Results 31 to 40 of about 23,162 (241)

Mitochondria‐Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave, Ashish B. Jadhav, Nitin B. Waghamode, Shubham Khot, Rajiya Khan, Ravi Hole, Shankar M. Dhobale, Manoj Aswar, Keshav Raj Paudel   +8 more
wiley   +1 more source

Antioxidant and lipoxygenase inhibition studies of 4-(3-bromophenyl)-[2,2'-bipyridine]-6-carboxylic acid and its metal complexes

Pakistan Journal of Pharmaceutical Sciences
Background: Synthesis of novel enzyme inhibitors and antioxidants is active research in pharmaceuticals sciences. Novel compounds with potential therapeutic value can be synthesized to help the body combat oxidative-stress related diseases.
Muneeb Yousuf, Agha Arslan Wasim, Mehreen Latif, Mohsin Ali, Saba Fazal-ur-Rehman   +4 more
doaj   +1 more source

Multitarget Molecular Hybrids of Cinnamic Acids

Molecules, 2014
In an attempt to synthesize potential new multitarget agents, 11 novel hybrids incorporating cinnamic acids and paracetamol, 4-/7-hydroxycoumarin, benzocaine, p-aminophenol and m-aminophenol were synthesized.
Aikaterini Peperidou, Dorothea Kapoukranidou, Christos Kontogiorgis, Dimitra Hadjipavlou-Litina   +3 more
doaj   +1 more source

Inhibitors of Human 5-Lipoxygenase Potently Interfere With Prostaglandin Transport

Frontiers in Pharmacology, 2022
5-Lipoxygenase (5-LO) is the key enzyme in the formation of pro-inflammatory leukotrienes (LT) which play an important role in a number of inflammatory diseases.
Astrid S. Kahnt, Carlo Angioni, Tamara Göbel, Bettina Hofmann, Jessica Roos, Jessica Roos, Svenja D. Steinbrink, Florian Rörsch, Dominique Thomas, Gerd Geisslinger, Kai Zacharowski, Sabine Grösch, Dieter Steinhilber, Thorsten J. Maier, Thorsten J. Maier   +14 more
doaj   +1 more source

Multi‐Omics Profiling of High‐Grade Serous Ovarian Cancer Reveals an Inflammation‐Related Lipid Metabolism Subtype Associated With Platinum Resistance

Advanced Science, EarlyView.
Through integrated proteomic and metabolomic profiling, Zhao et al. identified three molecular subtypes of high‐grade serous ovarian cancer. The high‐risk subtype exhibits activated arachidonic acid metabolism and cyclooxygenase‐2 overexpression. This metabolic axis promotes M2‐like macrophage infiltration, which contributes to platinum resistance ...
Yuxi Zhao, Junyi Li, Bo Zheng, Wanshan Liu, Yaru Wang, Shufeng Wang, Ying Cui, Huiqin Guo, Hongxia Wang, Ting Xiao, Kun Qian, Jing Zuo   +11 more
wiley   +1 more source

The Impact of Helicobacter pylori Urease upon Platelets and Consequent Contributions to Inflammation

Frontiers in Microbiology, 2017
Gastric infection by Helicobacter pylori is considered a risk factor for gastric and duodenal cancer, and extragastric diseases. Previous data have shown that, in a non-enzymatic way, H.
Adriele Scopel-Guerra, Deiber Olivera-Severo, Deiber Olivera-Severo, Fernanda Staniscuaski, Fernanda Staniscuaski, Augusto F. Uberti, Augusto F. Uberti, Natália Callai-Silva, Natália Jaeger, Bárbara N. Porto, Celia R. Carlini   +10 more
doaj   +1 more source

Docking Studies and Molecular Dynamics Simulation of Compounds Contained in Kaempferia Galanga L. to Lipoxygenase (LOX) for Anti-Inflammatory Drugs

Journal of Mathematical and Fundamental Sciences, 2021
Inflammation is a self-protective response to start the healing process. An anti-inflammatory target worth developing are lipoxygenase inhibitors, which have been studied for several diseases, including severe respiratory disease.
Supandi Supandi, Yeni Yeni, Lusi Putri Dwita   +2 more
doaj   +1 more source

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Advanced Science, EarlyView.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl, David Holubek, Klaus Speck, Raphael Wildermuth, Franz‐Lucas Haut, Stephan Permann, Immanuel Plangger, Christian Steinborn, Zhigang Rao, Danilo D'Avino, Ida Cerqua, Julia Stadler, Fiorentina Roviezzo, Peter Schlenke, Anita Siller, Harald Schennach, Solveigh C. Koeberle, Eva‐Maria Pferschy‐Wenzig, Antonietta Rossi, Thomas Magauer, Andreas Koeberle   +20 more
wiley   +1 more source

Small Multitarget Molecules Incorporating the Enone Moiety

Molecules, 2019
Chalcones represent a class of small drug/druglike molecules with different and multitarget biological activities. Small multi-target drugs have attracted considerable interest in the last decade due their advantages in the treatment of complex and ...
Thalia Liargkova, Nikolaos Eleftheriadis, Frank Dekker, Efstathia Voulgari, Constantinos Avgoustakis, Marina Sagnou, Barbara Mavroidi, Maria Pelecanou, Dimitra Hadjipavlou-Litina   +8 more
doaj   +1 more source

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

Advanced Science, EarlyView.
In macrophages, senkyunolide I (SEI) directly targets the K12 residue of VDAC1 to inhibit its stress‐induced oligomerization, a critical upstream event that effectively prevents mitochondrial DNA release and subsequent cGAS‐STING pathway activation.
Zhiming Ye, Yihang Huang, Bohao Han, Lei Zhang, Can Yu, Yang Yang, Bing Liu, Yongping Jian, Zhixiang Xu, Cheng Zeng   +9 more
wiley   +1 more source