Increased Epoxyeicosatrienoic Acids and Hydroxyeicosatetraenoic Acids After Treatment of Iodide Intake Adjustment and 1,25-Dihydroxy-Vitamin D3 Supplementation in High Iodide Intake–Induced Hypothyroid Offspring Rats [PDF]
Frontiers in Physiology, 2021 Aim: This study aimed to investigate the potential role of fatty acids in high iodide intake–induced hypothyroidism and its complications and also in the intervention of iodide intake adjustment and 1,25-dihydroxy-vitamin D3 [1,25(OH)2D3] supplementation.
Qing Liu +3 more
doaj +2 more sources
Arachidonic acid-derived hydroxyeicosatetraenoic acids are positively associated with colon polyps in adult males: a cross-sectional study [PDF]
Scientific Reports, 2019 Oxylipids are potent lipid mediators associated with inflammation-induced colon carcinomas and colon tumor survival. Therefore, oxylipid profiles may be useful as novel biomarkers of colon polyp presence.
C. Austin Pickens +3 more
doaj +2 more sources
Journal of Lipid Research, 1999 12-Lipoxygenase and cyclooxygenase 1 are the dominating enzymes that metabolize arachidonic acid in human platelets. In addition to the conversion of arachidonic acid to 12(S)-hydroxyeicosatetraenoic acid, 12-lipoxygenase can also utilize 5(S ...
Marina Dadaian, Par Westlund
doaj +3 more sources
Renal And Cardiovascular Actions Of 20-Hydroxyeicosatetraenoic Acid And Epoxyeicosatrienoic Acids [PDF]
Clinical and Experimental Pharmacology and Physiology, 2000 SUMMARY1. Arachidonic acid (AA) is metabolized by cytochrome P450 (CYP)‐dependent pathways to epoxyeicosatrienoic acids (EET) and 20‐hydroxyeicosatetraenoic acid (20‐HETE) in the kidney and the peripheral vasculature.2. The present short review summarizes the renal and cardiovascular actions of these important mediators.3. Epoxyeicosatrienoic acids are
, M Alonso-Galicia, D R Harder
exaly +3 more sources
Association Between Complete Blood Count and the Lipoxygenase Pathway in Hashimoto’s Thyroiditis [PDF]
CellsBackground: Hashimoto’s Thyroiditis (HT) is one of the most common autoimmune diseases worldwide, yet little is known about the role of lipid mediators in its pathogenesis. This study investigated whether there is a link between complete blood count (CBC)
Karolina Wrońska +3 more
doaj +2 more sources
Incorporation of Hydroxyeicosatetraenoic Acid Isomers into Macrophage Phospholipids Reveals Class-Specific Distribution [PDF]
BiomoleculesPhospholipid fatty acid incorporation and remodeling are central processes through which immune cells adapt their membranes during activation. Macrophages are known to integrate oxidized fatty acids into phospholipids, yet the principles governing this ...
Alvaro Garrido +4 more
doaj +2 more sources
Mitochondrial metabolism of 12- and 15-hydroxyeicosatetraenoic acids.
Journal of Lipid Research, 1994 We have previously demonstrated that peroxisomal-deficient human skin fibroblasts and mutant Chinese hamster ovary cells do not convert 12- and 15-hydroxyeicosatetraenoic acids (HETEs) to chain-shortened, polar metabolites, suggesting that peroxisomes ...
J.A. Gordon +3 more
doaj +3 more sources
Orphan Cytochromes P450 as Possible Pharmacological Targets or Biomarkers in Breast Cancer [PDF]
Current Issues in Molecular BiologyAlthough significant advances in the treatment of breast cancer have been made over the last few decades, searching for more effective prophylaxis and therapy for this type of cancer is still topical.
Barbara Licznerska +2 more
doaj +2 more sources
Changes in erythrocyte membrane epoxyeicosatrienoic, dihydroxyeicosatrienoic, and hydroxyeicosatetraenoic acids during pregnancy [PDF]
Life Sciences, 2021 Emily Fay, Mary Hebert, Rheem Totah
exaly +2 more sources
Non-Targeted Metabolomic Characterization of Metabolites during the Fermentation of ‘Golden Flower’ Eucommia ulmoides Leaf Tea [PDF]
Shipin Kexue, 2023 In order to investigate the changes of metabolite profile during the fermentation of ‘Golden Flower’ Eucommia ulmoides leaf tea, quantitative, qualitative and differential analyses of small molecule metabolites in tea samples at different fermentation ...
YAN Fei, QU Dong, JI Pengbin, LI Xinsheng, XI Linjie
doaj +1 more source