Results 71 to 80 of about 16,348 (221)
Potential role of the lipoxygenase derived lipid mediators in atherosclerosis: leukotrienes, lipoxins and resolvins [PDF]
, 2017 Atherogenesis is an inflammatory process with leukocytes infiltrating the arterial intima. The lipoxygenase pathways play a role in leukocyte recruitment through the generation of two classes of arachidonic acid lipid mediators, the leukotrienes and the ...
Hersberger, Martin
core
Arachidonic Acid Regulates the Translocation of 5-Lipoxygenase to the Nuclear Membranes in Human Neutrophils [PDF]
Journal of Biological Chemistry, 2006 Elevation of the intracellular cAMP concentration in agonist-activated human neutrophils (PMN) leads to the concomitant inhibitions of arachidonic acid (AA) release, 5-lipoxygenase (5-LO) translocation, and leukotriene (LT) biosynthesis. We report herein that exogenous AA completely prevents cAMP-dependent inhibition of 5-LO translocation and LT ...
Nicolas, Flamand +4 more
openaire +2 more sources
Ferroptotic neurodegeneration and diet: a narrative review
Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.Dietary regimes and separate components have been reported to reduce ferroptosis by (1) altering iron metabolism, (2) increasing antioxidant defense, and (3) reducing lipid peroxidation. This ultimately leads to reduced ferroptosis and neurodegeneration.
Ximaine R. van der Burg +4 more
wiley +1 more source
Eculizumab treatment alters the proteometabolome beyond the inhibition of complement
JCI Insight, 2023 Therapeutic strategies targeting complement have revolutionized the treatment of myasthenia gravis (MG). However, a deeper understanding of complement modulation in the human system is required to improve treatment responses and identify off-target ...
Christopher Nelke +14 more
doaj +1 more source
Lipid Mediators in Inflammation [PDF]
, 2016 Lipids are potent signaling molecules that regulate a multitude of cellular responses, including cell growth and death and inflammation/infection, via receptor-mediated pathways. Derived from polyunsaturated fatty acids (PUFAs), such as arachidonic acid (
Bennett, M, Gilroy, DW
core +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.Sevoflurane exposure triggers iron‐dependent lipid peroxidation and ferroptosis, leading to synaptic damage and cognitive dysfunction. Targeted nanodelivery systems that cross the blood–brain barrier can precisely modulate ferroptotic pathways, reduce oxidative injury, and rescue synaptic integrity, offering a promising strategy for preventing ...
Bin Zhao, Changming Wang, Mingming Zhang
wiley +1 more source
PLoS ONE, 2014 Pulmonary Hypertension (PH) is a progressive disorder characterized by endothelial dysfunction and proliferation. Hypoxia induces PH by increasing vascular remodeling. A potential mediator in hypoxia-induced PH development is arachidonate 5-Lipoxygenase (
Kristi M Porter +5 more
doaj +1 more source
AGER-Mediated Lipid Peroxidation Drives Caspase-11 Inflammasome Activation in Sepsis
Frontiers in Immunology, 2019 Inflammasome activation can trigger an inflammatory and innate immune response through the release of cytokines and induction of pyroptosis. A dysfunctional inflammasome has been implicated in the development of human pathologies, including sepsis and ...
Ruochan Chen +9 more
doaj +1 more source
A high-throughput mass spectrometric assay for discovery of human lipoxygenase inhibitors and allosteric effectors. [PDF]
, 2015 Lipoxygenases (LOXs) regulate inflammation through the production of a variety of molecules whose specific downstream effects are not entirely understood due to the complexity of the inflammation pathway.
Holman, Theodore R +2 more
core +1 more source
One of the 5-aminosalicylates drug, mesalamine as a drug repurposing lead against breast cancer
Bulletin of the National Research Centre, 2022 Background Breast cancer is the world's second leading cause of death in women. The problem of chemoresistance in breast cancer is proving to be a challenge for researchers and several oncologists all around the world.
Dayanand Swami +4 more
doaj +1 more source