Results 11 to 20 of about 402 (97)

Stimulation of Phospholipase A2 by Toxic Main Group Heavy Metals: Partly Dependent on G‐proteins?

Metal-Based Drugs, Volume 2, Issue 2, Page 91-98, 1995., 1994
Organometals induce platelet aggregation and inorganic metal ions such as Cd2+ or Pb2+ sensitise human blood platelets to aggregating agents and this action is associated with the liberation of arachidonic acid and eicosanoid formation. The same mechanism is observed using human leukaemia cells (HL‐60) when treated with MeHgCl or Et3PbCl .
H. F. Krug
wiley   +1 more source

12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE) does not stimulate proliferation of human neonatal keratinocytes

Journal of Investigative Dermatology, 1989
We have developed an assay to study the effect of drugs on the proliferation of neonatal human skin-derived keratinocytes in vitro. Expanding populations of neonatal keratinocytes were cultured in low concentrations (0.5%) of fetal calf serum for up to 12 d.
Otto, William R., Barr, Robert M., Dowd, Pauline M., Wright, Nicholas A., Greaves, Malcolm W.   +4 more
openaire   +2 more sources

Cyclic GMP Metabolism in Psoriasis: Activation of Soluble Epidermal Guanylate Cyclase by Arachidonic Acid and 12-Hydroxy-5,8,10,14-Eicosatetraenoic Acid

Journal of Investigative Dermatology, 1980
Soluble guanylate cyclase activity was measured in normal and psoriatic human epidermis. The specific activity of guanylate cyclase was determined to be increased 10-fold and 3-fold in involved and uninvolved epidermis of psoriatics, respectively, compared to normal epidermis.
Cantieri, John S., Graff, Gustav, Goldberg, Nelson D.   +2 more
openaire   +2 more sources

Mechanism for the formation of dihydro metabolites of 12-hydroxyeicosanoids. Conversion of leukotriene B4 and 12-hydroxy-5,8,10,14-eicosatetraenoic acid to 12-oxo intermediates.

Journal of Biological Chemistry, 1991
Eicosanoids containing a 12-hydroxyl group preceded by at least two conjugated double bonds are metabolized to 10,11-dihydro and 10,11-dihydro-12-oxo products by porcine polymorphonuclear leukocytes (PMNL) (Wainwright, S. L., Falck, J. R., Yadagiri, P., and Powell, W. S. (1990) Biochemistry 29, 10126-10135). These 10,11-dihydro metabolites could either
S L, Wainwright, W S, Powell
openaire   +2 more sources

Circulating oxylipin and bile acid profiles of dexmedetomidine, propofol, sevoflurane, and S-ketamine: a randomised controlled trial using tandem mass spectrometry. [PDF]

BJA Open, 2022
Nummela A, Laaksonen L, Scheinin A, Kaisti K, Vahlberg T, Neuvonen M, Valli K, Revonsuo A, Perola M, Niemi M, Scheinin H, Laitio T.   +11 more
europepmc   +1 more source

Mechanism of macroalgae Gracilaria bailiniae responding to cadmium and lanthanum. [PDF]

Front Plant Sci, 2022
Huang B, Cui J, Ran Y, Chen C, Li F, Zhang Y, Li Z, Xie E.   +7 more
europepmc   +1 more source

INTERCEPT Pathogen Reduction in Platelet Concentrates, in Contrast to Gamma Irradiation, Induces the Formation of trans-Arachidonic Acids and Affects Eicosanoid Release during Storage. [PDF]

Biomolecules, 2022
Leitner GC, Hagn G, Niederstaetter L, Bileck A, Plessl-Walder K, Horvath M, Kolovratova V, Tanzmann A, Tolios A, Rabitsch W, Wohlfarth P, Gerner C.   +11 more
europepmc   +1 more source

Unraveling the Role of 12- and 20- HETE in Cardiac Pathophysiology: G-Protein-Coupled Receptors, Pharmacological Inhibitors, and Transgenic Approaches. [PDF]

J Cardiovasc Pharmacol, 2021
Pascale JV, Lucchesi PA, Garcia V.
europepmc   +1 more source

Spiro-Flavonoids in Nature: A Critical Review of Structural Diversity and Bioactivity. [PDF]

Molecules, 2023
Pecio Ł, Pecio S, Mroczek T, Oleszek W.
europepmc   +1 more source

A review of non-prostanoid, eicosanoid receptors: expression, characterization, regulation, and mechanism of action. [PDF]

J Cell Commun Signal, 2022
Biringer RG.
europepmc   +1 more source