Results 21 to 30 of about 25,002 (268)

A new treatment for severe pulmonary arterial hypertension based on an old idea: inhibition of 5-lipoxygenase

Pulmonary Circulation, 2020
It has been generally accepted that severe forms of pulmonary arterial hypertension are associated with inflammation. Plasma levels in patients with severe pulmonary arterial hypertension show elevated levels of interleukins and mediators of inflammation
Norbert F. Voelkel, Marc Peters-Golden
doaj   +1 more source

Substituted pyrrolo[1,2-a][1,2,4]triazolo-(triazino-)[c]quinazolines - a promising class of lipoxygenase inhibitors

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2020
The modern strategy of potential biologically active molecules search (“drug-design”) is based on several innovation approaches. The method of high thrоughрut biological screening and method of molecular modeling deserves the most attention among such ...
V. V. Stavytskyi, I. S. Nosulenko, O. O. Portna, V. M. Shvets, O. Yu. Voskoboynik, S. І. Kоvalenko   +5 more
doaj   +1 more source

Inhibition of tumour growth by lipoxygenase inhibitors [PDF]

British Journal of Cancer, 1996
The potential involvement of lipoxygenase metabolites in the tumour growth stimulatory activity of arachidonic and linoleic acid has been studied using the 5-lipoxygenase inhibitors, BWA4C, BWB70C and Zileuton. In vitro the former two agents were relatively potent inhibitors of growth of murine adenocarcinomas (MACs) with IC50 values < 10 microM ...
H J, Hussey, M J, Tisdale
openaire   +2 more sources

Inhibition of lipoxygenase affects induction of both direct and indirect plant defences against herbivorous insects [PDF]

, 2009
Herbivore-induced plant defences influence the behaviour of insects associated with the plant. For biting–chewing herbivores the octadecanoid signal-transduction pathway has been suggested to play a key role in induced plant defence.
Marcel Dicke, Dicke, M., Martin J. Müller, Posthumus, M.A., Broekhoven, S., Maarten A. Posthumus, Joop J. A. van Loon, Bruinsma, M., Müller, M.J., Loon, J.J.A., van, van Loon, J.J.A., Maaike Bruinsma, Erik H. Poelman, Poelman, E.H., Sarah van Broekhoven   +14 more
core   +1 more source

Non-redox Lipoxygenase Inhibitors from

Natural Product Communications, 2018
Eight alkaloids recently isolated from the roots of Nauclea orientalis (L.) L. were obtained to evaluate the lipoxygenase (LOX) inhibitory activity. According to the LOX inhibitory assay, the cis isomer 1 (IC 50 39.2±1.1 μM) was more potent than the ...
Serm Surapinit, Jirapast Sichaem, Santi Tip-pyang   +2 more
doaj   +1 more source

Role of Certain Elicitors on the Chemical Induction of Resistance in Tomato against the Leaf Caterpillar Spodoptera litura Fab.

Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 2008
Mill. The four presumptive defenses manipulated were protinase inhibitors, polyphenol oxidase, peroxidase and lipoxygenase. The elicitors used were jasmonic acid (JA), salicylic acid (SA) and PGPR Pseudomonas aeruginosa.
M. MELVIN JOE, N. MUTHUKUMARAN
doaj   +1 more source

Plasmin Inhibitors Prevent Leukocyte Accumulation and Remodeling Events in the Postischemic Microvasculature [PDF]

, 2011
Clinical trials revealed beneficial effects of the broad-spectrum serine protease inhibitor aprotinin on the prevention of ischemia-reperfusion (I/R) injury. The underlying mechanisms remained largely unclear.
Nina Berberich, Rehberg, Markus, Wymann, Matthias P., Wymann, M. P., Uhl, B., Lerchenberger, Max, Uhl, Bernd, Berberich, Nina, Reichel, Christoph A., Bernd Uhl, Markus Rehberg, Matthias P. Wymann, Zahler, Stefan, Reichel, C. A., Uhl Bernd, Berberich Nina, Krombach Fritz, Lerchenberger, M., Stefan Zahler, Reichel Christoph A., Berberich, N., Fritz Krombach, Rehberg Markus, Zahler, S., Christoph A. Reichel, Krombach, Fritz, Max Lerchenberger, Krombach, F., Lerchenberger Max, Zahler Stefan, Matthias P Wymann, Rehberg, M., Christoph A Reichel, Wymann Matthias P.   +33 more
core   +1 more source

A voltammetric assay of antioxidants and inhibitors of soybean lipoxygenase [PDF]

, 2003
Antioxidant activity and/or the inhibition of lipoxygenases may contribute to the cell and tissue protective properties of flavonoids. Soybean lipoxygenase-1 (LOX-1), is a useful paradigm for lipoxygenases isolated from different sources, and can be used
Pérusse, Pascal, Leech, Dónal
core   +1 more source

Fucophlorethol C, a phlorotannin as a lipoxygenase inhibitor [PDF]

Bioscience, Biotechnology, and Biochemistry, 2015
Abstract Fucophlorethol C, a phlorotannin, was isolated from the brown alga Colpomenia bullosa (Scyto-siphonaceae) as a novel lipoxygenase (LOX) inhibitor. It was obtained as a free form from natural origin for the first time. The compound inhibited a soybean LOX to the same extent as the known inhibitor nordihydroguaiaretic acid.
Kurihara, Hideyuki, Konno, Remi, Takahashi, Koretaro   +2 more
openaire   +3 more sources

Protective role of resolvin D1, a pro-resolving lipid mediator, in nonsteroidal anti-inflammatory drug-induced small intestinal damage.

PLoS ONE, 2021
Resolvin D1, a specialized pro-resolving lipid mediator produced from docosahexaenoic acid by 15- and 5-lipoxygenase, exerts anti-inflammatory effects driving to the resolution of inflammation.
Takuya Kuzumoto, Tetsuya Tanigawa, Akira Higashimori, Hiroyuki Kitamura, Yuji Nadatani, Koji Otani, Shusei Fukunaga, Shuhei Hosomi, Fumio Tanaka, Noriko Kamata, Yasuaki Nagami, Koichi Taira, Toshio Watanabe, Yasuhiro Fujiwara   +13 more
doaj   +1 more source