Results 41 to 50 of about 5,706 (177)

Stabilization and improved activity of arachidonate 11S-lipoxygenase from proteobacterium Myxococcus xanthus

Journal of Lipid Research, 2018
Lipoxygenases (LOXs) catalyze the dioxygenation of PUFAs to produce regio- and stereospecific oxygenated fatty acids. The identification of regio- and stereospecific LOXs is important because their specific products are involved in different ...
Jung-Ung An, Deok-Kun Oh
doaj   +1 more source

Bone-Targeted Delivery of Novokinin as an Alternative Treatment Option for Rheumatoid Arthritis

Pharmaceutics, 2022
Rheumatoid arthritis (RA) is an autoimmune inflammatory bone destructive disorder that is orchestrated by multiple systems in the body, including Renin-Angiotensin System (RAS) and arachidonic acid (ArA) pathway.
Arina Ranjit, Sana Khajeh pour, Ali Aghazadeh-Habashi   +2 more
doaj   +1 more source

Individual variation in lipidomic profiles of healthy subjects in response to omega-3 Fatty acids. [PDF]

PLoS ONE, 2013
INTRODUCTION:Conflicting findings in both interventional and observational studies have resulted in a lack of consensus on the benefits of ω3 fatty acids in reducing disease risk. This may be due to individual variability in response.
Malin L Nording, Jun Yang, Katrin Georgi, Christine Hegedus Karbowski, J Bruce German, Robert H Weiss, Ronald J Hogg, Johan Trygg, Bruce D Hammock, Angela M Zivkovic   +9 more
doaj   +1 more source

Epoxyeicosatrienoic acids, 20-hydroxyeicosatetraenoic acid, and renal microvascular function [PDF]

Prostaglandins & Other Lipid Mediators, 2013
The development of pharmacological, genetic, and biochemical tools have allowed for detailed studies to determine the contribution of cytochrome P450 (CYP) metabolites of arachidonic acid to renal microvascular function. Renal microvessels can generate CYP hydroxylase metabolites including 20-hydroxyeicosatetraenoic acid (20-HETE) and CYP epoxygenase ...
openaire   +2 more sources

Renal 20-hydroxyeicosatetraenoic acid synthesis during pregnancy [PDF]

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2002
We examined whether renal 20-hydroxyeicosatetraenoic acid (20-HETE) synthesis is altered during gestation. Renal microsomal arachidonic acid ω-hydroxylase activity increased by 50 and 48% in rats on days 12 and 19 of gestation, respectively. Renal microvessel 20-HETE synthesis increased by 50 and 82% in rats on days 6 and 12 of gestation, respectively,
Mong-Heng, Wang, Barbara A, Zand, Alberto, Nasjletti, Michal, Laniado-Schwartzman   +3 more
openaire   +2 more sources

A Comprehensive Study of Bidirectional Interactions Between the Human Microbiome and Blood Malignancies and Hematologic Conditions: Focus on Novel Therapeutic Strategies

Journal of Clinical Laboratory Analysis, EarlyView.
Microbiota‐targeted therapeutic strategies in hematological disorders. aHSCT: Transplanted immune cells from the donor may attack the recipient's tissues, especially when damage to the intestinal epithelium disrupts the gut microbiota, contributing to GVHD. Maintaining a balanced gut microbiota that supports immune regulation helps reduce GVHD risk and
Alireza Molajafari, Hadi Sedigh Ebrahim‐Saraie, Majid Taati Moghadam, Meysam Hasannejad‐Bibalan   +3 more
wiley   +1 more source

Deuterated Arachidonic Acids Library for Regulation of Inflammation and Controlled Synthesis of Eicosanoids: An In Vitro Study

Molecules, 2018
The synthesis of signal lipids, including eicosanoids, is not fully understood, although it is key to the modulation of various inflammatory states.
Dmitry V. Chistyakov, Ivan S. Filimonov, Nadezhda V. Azbukina, Sergei V. Goriainov, Viktor V. Chistyakov, Maksim A. Fomich, Andrei V. Bekish, Vadim V. Shmanai, Marina G. Sergeeva, Mikhail S. Shchepinov   +9 more
doaj   +1 more source

Eicosanoids in Nonalcoholic Fatty Liver Disease (NAFLD) Progression. Do Serum Eicosanoids Profile Correspond with Liver Eicosanoids Content during NAFLD Development and Progression?

Molecules, 2020
Nonalcoholic fatty liver disease (NAFLD) is becoming a major public health problem worldwide. The study aimed to evaluate the concentration of eicosanoids in serum and liver tissue during steatosis progression and to assess whether eicosanoid change ...
Dominika Maciejewska, Arleta Drozd, Karolina Skonieczna-Żydecka, Marta Skórka-Majewicz, Karolina Dec, Karolina Jakubczyk, Anna Pilutin, Ewa Stachowska   +7 more
doaj   +1 more source

Blood metabolic fingerprinting of rats, subjected to subchronic lead exposure

Public Health and Toxicology, 2021
Introduction Environmental pollution with heavy metals is vital issue in the present time. Lead, as one of the environmental contaminators, deserves attention due to its applicability in human activity and its xenobiotic character. Methods In this study
Aleksei I. Chemezov, Marina P. Sutunkova, Ilzira A. Minigalieva, Svetlana V. Klinova, Iulia V. Ryabova   +4 more
doaj   +1 more source

Metabolome Diversity Enhances Resistance of Intertidal Clams to Thermal Stress

Integrative Zoology, EarlyView.
Meretrix species are widely distributed intertidal bivalves in China with significant ecological and economic importance, which are sensitive to thermal stress. Our results showed that thermal environments of clam habitats shaped metabolome diversity, which can enhance the resistance of intertidal clams to thermal stress.
Zhi Hu, Xiang‐Tao Wei, Xiaonie Lin, Linxuan Ma, Tianzhe Zhang, Yunwei Dong   +5 more
wiley   +1 more source