Results 31 to 40 of about 5,706 (177)

Hemodialysis and erythrocyte epoxy fatty acids

Physiological Reports, 2020
Fatty acid products derived from cytochromes P450 (CYP) monooxygenase and lipoxygenase (LOX)/CYP ω/(ω‐1)‐hydroxylase pathways are a superclass of lipid mediators with potent bioactivities.
Benjamin Gollasch, Guanlin Wu, Tong Liu, Inci Dogan, Michael Rothe, Maik Gollasch, Friedrich C. Luft   +6 more
doaj   +1 more source

Alcohol produces distinct hepatic lipidome and eicosanoid signature in lean and obese[S]

Journal of Lipid Research, 2016
Alcohol- and obesity-related liver diseases often coexist. The hepatic lipidomics due to alcohol and obesity interaction is unknown. We characterized the hepatic lipidome due to 1) alcohol consumption in lean and obese mice and 2) obesity and alcohol ...
Puneet Puri, Jun Xu, Terhi Vihervaara, Riikka Katainen, Kim Ekroos, Kalyani Daita, Hae-Ki Min, Andrew Joyce, Faridoddin Mirshahi, Hidekazu Tsukamoto, Arun J. Sanyal   +10 more
doaj   +1 more source

19-Hydroxyeicosatetraenoic acid analogs: Antagonism of 20-hydroxyeicosatetraenoic acid-induced vascular sensitization and hypertension

Bioorganic & Medicinal Chemistry Letters, 2019
19-Hydroxyeicosatetraenoic acid (19-HETE, 1), a metabolically and chemically labile cytochrome P450 eicosanoid, has diverse biological activities including antagonism of the vasoconstrictor 20-hydroxyeicosatetraenoic acid (20-HETE, 2). A SAR study was conducted to develop robust analogs of 1 with improved in vitro and in vivo efficacy.
Rambabu Dakarapu, Ramu Errabelli, Vijaya L. Manthati, Adeniyi Michael Adebesin, Deb K. Barma, Deepan Barma, Victor Garcia, Fan Zhang, Michal Laniado Schwartzman, John R. Falck   +9 more
openaire   +3 more sources

20-Hydroxyeicosatetraenoic Acid and Angiotensin [PDF]

Hypertension, 2010
Arachidonic acid metabolites generated by cytochrome P450 (CYP) enzymes are now recognized as contributing importantly to vascular function and blood pressure regulation.1 CYP4A enzymes act as hydroxylases converting arachidonic acid to hydroxyeicosatetraenoic acids (HETEs), with 20-HETE being the major product.
openaire   +1 more source

Proteinuria increases oxylipid concentrations in VLDL and HDL but not LDL particles in the rat

Journal of Lipid Research, 2007
We previously established that proteinuria alters the apolipoprotein content of lipoproteins. This study was conducted to establish whether proteinuria also alters the concentrations of oxidized lipids within lipoprotein density fractions.
John W. Newman, George A. Kaysen, Bruce D. Hammock, Gregory C. Shearer   +3 more
doaj   +1 more source

Race‐based and sex‐based differences in bioactive lipid mediators after myocardial infarction

ESC Heart Failure, 2020
Aims Leucocyte‐directed specialized pro‐resolving mediators (SPMs) are essential for cardiac repair, and their biosynthesis coincides with the expression of pro‐inflammatory mediators; however, the precise quantitation during an acute myocardial ...
Ganesh V. Halade, Vasundhara Kain, Chrisly Dillion, Mark Beasley, Tanja Dudenbostel, Suzanne Oparil, Nita A. Limdi   +6 more
doaj   +1 more source

Cellular Oxygenation of 12-Hydroxyeicosatetraenoic Acid and 15-Hydroxyeicosatetraenoic Acid by 5-Lipoxygenase Is Stimulated by 5-Lipoxygenase-activating Protein [PDF]

Journal of Biological Chemistry, 1998
It has been proposed that 5-lipoxygenase (5-LO)-activating protein (FLAP) is an arachidonate transfer protein for leukotriene biosynthesis. Using the Spodoptera frugiperda (Sf9) insect cells, we demonstrate that FLAP causes a large stimulation (190-fold) of the conversion of 12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE) to 5, 12-diHETE when co ...
J A, Mancini, H, Waterman, D, Riendeau
openaire   +2 more sources

Preparation of 20-HETE using multifunctional enzyme type 2-negative Starmerella bombicola[S]

Journal of Lipid Research, 2013
The metabolism of arachidonic acid (ARA) by cytochrome P450 ω/ω-1-hydroxylases leads to the formation of 20-hydroxyeicosatetraenoic acid (20-HETE), which is an important lipid-signaling molecule involved in regulation of vascular tone, angiogenesis, and ...
Inge Van Bogaert, Guodong Zhang, Jun Yang, Jun-Yan Liu, Yonghao Ye, Wim Soetaert, Bruce D. Hammock   +6 more
doaj   +1 more source

Membrane Lipid Derivatives: Roles of Arachidonic Acid and Its Metabolites in Pancreatic Physiology and Pathophysiology

Molecules, 2023
One of the most important constituents of the cell membrane is arachidonic acid. Lipids forming part of the cellular membrane can be metabolized in a variety of cellular types of the body by a family of enzymes termed phospholipases: phospholipase A2 ...
Cándido Ortiz-Placín, Alba Castillejo-Rufo, Matías Estarás, Antonio González   +3 more
doaj   +1 more source

Arachidonic and linoleic acid derivatives impact oocyte ICSI fertilization--a prospective analysis of follicular fluid and a matched oocyte in a 'one follicle--one retrieved oocyte--one resulting embryo' investigational setting.

PLoS ONE, 2015
ObjectiveTo evaluate human oocyte ability to undergo fertilization and subsequent preimplantation embryonic development in relation to a wide panel of follicular fluid (FF) arachidonic acid derivatives (AAD) and linoleic acid derivatives (LAD) of ...
Przemysław Ciepiela, Tomasz Bączkowski, Arleta Drozd, Anna Kazienko, Ewa Stachowska, Rafał Kurzawa   +5 more
doaj   +1 more source