Results 141 to 150 of about 5,194 (173)
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Biochemical and Biophysical Research Communications, 1986
Cirsiliol and AA861, specific arachidonate 5-lipoxygenase inhibitors, showed potent antiproliferative effects on human leukemic cell lines K562, Molt4B and HL60. On the other hand, HeLa cells were not affected by these drugs. In the inhibitor treated and growth retarded leukemia cells, the rates of synthesis of DNA, RNA and protein were markedly ...
T, Tsukada, K, Nakashima, S, Shirakawa
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Cirsiliol and AA861, specific arachidonate 5-lipoxygenase inhibitors, showed potent antiproliferative effects on human leukemic cell lines K562, Molt4B and HL60. On the other hand, HeLa cells were not affected by these drugs. In the inhibitor treated and growth retarded leukemia cells, the rates of synthesis of DNA, RNA and protein were markedly ...
T, Tsukada, K, Nakashima, S, Shirakawa
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Cerebral Edema Induced by Arachidonic Acid: Role of Leukocytes and 5-Lipoxygenase Products
Neurosurgery, 1989Arachidonic acid is released from cellular phospholipid membranes after brain injury associated with vasogenic edema. Intracerebral injection of arachidonic acid results in rapid breakdown of the blood-brain barrier, followed by an increase in brain water and sodium content.
S M, Papadopoulos, K L, Black, J T, Hoff
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Lipoxin Syntheses by Arachidonate 12- and 5-Lipoxygenases Purified from Porcine Leukocytes
1988Recently, we were successful in the purification of 12-lipoxygenase1 and 5-lipoxygenase2 from porcine leukocytes by immunoaffinity chromatography using their monoclonal antibodies which were raised with the crude enzyme preparations as antigen3, 4. In this chapter the lipoxin biosynthesis will be discussed as catalytic properties of these purified ...
S, Yamamoto +6 more
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Neutrophil Producing Capacity of 5-Lipoxygenase Metabolites of Arachidonic Acid After Major Surgery
1989It is well known that patients who undergo surgical operations have a high risk of infection and sepsis. One explanation for this high risk may be a depression of neutrophil functions at the postoperative period. In the present study, the effects of surgical stresses on neutrophil functions were studied in ten patients who underwent general anesthesia ...
J, Utoh +5 more
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[34] Leukocyte arachidonate 5-lipoxygenase: Isolation and characterization
1990Carol A. Rouzer, Bengt Samuelsson
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Arachidonate 15-lipoxygenase type B: Regulation, function, and its role in pathophysiology
Frontiers in Pharmacology, 2022exaly