Results 51 to 60 of about 10,969 (168)

Studies on porcine arachidonate 12-lipoxygenase using its monoclonal antibodies.

Journal of Biological Chemistry, 1986
Monoclonal antibodies were raised against arachidonate 12-lipoxygenase using a partially purified enzyme from porcine leukocytes as an antigen. Immunohistochemical studies indicated a selective localization of 12-lipoxygenase in the cytosol of polymorphonuclear leukocytes.
F, Shinjo, T, Yoshimoto, C, Yokoyama, S, Yamamoto, S, Izumi, N, Komatsu, K, Watanabe   +6 more
openaire   +2 more sources

Mechanism and role of regulated cell death in tumor immunity and immunotherapy

Cancer Communications, Volume 45, Issue 11, Page 1456-1495, November 2025.
Abstract Cancer immune checkpoint inhibitors (ICIs) have brought breakthroughs, but only about one‐third of cancer patients benefit from ICIs. In recent years, targeting non‐apoptotic regulated cell death (RCD) subtypes, such as ferroptosis, necroptosis, autophagy, cuproptosis, and pyroptosis, has emerged as a novel strategy in cancer therapy due to ...
Jingwen Hu, Yan Li, Bingjie Lian, Yitao Mao, Luqing Zhao   +4 more
wiley   +1 more source

In Vitro, In Vivo, and Clinical Trial Approaches to Investigate the Effects of Medicinal Plants on Burn Wound Healing: A Systematic Review

International Wound Journal, Volume 22, Issue 11, November 2025.
ABSTRACT Use of synthetic drugs for the treatment of burn wounds has decreased due to adverse effects, and they are gradually being replaced by compounds obtained from natural products, especially medicinal plants. This review focused on pre‐clinical and clinical studies examining the efficacy of medicinal plants in promoting burn wound healing.
Mahdi Bagheri, Seyed Mohammad Zarei, Mostafa Soodmand, Hossein Mardani Nafchi, Mir Hossein Hashemi Poor   +4 more
wiley   +1 more source

Carnosic acid enhances cisplatin sensitivity and suppresses gastric cancer progression via the TP53/SLC7A11/ALOX12 axis

Hereditas
Background Gastric cancer (GC) remains a significant global health challenge due to its high mortality and frequent resistance to chemotherapy drugs like cisplatin (DDP). Carnosic acid (CA), a phenolic diterpene, exhibits potential anti-cancer properties.
Li Zhou, Bin Xu, Baojian Li
doaj   +1 more source

Parent-determined oral montelukast therapy for preschool wheeze with stratification for arachidonate 5-lipoxygenase (ALOX5) promoter genotype: a multicentre, randomised, placebo-controlled trial

Efficacy and Mechanism Evaluation, 2015
Background: The clinical effectiveness of intermittent montelukast for wheeze in young children is unclear. Previous work has been equivocal. Variation in copy numbers of the specificity protein 1-binding motif in the arachidonate 5-lipoxygenase (ALOX5 ...
Chinedu Nwokoro, Hitesh Pandya, Stephen Turner, Sandra Eldridge, Christopher J Griffiths, Tom Vulliamy, David Price, Marek Sanak, John W Holloway, Rossa Brugha, Lee Koh, Iain Dickson, Clare Rutterford, Jonathan Grigg   +13 more
doaj   +1 more source

Targeting of the Alox12-12-HETE in Blast Crisis Chronic Myeloid Leukemia Inhibits Leukemia Stem/Progenitor Cell Function

Cancer Management and Research, 2020
Si Gao,1,2,* Jialin Hu,3,* Yong Li4 1Department of Haematology and Rheumatology, Wuhan Fourth Hospital, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China; 2The Central ...
Gao S, Hu J, Li Y
doaj  

Effect of pulsed electromagnetic field treatment on programmed resolution of inflammation pathway markers in human cells in culture

Journal of Inflammation Research, 2015
Nicole J Kubat,1 John Moffett,2 Linley M Fray2 1Nicole Kubat Consulting, Pasadena, CA, USA; 2Life Science Department, Regenesis Biomedical, Inc., Scottsdale, AZ, USA Abstract: Inflammation is a complex process involving distinct but overlapping ...
Kubat NJ, Moffett J, Fray LM
doaj  

Integration of hepatic lipidomics and transcriptomics reveals dysregulation of lipid metabolism in a golden hamster model of visceral leishmaniasis

Frontiers in Immunology
Visceral leishmaniasis (VL), the most severe form of leishmaniasis, remains a significant public health concern that cannot be overlooked in underdeveloped regions.
Dongmei Yuan, Hanxiao Qin, Zeying Yu
doaj   +1 more source

Luteolin attenuates CCl4-induced hepatic injury by inhibiting ferroptosis via SLC7A11

BMC Complementary Medicine and Therapies
Background Luteolin (3,4,5,7-tetrahydroxy flavone) is reported to strongly protect from acute carbon tetrachloride (CCl4) -induced liver injury or fibrosis. Ferroptosis can be induced by hepatic injury, and contributes to liver fibrosis development.
Zhiqiang Han, Batudeligen, Hongmei Chen, Narisu, Anda, Yanhua Xu, Lan Xue   +6 more
doaj   +1 more source

Molecular structure and function of the porcine arachidonate 12-lipoxygenase gene.

Journal of Biological Chemistry, 1992
The gene encoding arachidonate 12-lipoxygenase was cloned from a porcine EMBL3 genomic library using a cDNA probe of the enzyme, and its nucleotide sequence was determined. The gene consists of 14 exons with 13 introns, and spans approximately 8 kilobases.
T, Arakawa, T, Oshima, K, Kishimoto, T, Yoshimoto, S, Yamamoto   +4 more
openaire   +2 more sources