Avenanthramides as lipoxygenase inhibitors [PDF]
Heliyon, 2020 Avenanthramides (AVAs) present in oats are amides of anthranilic and cinnamic acids. AVAs are potent antioxidants and have anti-inflammatory properties.
Rikard Landberg +2 more
doaj +12 more sources
Bioactive Peptides and Protein Hydrolysates as Lipoxygenase Inhibitors [PDF]
Biology, 2023 Lipoxygenases are non-heme iron-containing enzymes that catalyze the oxidation of polyunsaturated fatty acids, resulting in the production of lipid hydroperoxides, which are precursors of inflammatory lipid mediators. These enzymes are widely distributed
Fai-Chu Wong, Tsun-Thai Chai
doaj +4 more sources
5-Lipoxygenase inhibitors attenuate TNF-α-induced inflammation in human synovial fibroblasts. [PDF]
PLoS ONE, 2014 The lipoxygenase isoform of 5-lipoxygenase (5-LOX) is reported to be overexpressed in human rheumatoid arthritis synovial tissue and involved in the progress of inflammatory arthritis.
Han-Ching Lin +9 more
doaj +8 more sources
Design and synthesis of new esters of terpenoid alcohols as 15-lipoxygenase inhibitors [PDF]
Iranian Journal of Basic Medical Sciences, 2018 Objective(s): 15-Lipoxygenases are one of the iron-containing proteins capable of performing peroxidation of unsaturated fatty acids in animals and plants. The critical role of enzymes in the formation of inflammations, sensitivities, and some cancers has
Hamid Sadeghian +2 more
doaj +2 more sources
Blockade of TRPM7 channel activity and cell death by inhibitors of 5-lipoxygenase. [PDF]
PLoS ONE, 2010 TRPM7 is a ubiquitous divalent-selective ion channel with its own kinase domain. Recent studies have shown that suppression of TRPM7 protein expression by RNA interference increases resistance to ischemia-induced neuronal cell death in vivo and in vitro,
Hsiang-Chin Chen +5 more
doaj +2 more sources
α-Conotoxins Enhance both the In Vivo Suppression of Ehrlich carcinoma Growth and In Vitro Reduction in Cell Viability Elicited by Cyclooxygenase and Lipoxygenase Inhibitors [PDF]
Marine Drugs, 2020 Several biochemical mechanisms, including the arachidonic acid cascade and activation of nicotinic acetylcholine receptors (nAChRs), are involved in increased tumor survival. Combined application of inhibitors acting on these two pathways may result in a
Alexey V. Osipov +6 more
doaj +2 more sources
Substrate specificity effects of lipoxygenase products and inhibitors on soybean lipoxygenase-1 [PDF]
Bioorganic & Medicinal Chemistry, 2009 Recently, it has been shown that lipoxygenase (LO) products affect the substrate specificity of human 15-LO. In the current paper, we demonstrate that soybean LO-1 (sLO-1) is not affected by its own products, however, inhibitors which bind the allosteric site, oleyl sulfate (OS) and palmitoleyl sulfate (PS), not only lower catalytic activity, but also ...
Wecksler, Aaron T +2 more
openaire +7 more sources
Novel lipoxygenase inhibitors as neuroprotective reagents [PDF]
Journal of Neuroscience Research, 2007 AbstractThe lipid‐metabolizing enzyme 12/15‐lipoxygenase (12/15‐LOX) mediates cell death resulting from oxidative stress in both neurons and oligodendrocytes. Specifically, it may contribute to the pathophysiology of stroke and Alzheimer's and Parkinson's diseases.
van Leyen, Klaus +7 more
openaire +7 more sources
Microwave Assisted Synthesis of Antioxidant Dihydro-Pyrazole Hybrids as Possible Lipoxygenase Inhibitors [PDF]
MoleculesFree radicals and inflammation have pivotal role in various degenerative diseases like cancer, rheumatoid arthritis, diabetes, cardiovascular and neurodegenerative disorders.
Stergiani-Chrysovalanti Peitzika +2 more
doaj +2 more sources
A fluorescence-based assay for measuring the redox potential of 5-lipoxygenase inhibitors. [PDF]
PLoS ONE, 2014 The activities and side effects of 5-lipoxygenase (5-LO) inhibitors can be predicted by identifying their redox mechanisms. In this study, we developed a fluorescence-based method to measure the redox potential of 5-LO inhibitors and compared it to the ...
Sangchul Lee +3 more
doaj +2 more sources