Results 61 to 70 of about 25,002 (268)

Mechanistic investigation of Liujing Toutong tablet in the treatment of cerebral ischemia–reperfusion injury in rats by the integration of serum pharmacochemistry and metabolomics

Animal Models and Experimental Medicine, EarlyView.
The research strategy for pharmacodynamics, serum pharmacochemistry, metabolomics, and network pharmacology analysis method in intervention effects of LTT are illustrated. Abstract Background Liujing Toutong tablet (LTT) is a traditional Chinese patent medicine.
Zihan Yu, Ke Pei, Xiulin Wang, Wenling Li, Hongchang Li, Wangyang Xie, Xianglong Meng, Tingting Zhao, Yan Ning, Haixin Liu, Wenbin He   +10 more
wiley   +1 more source

Fundamental Concepts in the Assessment of Interaction of Biological Response Modifiers with other Agents

Canadian Journal of Infectious Diseases, 1992
The universal response surface approach (URSA) was developed to assess the nature and intensity of drug interactions, ie, synergism. antagonism and additivity.
William R Greco, Wlodzimierz E Dembinski
doaj   +1 more source

Evidence for a dominant role of lipoxygenase(s) in the oxidation of LDL by mouse peritoneal macrophages

Journal of Lipid Research, 1991
It has been suggested that the oxidative modification of low density lipoprotein (LDL) is a key event in atherogenesis. Several mechanisms have been proposed to explain how different types of cells modify LDL.
SM Rankin, S Parthasarathy, D Steinberg
doaj   +1 more source

Synthesis of new N-(5-chloro-2-methoxyphenyl)-4-(5-substituted-1,3,4-oxadiazol-2-ylthio)butanamide derivatives as suitable lipoxygenase inhibitors

Journal of Saudi Chemical Society, 2016
Heterocyclic compounds are the most attractive class for researchers due to their biological activities. In the undertaken research, a number of N-(5-chloro-2-methoxyphenyl)-4-(5-substituted-1,3,4-oxadiazol-2-ylthio)butanamide (6a–k) compounds were ...
Aziz-ur-Rehman, Ambreen Fatima, Muhammad Athar Abbasi, Shahid Rasool, Abdul Malik, Muhammad Ashraf, Irshad Ahmad, Syeda Abida Ejaz   +7 more
doaj   +1 more source

Pharmakologische Wirkmechanismen und Zielstrukturen von Boswelliasäuren in humanen Leukozyten und Thrombozyten [PDF]

, 2006
Boswellia serrata gum resin extracts (frankincense) have been used for centuries in folk medicine in Asia and Africa. They have shown beneficial therapeutic effects, particularly in the treatment of chronic inflammatory diseases.
Pöckel, Daniel
core  

Synthesis and evaluation of benzoxazole derivatives as 5-lipoxygenase inhibitors [PDF]

, 2010
5-Lipoxygenase (5-LOX) is important enzyme in the biosynthesis of leukotrienes, and is a potential target in the treatment of asthma and allergy. We designed and synthesized a series of benzoxazoles and benzothiazoles as 5-LOX inhibitors.
H K Rhee, G Han, K E Doh, Sei Ryang Oh, H Song, H W Chang, Hyeong Kyu Lee, J H Kim, H Y Park Choo   +8 more
core   +3 more sources

The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cells [PDF]

, 2008
Activated mast cells are a major source of the eicosanoids PGD(2) and leukotriene C(4) (LTC(4)), which contribute to allergic responses. These eicosanoids are produced following the ERK1/2-dependent activation of cytosolic phospholipase A(2), thus ...
Hye Sun Kuehn, Gilfillan, Alasdair M., Michael A. Beaven, Alasdair M. Gilfillan, Kuehn, Hye Sun, Dean D. Metcalfe, Beaven, Michael A., Emily J. Swindle, Swindle, Emily J., Mi-Sun Kim, Kim, Mi-Sun, Metcalfe, Dean D.   +11 more
core   +1 more source

Quantum Phenomena in Molecular and Biological Systems: A Decoherence‐Based Decision Framework With Falsifiable Predictions and a Failure‐Mode Taxonomy

Advanced Physics Research, EarlyView.
A physics‐grounded framework based on decoherence timescales (τ_dec vs τ_func), Markovian validity, and falsifiability criteria is applied across molecular systems to distinguish where quantum effects are necessary, marginal, or irrelevant. The analysis integrates quantum chemistry, biological quantum mechanisms, and quantum computing under a unified ...
Sarfaraz K. Niazi
wiley   +1 more source

Ursolic Acid Alleviates Orchitis via Modulating Ferroptosis in Peritubular Myoid Cells of Testis

Animal Research and One Health, EarlyView.
Ursolic acid modulates key ferroptosis‐related pathways in the peritubular myoid cells of the testis in forest musk deer. ABSTRACT Chronic stress adversely affects reproductive health, increasing susceptibility to pathologies such as orchitis. Additionally, the maintenance of iron homeostasis is essential for preserving the function of the testicles ...
Yang Wang, Tianqi Jin, Zexin Chen, Ye Gong, Qimin Liu, Zifang Wu, Heran Cao, Yan Li, Yuyan Liu, Tianhao Yang, Zhihong Jiang, Wuzi Dong   +11 more
wiley   +1 more source

Synthesis and Antioxidant Activities of Novel Pyrimidine Acrylamides as Inhibitors of Lipoxygenase: Molecular Modeling and In Silico Physicochemical Studies

Molecules
The pyrimidine ring is present in various biomolecules such as DNA and RNA bases, aminoacids, vitamins, etc. Additionally, many clinically used drugs including methotrexate and risperidone contain the pyrimidine heterocyclic scaffold as well.
Michail Saragatsis, Eleni Pontiki
doaj   +1 more source