Results 1 to 10 of about 34,376 (260)
Multitarget Drugs: an Epigenetic Epiphany [PDF]
ChemMedChem, 2016 AbstractEpigenetics refers to changes in a biological phenotype that are not due to an underlying change in genotype. In eukaryotes, epigenetics involves a set of chemical modifications of the DNA and the histone proteins in nucleosomes. These dynamic changes are carried out by enzymes and modulate protein–protein and protein–nucleic acid interactions ...
A Ganesan
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A Definition of “Multitargeticity”: Identifying Potential Multitarget and Selective Ligands Through a Vector Analysis [PDF]
Frontiers in Chemistry, 2020 The design of multitarget drugs is an essential area of research in Medicinal Chemistry since they have been proposed as potential therapeutics for the management of complex diseases. However, defining a multitarget drug is not an easy task. In this work, we propose a vector analysis for measuring and defining "multitargeticity." We developed terms ...
Juan Rodrigo Salazar +1 more
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“Statistics 103” for Multitarget Tracking [PDF]
Sensors, 2019 The finite-set statistics (FISST) foundational approach to multitarget tracking and information fusion was introduced in the mid-1990s and extended in 2001. FISST was devised to be as “engineering-friendly” as possible by avoiding avoidable mathematical abstraction and complexity—and, especially, by avoiding measure theory and measure-theoretic point ...
Ronald Mahler
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Hippocampal Avoidance in Multitarget Radiosurgery [PDF]
Cureus, 2021 Brain metastases are a common complication for patients diagnosed with cancer. As stereotactic radiosurgery (SRS) becomes a more prevalent treatment option for patients with many brain metastases, further research is required to better characterize the ability of SRS to treat large numbers of metastases (≥4) and the impact on normal brain tissue and ...
Gude, Zachary +3 more
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Frontiers in Pharmacology, 2021 Myocardial ischemia (MI) is one of the most common cardiovascular diseases with high incidence and mortality. Huang-Lian-Jie-Du-Tang (HLJDT) is a classic traditional Chinese prescription to clear “heat” and “poison”.
Li Li +8 more
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Molecules, 2023 Despite the significant outcomes attained by scientific research, breast cancer (BC) still represents the second leading cause of death in women. Estrogen receptor-positive (ER+) BC accounts for the majority of diagnosed BCs, highlighting the disruption ...
Silvia Gobbi +9 more
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Molecules, 2022 During tumor angiogenesis different growth factors, cytokines and other molecules interact closely with each other to facilitate tumor cell invasion and metastatic diffusion.
Lorenzo Baldini +3 more
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Molecules, 2021 sp2-Iminosugar glycolipids (sp2-IGLs) represent a consolidated family of glycoconjugate mimetics encompassing a monosaccharide-like glycone moiety with a pseudoamide-type nitrogen replacing the endocyclic oxygen atom of carbohydrates and an axially ...
Elena M. Sánchez-Fernández +7 more
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Multitargeting nature of muscarinic orthosteric agonists and antagonists
Frontiers in Physiology, 2022 Muscarinic receptors (mAChRs) are typical members of the G protein-coupled receptor (GPCR) family and exist in five subtypes from M1 to M5. Muscarinic receptor subtypes do not sufficiently differ in affinity to orthosteric antagonists or agonists ...
Jaromir Myslivecek
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Multitarget tracking using the joint multitarget probability density [PDF]
IEEE Transactions on Aerospace and Electronic Systems, 2005 This work addresses the problem of tracking multiple moving targets by recursively estimating the joint multitarget probability density (JMPD). Estimation of the JMPD is done in a Bayesian framework and provides a method for tracking multiple targets which allows nonlinear target motion and measurement to state coupling as well as nonGaussian target ...
C. Kreucher, K. Kastella, A.O. Hero
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