Results 61 to 70 of about 34,376 (260)

Machine Learning‐Enhanced Random Matrix Theory Design for Human Immunodeficiency Virus Vaccine Development

Advanced Intelligent Discovery, EarlyView.
This study integrates random matrix theory (RMT) and principal component analysis (PCA) to improve the identification of correlated regions in HIV protein sequences for vaccine design. PCA validation enhances the reliability of RMT‐derived correlations, particularly in small‐sample, high‐dimensional datasets, enabling more accurate detection of ...
Mariyam Siddiqah, Muhammad Zulqarnain Zeb, Muhammad Husnain Zeb, Babar Shabbir   +3 more
wiley   +1 more source

In Silico Studies on Compounds Derived from Calceolaria: Phenylethanoid Glycosides as Potential Multitarget Inhibitors for the Development of Pesticides

Biomolecules, 2018
An increasing occurrence of resistance in insect pests and high mammal toxicity exhibited by common pesticides increase the need for new alternative molecules.
Marco A. Loza-Mejía, Juan Rodrigo Salazar, Juan Francisco Sánchez-Tejeda   +2 more
doaj   +1 more source

A Review of the Development of Multitarget Molecules against HIV-TB Coinfection Pathogens

Molecules, 2023
The human immunodeficiency virus (HIV) produces the pathologic basis of acquired immunodeficiency syndrome (AIDS). An increase in the viral load in the body leads to a decline in the number of T lymphocytes, compromising the patient’s immune system. Some
Debora Inacio Leite, Stefany de Castro Bazan Moura, Maria da Conceição Avelino Dias, Carolina Catta Preta Costa, Gustavo Peixoto Machado, Luiz Claudio Ferreira Pimentel, Frederico Silva Castelo Branco, Rui Moreira, Monica Macedo Bastos, Nubia Boechat   +9 more
doaj   +1 more source

RT‐DETR‐DA for Complex Scenes: Distracted Driving Detection With Feature Interaction and Dynamic Perception

Advanced Intelligent Systems, EarlyView.
This work proposes RT‐DETR‐DA, an enhanced real‐time detection framework for identifying distracted driving in complex, real‐world environments. The model introduces a dynamic sparse gating multiscale attention module and an attention‐guided dual‐path fusion module to strengthen multiscale perception and cross‐layer feature interaction.
Yi Liu, QiaoXing Li, XiBin Wang, Ying He, Sen Zhang   +4 more
wiley   +1 more source

Putative mechanism of a multivitamin treatment against insulin resistance

Adipocyte
Insulin resistance is caused by the abnormal secretion of proinflammatory cytokines in adipose tissue, which is induced by an increase in lipid accumulation in adipocytes, hepatocytes, and myocytes. The inflammatory pathway involves multiple targets such
José Antonio Palma-Jacinto, Edgar López-López, José Luis Medina-Franco, Oreth Montero-Ruíz, Isela Santiago-Roque   +4 more
doaj   +1 more source

Multi-Target Cinnamic Acids for Oxidative Stress and Inflammation: Design, Synthesis, Biological Evaluation and Modeling Studies

Molecules, 2018
Inflammation is a complex phenomenon that results as a healing response of organisms to different factors, exerting immune signaling, excessive free radical activity and tissue destruction.
Eleni Pontiki, Dimitra Hadjipavlou-Litina   +1 more
doaj   +1 more source

CPHD filter derivation for extended targets [PDF]

, 2010
This document derives the CPHD filter for extended targets. Only the update step is derived here. Target generated measurements, false alarms and prior are all assumed to be independent identically distributed cluster processes.
Orguner, Umut
core  

Research progress on biomarkers of traumatic brain injury

Animal Models and Experimental Medicine, EarlyView.
Traumatic brain injury: From primary insult to secondary neuroinflammation and degeneration. Abstract Traumatic brain injury (TBI) is a common disorder of the nervous system and has become a leading cause of death and disability worldwide, imposing a substantial burden on patients and their social circles. Its main symptoms include dyskinesia, language
Xuting Shen, Si Cheng, Shuyi Chen, Mengyue Wang, Tangying Li, Weicheng Xu, Yifan Zhang, Ping Yuan, Lei Shi   +8 more
wiley   +1 more source

From Lipid Regulation to Neuroprotection: Multitarget (Benzo)thiazine Derivatives as Promising Leads

Molecules
Neurodegenerative and cardiovascular disorders share multifactorial origins, including oxidative stress, (neuro)inflammation, and lipid dysregulation—factors often addressed independently by single-target therapies.
Ariadni Tzara, Andrea Andreou, Angeliki P. Kourounakis   +2 more
doaj   +1 more source

Multitarget sequential sputtering apparatus [PDF]

, 1975
The development and characteristics of a sputtering apparatus are discussed. A potential difference is applied between the cathode and anode to produce a plasma for each target which is sputtered by accelerated ions within the plasma.
Shima, R.
core   +1 more source