can be metabolized by cytochrome P450 (CYP450) enzymes in a tissue- and cell-specific manner to generate vasoactive products such as epoxyeicosatrienoic acids (EETs-cardioprotective) and hydroxyeicosatetraenoic acids (HETEs-cardiotoxic).
Benoit Drolet, Sylvie Pilote, Carolanne Gélinas, Alida-Douce Kamaliza, Audrey Blais-Boilard, Jessica Virgili, Dany Patoine, Chantale Simard   +7 more
doaj   +1 more source

Renal Ischemia/Reperfusion Injury in Soluble Epoxide Hydrolase-Deficient Mice. [PDF]

PLoS ONE, 2016
AIM:20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs) are cytochrome P450 (CYP)-dependent eicosanoids that play opposite roles in the regulation of vascular tone, inflammation, and apoptosis.
Ye Zhu, Maximilian Blum, Uwe Hoff, Tim Wesser, Mandy Fechner, Christina Westphal, Dennis Gürgen, Rusan Ali Catar, Aurelie Philippe, Kaiyin Wu, Gordana Bubalo, Michael Rothe, Steven M Weldon, Duska Dragun, Wolf-Hagen Schunck   +14 more
doaj   +1 more source