Results 1 to 10 of about 364 (115)

Avenanthramides as lipoxygenase inhibitors [PDF]

Heliyon, 2020
Avenanthramides (AVAs) present in oats are amides of anthranilic and cinnamic acids. AVAs are potent antioxidants and have anti-inflammatory properties.
Rikard Landberg, Kerstin Sunnerheim, Lena H. Dimberg   +2 more
doaj   +5 more sources

The Inhibition of 15-Lipoxygenase by Blechnum orientale Leaves and its Glycoside-flavonoid Isolates: In Vitro and In Silico Studies

Hayati Journal of Biosciences, 2022
Fern is one of the groups of primitive plants rich in secondary metabolites that are commonly used to treat various diseases, including antioxidant, anti-hyaluronidase, anti-inflammation, and respiratory disease but less investigated.
Rissyelly Rissyelly, Syaikhul Aziz, Frangky Sangande, Agung Wibawa Mahatva Yodha, Krisyanti Budipramana, Elfahmi Elfahmi, Sukrasno Sukrasno   +6 more
doaj   +1 more source

Bioactive Peptides and Protein Hydrolysates as Lipoxygenase Inhibitors

Biology, 2023
Lipoxygenases are non-heme iron-containing enzymes that catalyze the oxidation of polyunsaturated fatty acids, resulting in the production of lipid hydroperoxides, which are precursors of inflammatory lipid mediators. These enzymes are widely distributed
Fai-Chu Wong, Tsun-Thai Chai
doaj   +1 more source

5-Lipoxygenase inhibitors attenuate TNF-α-induced inflammation in human synovial fibroblasts. [PDF]

PLoS ONE, 2014
The lipoxygenase isoform of 5-lipoxygenase (5-LOX) is reported to be overexpressed in human rheumatoid arthritis synovial tissue and involved in the progress of inflammatory arthritis.
Han-Ching Lin, Tzu-Hung Lin, Ming-Yueh Wu, Yung-Cheng Chiu, Chih-Hsin Tang, Mann-Jen Hour, Houng-Chi Liou, Huang-Ju Tu, Rong-Sen Yang, Wen-Mei Fu   +9 more
doaj   +1 more source

Different Structures—Similar Effect: Do Substituted 5-(4-Methoxyphenyl)-1H-indoles and 5-(4-Methoxyphenyl)-1H-imidazoles Represent a Common Pharmacophore for Substrate Selective Inhibition of Linoleate Oxygenase Activity of ALOX15?

Molecules, 2023
Mammalian 15-lipoxygenases (ALOX15) are lipid peroxidizing enzymes that exhibit variable functionality in different cancer and inflammation models. The pathophysiological role of linoleic acid- and arachidonic acid-derived ALOX15 metabolites rendered ...
Alexander Zhuravlev, Alejandro Cruz, Vladislav Aksenov, Alexey Golovanov, José M. Lluch, Hartmut Kuhn, Àngels González-Lafont, Igor Ivanov   +7 more
doaj   +1 more source

A review on the relationship between Arachidonic acid 15-Lipoxygenase (ALOX15) and diabetes mellitus [PDF]

PeerJ, 2023
Arachidonic acid 15-lipoxygenase (ALOX15), as one of the lipoxygenase family, is mainly responsible for catalyzing the oxidation of various fatty acids to produce a variety of lipid components, contributing to the pathophysiological processes of various ...
Kaiying He, Xiaochun Zhou, Hongxuan Du, Jing Zhao, Rongrong Deng, Jianqin Wang   +5 more
doaj   +2 more sources

Design and synthesis of new esters of terpenoid alcohols as 15-lipoxygenase inhibitors [PDF]

Iranian Journal of Basic Medical Sciences, 2018
Objective(s): 15-Lipoxygenases are one of the iron-containing proteins capable of performing peroxidation of unsaturated fatty acids in animals and plants. The critical role of enzymes in the formation of inflammations, sensitivities, and some cancers has
Hamid Sadeghian, Seyed Mohammad Seyedi, Zeinab Jafari   +2 more
doaj   +1 more source

Biosynthesis of the Novel Endogenous 15-Lipoxygenase Metabolites N-13-Hydroxy-octodecadienoyl-ethanolamine and 13-Hydroxy-octodecadienoyl-glycerol by Human Neutrophils and Eosinophils

Cells, 2021
The endocannabinoids 2-arachidonoyl-glycerol and N-arachidonoyl-ethanolamine are lipids regulating many physiological processes, notably inflammation. Endocannabinoid hydrolysis inhibitors are now being investigated as potential anti-inflammatory agents.
Anne-Sophie Archambault, Francesco Tinto, Élizabeth Dumais, Volatiana Rakotoarivelo, Magdalena Kostrzewa, Pier-Luc Plante, Cyril Martin, Mélissa Simard, Cristoforo Silvestri, Roxane Pouliot, Michel Laviolette, Louis-Philippe Boulet, Rosa Maria Vitale, Alessia Ligresti, Vincenzo Di Marzo, Nicolas Flamand   +15 more
doaj   +1 more source

α-Conotoxins and α-Cobratoxin Promote, while Lipoxygenase and Cyclooxygenase Inhibitors Suppress the Proliferation of Glioma C6 Cells

Marine Drugs, 2021
Among the brain tumors, glioma is the most common. In general, different biochemical mechanisms, involving nicotinic acetylcholine receptors (nAChRs) and the arachidonic acid cascade are involved in oncogenesis.
Tatiana I. Terpinskaya, Alexey V. Osipov, Elena V. Kryukova, Denis S. Kudryavtsev, Nina V. Kopylova, Tatsiana L. Yanchanka, Alena F. Palukoshka, Elena A. Gondarenko, Maxim N. Zhmak, Victor I. Tsetlin, Yuri N. Utkin   +10 more
doaj   +1 more source

Blockade of TRPM7 channel activity and cell death by inhibitors of 5-lipoxygenase.

PLoS ONE, 2010
TRPM7 is a ubiquitous divalent-selective ion channel with its own kinase domain. Recent studies have shown that suppression of TRPM7 protein expression by RNA interference increases resistance to ischemia-induced neuronal cell death in vivo and in vitro,
Hsiang-Chin Chen, Jia Xie, Zheng Zhang, Li-Ting Su, Lixia Yue, Loren W Runnels   +5 more
doaj   +1 more source