Results 21 to 30 of about 44,003 (300)
Blockade of TRPM7 channel activity and cell death by inhibitors of 5-lipoxygenase.
PLoS ONE, 2010 TRPM7 is a ubiquitous divalent-selective ion channel with its own kinase domain. Recent studies have shown that suppression of TRPM7 protein expression by RNA interference increases resistance to ischemia-induced neuronal cell death in vivo and in vitro,
Hsiang-Chin Chen +5 more
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Arzanol, a prenylated heterodimeric phloroglucinyl pyrone, inhibits eicosanoid biosynthesis and exhibits anti-inflammatory efficacy in vivo. [PDF]
, 2011 Based on its capacity to inhibit in vitro HIV-1 replication in T cells and the release of pro-inflammatory cytokines in monocytes, the prenylated heterodimeric phloroglucinyl α-pyrone arzanol was identified as the major anti-inflammatory and anti-viral ...
Appendino G +8 more
core +1 more source
Novel lipoxygenase inhibitors as neuroprotective reagents [PDF]
Journal of Neuroscience Research, 2007 AbstractThe lipid‐metabolizing enzyme 12/15‐lipoxygenase (12/15‐LOX) mediates cell death resulting from oxidative stress in both neurons and oligodendrocytes. Specifically, it may contribute to the pathophysiology of stroke and Alzheimer's and Parkinson's diseases.
van Leyen, Klaus +7 more
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Pulmonary Circulation, 2020 It has been generally accepted that severe forms of pulmonary arterial hypertension are associated with inflammation. Plasma levels in patients with severe pulmonary arterial hypertension show elevated levels of interleukins and mediators of inflammation
Norbert F. Voelkel, Marc Peters-Golden
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Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2020 The modern strategy of potential biologically active molecules search (“drug-design”) is based on several innovation approaches. The method of high thrоughрut biological screening and method of molecular modeling deserves the most attention among such ...
V. V. Stavytskyi +5 more
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Inhibition of tumour growth by lipoxygenase inhibitors [PDF]
British Journal of Cancer, 1996 The potential involvement of lipoxygenase metabolites in the tumour growth stimulatory activity of arachidonic and linoleic acid has been studied using the 5-lipoxygenase inhibitors, BWA4C, BWB70C and Zileuton. In vitro the former two agents were relatively potent inhibitors of growth of murine adenocarcinomas (MACs) with IC50 values < 10 microM ...
H J, Hussey, M J, Tisdale
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Non-redox Lipoxygenase Inhibitors from
Natural Product Communications, 2018 Eight alkaloids recently isolated from the roots of Nauclea orientalis (L.) L. were obtained to evaluate the lipoxygenase (LOX) inhibitory activity. According to the LOX inhibitory assay, the cis isomer 1 (IC 50 39.2±1.1 μM) was more potent than the ...
Serm Surapinit +2 more
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Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 2008 Mill. The four presumptive defenses manipulated were protinase inhibitors, polyphenol oxidase, peroxidase and lipoxygenase. The elicitors used were jasmonic acid (JA), salicylic acid (SA) and PGPR Pseudomonas aeruginosa.
M. MELVIN JOE, N. MUTHUKUMARAN
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PLoS ONE, 2021 Resolvin D1, a specialized pro-resolving lipid mediator produced from docosahexaenoic acid by 15- and 5-lipoxygenase, exerts anti-inflammatory effects driving to the resolution of inflammation.
Takuya Kuzumoto +13 more
doaj +1 more source
Fucophlorethol C, a phlorotannin as a lipoxygenase inhibitor [PDF]
Bioscience, Biotechnology, and Biochemistry, 2015 Abstract Fucophlorethol C, a phlorotannin, was isolated from the brown alga Colpomenia bullosa (Scyto-siphonaceae) as a novel lipoxygenase (LOX) inhibitor. It was obtained as a free form from natural origin for the first time. The compound inhibited a soybean LOX to the same extent as the known inhibitor nordihydroguaiaretic acid.
Kurihara, Hideyuki +2 more
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