Results 51 to 60 of about 25,002 (268)

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

Multitarget Molecular Hybrids of Cinnamic Acids

Molecules, 2014
In an attempt to synthesize potential new multitarget agents, 11 novel hybrids incorporating cinnamic acids and paracetamol, 4-/7-hydroxycoumarin, benzocaine, p-aminophenol and m-aminophenol were synthesized.
Aikaterini Peperidou, Dorothea Kapoukranidou, Christos Kontogiorgis, Dimitra Hadjipavlou-Litina   +3 more
doaj   +1 more source

Novel mechanisms in the regulation of 5-lipoxygenase gene expression by 1,25-dihydroxyvitamin D3 and transforming growth factor ß [PDF]

, 2004
Die 5 Lipoxygenase (5 LO) ist das Schlüsselenzym in der Synthese von Leukotrienen. Sie wird auf transkriptioneller und posttranskriptioneller Ebene reguliert.
Seuter, Sabine
core  

Sulfated Cyclocarya Paliurus Polysaccharide Sorchestrates the Gut Microbiome to Mobilize a Host‐Derived 12‐HEPE Against Ulcerative Colitis

Advanced Science, EarlyView.
A sulfated polysaccharide (SCP) from Cyclocarya paliurus alleviates ulcerative colitis by reshaping the gut microbiome. This remodeled microbiota orchestrates the upregulation of the host‐derived lipid 12‐HEPE, which directly inhibits the TLR4/NF‐κB pathway to suppress inflammation.
Xianxiang Chen, Mingyue Shen, Rui Zhang, Zhibing Huang, Hui Niu, Qiang Yu, Yi Chen, Xiangwen Pan, Liyuan Rong, Huiliang Wen, Jun Yang, Jianhua Xie   +11 more
wiley   +1 more source

The Impact of Helicobacter pylori Urease upon Platelets and Consequent Contributions to Inflammation

Frontiers in Microbiology, 2017
Gastric infection by Helicobacter pylori is considered a risk factor for gastric and duodenal cancer, and extragastric diseases. Previous data have shown that, in a non-enzymatic way, H.
Adriele Scopel-Guerra, Deiber Olivera-Severo, Deiber Olivera-Severo, Fernanda Staniscuaski, Fernanda Staniscuaski, Augusto F. Uberti, Augusto F. Uberti, Natália Callai-Silva, Natália Jaeger, Bárbara N. Porto, Celia R. Carlini   +10 more
doaj   +1 more source

Docking Studies and Molecular Dynamics Simulation of Compounds Contained in Kaempferia Galanga L. to Lipoxygenase (LOX) for Anti-Inflammatory Drugs

Journal of Mathematical and Fundamental Sciences, 2021
Inflammation is a self-protective response to start the healing process. An anti-inflammatory target worth developing are lipoxygenase inhibitors, which have been studied for several diseases, including severe respiratory disease.
Supandi Supandi, Yeni Yeni, Lusi Putri Dwita   +2 more
doaj   +1 more source

Recent advances in the search for novel 5-lipoxygenase inhibitors for the treatment of asthma [PDF]

, 2017
The products of 5-lipoxygenase are synthesized and released in the airway when an asthmatic reaction occurs. 5-lipoxygenase via arachidonic acid metabolism produces leukotrienes that mediate bronchoconstriction and inflammatory modifications essential in
Sureda, Antoni, Seyed Mohammed Nabavi, Filosa, Rosanna, Roviezzo, Fiorentina, Spaziano, Giuseppe, Antoni Sureda, Ferdinando Bruno, Giuseppe Spaziano, Fiorentina Roviezzo, Liparulo, Angela, Rosanna Filosa, Angela Liparulo, Bruno D'Agostino, Nabavi, Seyed Mohammed, D'Agostino, Bruno, Bruno, Ferdinando   +15 more
core   +1 more source

Leptin May Promote Eosinophilic CRSwNP Progression by Enhancing Eosinophil Chemotaxis and Angiogenesis Under a Type 2 Inflammatory Milieu

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyp (CRSwNP) is a heterogeneous Type 2 inflammatory disease characterized by enhanced eosinophilic infiltration. Both innate and adaptive immunity are involved in the onset and progression of CRSwNP.
Yuki Sonoda, Yohei Sato, Yoshimasa Imoto, Mayumi Tamari, Shigeharu Fujieda   +4 more
wiley   +1 more source

Small Multitarget Molecules Incorporating the Enone Moiety

Molecules, 2019
Chalcones represent a class of small drug/druglike molecules with different and multitarget biological activities. Small multi-target drugs have attracted considerable interest in the last decade due their advantages in the treatment of complex and ...
Thalia Liargkova, Nikolaos Eleftheriadis, Frank Dekker, Efstathia Voulgari, Constantinos Avgoustakis, Marina Sagnou, Barbara Mavroidi, Maria Pelecanou, Dimitra Hadjipavlou-Litina   +8 more
doaj   +1 more source

Investigations into effects of 12-lipoxygenase and NADPH oxidase on platelet activity, and influences of dietary dark chocolate [PDF]

, 2012
PhDPlatelets play a pivotal role in both normal hemostasis and pathological bleeding and importantly also contribute to the development of atherothrombosis.
Zain, Zetty Nadia Mohd
core