Results 21 to 30 of about 5,706 (177)
Roles of hydroxyeicosatetraenoic acids in diabetes (HETEs and diabetes)
Biomedicine & Pharmacotherapy, 2022 Hydroxyeicosatetraenoic acids (HETEs) are metabolites of arachidonate acid (AA) oxidized by lipoxygenases or cytochrome P450 enzymes (CYP450). Since lipoxygenases and CYP450 enzymes widely exist in different organs and tissues, HETEs play significant roles in normal physiological and pathophysiological conditions. Mounting evidence has shown that HETEs
Linyue, Dong +3 more
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Expression and Function of Eicosanoid-Producing Cytochrome P450 Enzymes in Solid Tumors
Frontiers in Pharmacology, 2020 Oxylipins derived from the oxidation of polyunsaturated fatty acids (PUFAs) act as important paracrine and autocrine signaling molecules. A subclass of oxylipins, the eicosanoids, have a broad range of physiological outcomes in inflammation, the immune ...
Eric A. Evangelista +3 more
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Pleiotropic Functions of Cytochrome P450 Monooxygenase-Derived Eicosanoids in Cancer
Frontiers in Pharmacology, 2020 Eicosanoids are a class of functionally bioactive lipid mediators derived from the metabolism of long-chain polyunsaturated fatty acids (PUFAs) mediated by multiple enzymes of three main branches, including cyclooxygenases (COXs), lipoxygenases (LOXs ...
Ying Luo, Jun-Yan Liu
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Biomolecules, 2022 Pathogen inactivation techniques for blood products have been implemented to optimize clinically safe blood components supply. The INTERCEPT system uses amotosalen together with ultraviolet light wavelength A (UVA) irradiation.
Gerda C. Leitner +11 more
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Metabolism of oxygenated derivatives of arachidonic acid by Caco-2 cells.
Journal of Lipid Research, 1992 Monolayers of Caco-2 cells, a human enterocyte cell line, were incubated separately with 3H8-labeled preparations of three different lipid mediators of inflammation: 5-hydroxyeicosatetraenoic acid, 12-hydroxyeicosatetraenoic acid, and leukotriene B4 ...
TE Riehl, J Turk, WF Stenson
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Metabolism of 15-hydroxyeicosatetraenoic acid by Caco-2 cells.
Journal of Lipid Research, 1990 Monolayers of Caco-2 cells, a human enterocyte cell line, were incubated with [1-14C]15-hydroxyeicosatetraenoic acid (15-HETE), a lipid mediator of inflammation, and [1-14C]arachidonic acid.
TE Riehl, NM Bass, WF Stenson
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Identification of hydroxyeicosatetraenoic acid components of schistosomal hemozoin [PDF]
Biochemical and Biophysical Research Communications, 2007 During the late stages of Schistosoma mansoni infection, adult schistosomes catabolize host erythrocytic hemoglobin. In order to evade the toxic effects of free heme, the blood fluke biomineralizes dimeric heme into an inert crystalline pigment called hemozoin.
Melissa D, Carter +2 more
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Analysis of HETEs in human whole blood by chiral UHPLC-ECAPCI/HRMS
Journal of Lipid Research, 2018 The biosynthesis of eicosanoids occurs enzymatically via lipoxygenases, cyclooxygenases, and cytochrome P450, or through nonenzymatic free radical reactions. The enzymatic routes are highly enantiospecific.
Liudmila L. Mazaleuskaya +6 more
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Journal of Lipid Research, 2006 Eicosanoids participate in the regulation of cellular proliferation. Thus, we observed that prostaglandin E2 interaction with membrane receptors is involved in the control of 3T6 fibroblast growth induced by serum.
Diana Nieves, Juan JoseĢ Moreno
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A high throughput screen identifies potent and selective inhibitors to human epithelial 15-lipoxygenase-2. [PDF]
PLoS ONE, 2014 Lipoxygenase (LOX) enzymes catalyze the hydroperoxidation of arachidonic acid and other polyunsaturated fatty acids to hydroxyeicosatetraenoic acids with varying positional specificity to yield important biological signaling molecules.
J Brian Jameson +8 more
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