Results 51 to 60 of about 34,376 (260)

Multifunctional Cinnamic Acid Derivatives

Molecules, 2017
Our research to discover potential new multitarget agents led to the synthesis of 10 novel derivatives of cinnamic acids and propranolol, atenolol, 1-adamantanol, naphth-1-ol, and (benzylamino) ethan-1-ol.
Aikaterini Peperidou, Eleni Pontiki, Dimitra Hadjipavlou-Litina, Efstathia Voulgari, Konstantinos Avgoustakis   +4 more
doaj   +1 more source

Novel Series of Dual NRF2 Inducers and Selective MAO-B Inhibitors for the Treatment of Parkinson’s Disease

Antioxidants, 2022
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease. It is characterized by a complex network of physiopathological events where oxidative stress plays a central role among other factors such as neuroinflammation and protein ...
Pablo Duarte, Patrycja Michalska, Enrique Crisman, Antonio Cuadrado, Rafael León   +4 more
doaj   +1 more source

Multitarget Drug Discovery and Polypharmacology [PDF]

ChemMedChem, 2016
Promising promiscuity: Guest editors Maria Laura Bolognesi and Andrea Cavalli set the stage for this ChemMedChem Special Issue on Polypharmacology and Multitarget Drugs. They highlight cases in which a departure from the "one target, one drug" paradigm has proven advantageous, with single molecules that can engage two or more targets to address a given
BOLOGNESI, MARIA LAURA, CAVALLI, ANDREA
openaire   +3 more sources

Targeting ANGPTL3 and IL‐33/ST2 Ameliorates Diabetic Kidney Disease by Reducing Lipotoxicity, Alleviating Inflammation and Inhibiting Fibrosis

Advanced Science, EarlyView.
Dual targeting of ANGPTL3 and IL‐33/ST2 attenuates diabetic kidney disease by reprogramming lipid–inflammatory crosstalk. This strategy reduces renal lipotoxicity, suppresses inflammatory activation, and limits fibrotic remodeling, thereby preserving kidney structure and function and highlighting a mechanism‐guided therapeutic approach for metabolic ...
Zhuojin Li, Zhonglian Cao, Rongrui Zhou, Xu Cheng, Xiaozhi Hu, Shuwen Xu, Zihan Dou, Ling Du, Dianwen Ju   +8 more
wiley   +1 more source

Structure Activity Relationships of Multitarget Coumarins on Inhibitory Aggregation of Platelets: An Integrated In Vitro and In Silico Study

Biophysica
Novel pharmacological approaches advocate developing multitarget drugs, that is, molecules capable of simultaneously acting on two or more pharmacological targets to produce synergistic effects from a single compound in each disease.
Ixchel Ramírez-Camacho, Fernando León Cedeño, José Germán Vázquez Cuevas, Eva Florencia Lejarazo Gómez, Ulises Martínez-Ortega, Mirthala Flores-García, Ana María Mejía-Domínguez, Aurora de la Peña-Díaz, Fausto Alejandro Jiménez-Orozco   +8 more
doaj   +1 more source

The Necessity of Dynamic Workflow Managers for Advancing Self‐Driving Labs and Optimizers

Advanced Intelligent Discovery, EarlyView.
We assess the maturity and integration readiness of key methodologies for Materials Acceleration Platforms, highlighting the need for dynamic workflow managers. Demonstrating this, we integrate PerQueue into a color‐mixing robot, showing how flexible orchestration improves coordination and optimization.
Simon K. Steensen, Patrick W. V. Butler, Jesper R. Pedersen, Nis Fisker‐Bødker, Tejs Vegge, Jin Hyun Chang, Ivano E. Castelli   +6 more
wiley   +1 more source

Exploration of Moringa Oleifera and Curcuma Longa Compounds as Multi-Target Agents for Alzheimer’s Disease Through Bioinformatics Analysis

Scripta Score Scientific Medical Journal
Background: Alzheimer’s disease is a multifactorial neurodegenerative disorder. Current synthetic inhibitors often fail to address its complexity. Natural multitarget agents like Moringa oleifera and Curcuma longa may offer safer alternatives. Objective:
Shakira, Meutia Maulina
doaj   +1 more source

Discovery of Multitarget-Directed Ligands Against Influenza A Virus From Compound Yizhihao Through a Predictive System for Compound-Protein Interactions

Frontiers in Cellular and Infection Microbiology, 2020
Influenza A virus (IAV) is a threat to public health due to its high mutation rate and resistance to existing drugs. In this investigation, 15 targets selected from an influenza virus–host interaction network were successfully constructed as a ...
Lvjie Xu, Wen Jiang, Hao Jia, Lishu Zheng, Jianguo Xing, Ailin Liu, Guanhua Du   +6 more
doaj   +1 more source

Multi-Bernoulli Sensor-Control via Minimization of Expected Estimation Errors

, 2015
This paper presents a sensor-control method for choosing the best next state of the sensor(s), that provide(s) accurate estimation results in a multi-target tracking application.
Bab-Hadiashar, Alireza, Gostar, Amirali K., Hoseinnezhad, Reza   +2 more
core   +1 more source

A second-order PHD filter with mean and variance in target number [PDF]

, 2017
The Probability Hypothesis Density (PHD) and Cardinalized PHD (CPHD) filters are popular solutions to the multi-target tracking problem due to their low complexity and ability to estimate the number and states of targets in cluttered environments.
Clark, Daniel E., Delande, Emmanuel D., Houssineau, Jeremie, Schlangen, Isabel   +3 more
core   +4 more sources