Results 301 to 310 of about 5,110,374 (337)
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Biological Nitration of Arachidonic Acid
Current Vascular Pharmacology, 2004When a spontaneous autoxidation of arachidonic acid to prostaglandin-like products was first described almost 40 years ago, it was thought to be an artifact that interfered with the detection of enzymatically generated prostaglandins. It has now been generally accepted that the autoxidation of arachidonic acid occurs in vivo and leads to formation of ...
Candace D Poff, Michael Balazy
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Glucagon and plasma arachidonic acid
Metabolism, 1965Abstract Previous work has shown the presence of a factor in the external pancreatic secretion of dogs distinct from the enzymes that affect plasma arachidonic acid. Removal of the exocrine factor by pancreatectomy or pancreatic duct ligation resulted in depression of arachidonic acid in all plasma lipid fractions which could not be corrected by ...
Raymond Caren, Lucille Corbo
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Psoriasis and the arachidonic acid cascade
Journal of Dermatological Science, 1999Arachidonic acid (5.8,11,14-eicosatetraenoic acid C20:4, n-6) is released from the cell membrane by the action of phospholipases on membrane phospholipids. Metabolites of arachidonic acid, which are generically termed eicosanoids, including prostaglandins, thromboxane, leukotrienes and hydroxyeicosatetraenoic acids, have been implicated as mediators or
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Biologic Importance of Arachidonic Acid [PDF]
Archives of Internal Medicine, 1981 The most abundant prostaglandin precursor is arachidonic acid (or its precursor, linoleic acid). The isolation and identification of prostaglandin compounds in a particular tissue, knowledge of the biologic properties of these compounds, and the use of readily available inhibitors of the prostaglandin pathway by aspirin-like drugs constitute the main ...
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THE METABOLISM OF FATTY ACIDS IN THE RAT. VI. ARACHIDONIC ACID.
Acta Physiologica Scandinavica, 1965Goransson, G. The metabolism of fatty acids in the rat. VI. Arachidonic acid. Acta physiol. scand. 1965. 64. 1–5. -H3-labeled arachidonic acid and C14-labeled palmitic acid were simultaneously injected into male rats.
G. Göransson
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Vasoactivity of arachidonic acid epoxides
European Journal of Pharmacology, 1987Arachidonic acid (AA) can be metabolized to epoxides and their corresponding diols via the cytochrome P450 epoxygenase pathway. We have compared the vascular activity of four synthetically prepared epoxyeicosatrienoic acids, i.e. 5,6-, 8,9-, 11,12- and 14,15-EET (2-20 microM) on the isolated perfused rat tail artery.
Mairead A. Carroll +4 more
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1996
Arachidonic acid belongs to that relatively small group of chemical substances which were selected in the course of biological evolution to act as informational molecules. These signals are essential for the survival of free-living cells and for coordinating the complex needs of multicellular organisms: as adaptive demands and cell functions changed ...
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Arachidonic acid belongs to that relatively small group of chemical substances which were selected in the course of biological evolution to act as informational molecules. These signals are essential for the survival of free-living cells and for coordinating the complex needs of multicellular organisms: as adaptive demands and cell functions changed ...
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Regulation and metabolism of arachidonic acid
Clinical Reviews in Allergy & Immunology, 1999The metabolism of AA reflects a carefully balanced series of biochemical pathways. The level of free arachidonate in a cells is controlled by de novo synthesis, dietary uptake, and transcellular metabolism. Lysophospholipids are key controlling substrates for a variety of acyl transferase and transacylase reactions, whose combined effect is to remodel ...
Michael C. Seeds, David A. Bass
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Arachidonic acid maldistribution in obesity
Lipids, 1996AbstractArachidonic acid is an important regulator of cellular function via its effects on the physical properties of membranes, in its free form, or as a substrate for eicosanoids. Dietary studies indicate that its production is regulated, but the mechanisms of this regulation and factors influencing arachidonate distribution from the site of ...
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Arachidonic acid and eicosanoid release
Journal of Immunological Methods, 1994The major techniques for the study and determination of eicosanoid metabolism in eukaryotic cells will be described. These techniques include the determination of free arachidonic acid and its metabolites in biological fluids and cell media by immunochemical techniques (RIA, ELISA) and by HPLC.
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