Results 11 to 20 of about 34,376 (260)
Andrographolide, an Anti-Inflammatory Multitarget Drug: All Roads Lead to Cellular Metabolism
Molecules, 2020 Andrographolide is a labdane diterpene and the main active ingredient isolated from the herb Andrographis paniculata. Andrographolide possesses diverse biological effects including anti-inflammatory, antioxidant, and antineoplastic properties.
Rafael Agustín Burgos +4 more
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Frontiers in Pharmacology, 2021 Objectives: Zeel T (Ze14) is a multicomponent medicinal product. Initial preclinical data suggested a preventive effect on cartilage degradation. Clinical observational studies demonstrated that Ze14 reduced symptoms of osteoarthritis (OA), including ...
Christelle Sanchez +9 more
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Pharmaceuticals, 2023 Alternative medicines, especially herbal remedies, have been employed to treat infections and metabolism-related chronic inflammation because their safety and multidimensional therapeutic potential outweigh those of synthetic drugs. So Shiho Tang (SSHT),
Nguyen Khoi Song Tran +4 more
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Multitarget Tracking with Doppler Ambiguity [PDF]
IEEE Transactions on Aerospace and Electronic Systems, 2013 A new approach for multitarget detection and tracking with Doppler ambiguity is presented. Ambiguous Doppler measurements, in addition to the position measurements, are directly used in data association and tracking. Based on the unscented Kalman filter (UKF), the multiple hypothesis tracking (MHT) algorithm and the probabilistic data association (PDA)
K. Li +4 more
openaire +1 more source
Trajectory probability hypothesis density filter [PDF]
, 2018 This paper presents the probability hypothesis density (PHD) filter for sets of trajectories: the trajectory probability density (TPHD) filter. The TPHD filter is capable of estimating trajectories in a principled way without requiring to evaluate all ...
García-Fernández, Ángel F. +1 more
core +2 more sources
Multitargeted therapies for multiple myeloma [PDF]
Autophagy, 2013 Multiple myeloma (MM) comprises 1% of all malignancies and 10% of all hematological malignancies. MM is a malignancy of plasma cells in the bone marrow where complex and dynamic interactions with the bone marrow microenvironment lead to tumor progression, skeletal destruction and angiogenesis.
Pedram, Kharaziha +3 more
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Molecules, 2018 A series of macrocyclic pyrido-pentapeptide candidates 2–6 were synthesized by using N,N-bis-[1-carboxy-2-(benzyl)]-2,6-(diaminocarbonyl)pyridine 1a,b as starting material.
Abd El-Galil E. Amr +5 more
doaj +1 more source
Multitarget Vulnerable Plaque Imaging [PDF]
Circulation: Cardiovascular Imaging, 2017 The search for the vulnerable plaque has been a prolonged, circuitous journey that despite considerable investment and resource expenditure has hitherto failed to alter clinical practice. The rationale remains enticing. We have known for some time that plaques at risk of rupture and precipitating myocardial infarction and stroke have certain ...
Marc R, Dweck, Zahi A, Fayad
openaire +2 more sources
Reconsidering Aromatase for Breast Cancer Treatment: New Roles for an Old Target
Molecules, 2020 The current therapeutic approach for the treatment of hormone dependent breast cancer includes interference with estrogen receptors via either selective modulators or estrogens deprivation, by preventing their biosynthesis with aromatase inhibitors ...
Jessica Caciolla +4 more
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Pharmaceuticals, 2021 Alzheimer’s disease (AD) is a progressive neurological disorder that affects 50 million people. Despite this, only two classes of medication have been approved by the FDA. Therefore, we have planned to develop therapeutics by multitarget approach.
Danish Iqbal +9 more
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