Results 41 to 50 of about 34,376 (260)

MCE 2018: The 1st Multi-target Speaker Detection and Identification Challenge Evaluation

, 2019
The Multi-target Challenge aims to assess how well current speech technology is able to determine whether or not a recorded utterance was spoken by one of a large number of blacklisted speakers.
Dehak, Najim, Glass, James, Reynolds, Douglas, Shon, Suwon   +3 more
core   +1 more source

Recent advances in managing differentiated thyroid cancer [PDF]

, 2018
The main clinical challenge in the management of thyroid cancer is to avoid over-treatment and over-diagnosis in patients with lower-risk disease while promptly identifying those patients with more advanced or high-risk disease requiring aggressive ...
Durante, Cosimo, Filetti, Sebastiano, Grani, Giorgio, Lamartina, Livia   +3 more
core   +2 more sources

An AI‐Enabled All‐In‐One Visual, Proximity, and Tactile Perception Multimodal Sensor

Advanced Robotics Research, EarlyView.
Targeting integrated multimodal perception of robots, an AI‐enabled all‐in‐one multimodal sensor is proposed. This sensor is capable of perceiving three types of modalities, including vision, proximity, and tactility. By toggling an ultraviolet light and adjusting the camera focus, it switches smoothly between multiple perceptual modalities, enabling ...
Menghao Pu, Tiyong Zhao, Lingxi Zhang, Chaoqun Han, Zhiping Chai, Yifan Zhou, Han Ding, Zhigang Wu   +7 more
wiley   +1 more source

Design, Synthesis, and In Vitro Evaluation of Novel 8-Amino-Quinoline Combined with Natural Antioxidant Acids

Pharmaceuticals, 2022
Overproduction of reactive oxygen species (ROS) and alterations in metallostasis are common and related hallmarks in several neurodegenerative diseases (NDDs).
Andrea Bacci, Francesca Corsi, Massimiliano Runfola, Simona Sestito, Ilaria Piano, Clementina Manera, Giuseppe Saccomanni, Claudia Gargini, Simona Rapposelli   +8 more
doaj   +1 more source

Two-layer particle filter for multiple target detection and tracking [PDF]

, 2012
This paper deals with the detection and tracking of an unknown number of targets using a Bayesian hierarchical model with target labels. To approximate the posterior probability density function, we develop a two-layer particle filter.
García Fernández, Ángel Froilán, Grajal de la Fuente, Jesús, Morelande, Mark R.   +2 more
core   +1 more source

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong, Wenting Hui, Sai Qiao, Qifeng Ji, Miao Liu, Bangle Zhang, Daozhou Liu, Yumei Wu, Siyuan Zhou   +8 more
wiley   +1 more source

Small Multitarget Molecules Incorporating the Enone Moiety

Molecules, 2019
Chalcones represent a class of small drug/druglike molecules with different and multitarget biological activities. Small multi-target drugs have attracted considerable interest in the last decade due their advantages in the treatment of complex and ...
Thalia Liargkova, Nikolaos Eleftheriadis, Frank Dekker, Efstathia Voulgari, Constantinos Avgoustakis, Marina Sagnou, Barbara Mavroidi, Maria Pelecanou, Dimitra Hadjipavlou-Litina   +8 more
doaj   +1 more source

Polyphenols from Brown Seaweeds (Ochrophyta, Phaeophyceae): Phlorotannins in the Pursuit of Natural Alternatives to Tackle Neurodegeneration

Marine Drugs, 2020
Globally, the burden of neurodegenerative disorders continues to rise, and their multifactorial etiology has been regarded as among the most challenging medical issues.
Mariana Barbosa, Patrícia Valentão, Paula B. Andrade   +2 more
doaj   +1 more source

Construction of a MOF‐Based Snap‐Top Delivery Nanosystem for Powerful Dual‐Responsive Synergistic Colitis Treatment

Advanced Science, EarlyView.
A snap‐top delivery nanosystem based on an azobenzene metal–organic framework achieves targeted release of 6‐mercaptopurine via acid‐stable frameworks and hypoxia/pH dual‐responsive β‐cyclodextrin gates. This multifunctional platform integrates three synergistic mechanisms: precision drug delivery to inflammatory sites, intrinsic antioxidant properties
Xin Li, Miao Xu, Heran Li, Huan Jiang, Xin Wang, Lianjun Ma, Ying‐Wei Yang   +6 more
wiley   +1 more source

Dehydrodieugenol Neolignans as Multitarget Anti-Inflammatory Agents: sPLA2 Inhibition and Therapeutic Implications

Drugs and Drug Candidates
Background/Objectives: The study investigated the anti-inflammatory potential of neolignan derivatives of dehydrodieugenol (CP1–CP5), focusing on the inhibition of secretory phospholipase A2 (sPLA2), a key enzyme in inflammation.
Adeilso B. Santos Junior, Caroline R. C. Costa, João H. G. Lago, Airam Roggero, Igor N. Oliveira, Danilo R. S. Lima, Paloma P. Borges, Willian H. B. C. Santos, Marcos A. Oliveira, Sérgio F. Sousa, Marcos H. Toyama   +10 more
doaj   +1 more source