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Arachidonic acid metabolism

Preventive Medicine, 1987
Arachidonic acid metabolites can act as tumor promoters and can affect growth and metastases of tumors in three ways: (a) Prostacyclin inhibits and thromboxane facilitates platelet-tumor cell interactions and, thereby, tumor cell invasiveness; (b) the cytoprotective action of prostaglandins contributes to epithelial cell integrity and influences tissue
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Arachidonic acid production by microorganisms

Biotechnology and Applied Biochemistry, 1992
Arachidonic acid (AA) is a natural precursor of prostaglandins, thromboxanes, leukotrienes, prostacyclins, and a large group of C20 compounds which are of intrinsic medical interest. At present, the only source of AA is animal tissues. However, it is present in several microorganisms. This review describes the production of AA by microorganisms and its
Pratima Bajpai, Pramod K. Bajpai
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CHEMIEXCITATION IN THE ARACHIDONIC ACID CASCADE

Photochemistry and Photobiology, 1991
Abstract—As investigated in neutrophils, the very weak luminescence accompanying the arachidonic acid cascade is associated with the lipoxygenase pathway. The emission is dramatically enhanced by energy transfer to chlorophylla. The number of chlorophyll molecules excited to the fluorescent state per oxygen consumed, (the S1/O2ratio), equal to the ...
Ana L. T. O. Nascimento   +1 more
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Renal Arachidonic Acid Metabolism

Annual Review of Physiology, 1984
Renal prostaglandin synthesis has been the focus of extensive investigation during the past decade. This chapter reviews the cellular localization of renal arachidonic acid metabolism in view of the substantial recent progress in the isolation and culture of renal cell types.
Mark G. Currie, Philip Needleman
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Arachidonic acid aggregates neutrophils

Inflammation, 1979
Arachidonic acid, but not several structurally similar fatty acids, stimulated neutrophils in suspension to aggregate; this effect was blocked by 5, 8, 11, 14-eicosatetraynoic acid, an inhibitor of arachidonic acid metabolism. Analagous to platelets, arachidonate may be a precursor of active metabolites which mediate neutrophil responses.
Elmer L. Becker   +3 more
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THE METABOLISM OF FATTY ACIDS IN THE RAT. VI. ARACHIDONIC ACID.

Acta Physiologica Scandinavica, 1965
Goransson, G. The metabolism of fatty acids in the rat. VI. Arachidonic acid. Acta physiol. scand. 1965. 64. 1–5. -H3-labeled arachidonic acid and C14-labeled palmitic acid were simultaneously injected into male rats.
G. Göransson
semanticscholar   +1 more source

P-450 metabolites of arachidonic acid in the control of cardiovascular function.

Physiological Reviews, 2002
Recent studies have indicated that arachidonic acid is primarily metabolized by cytochrome P-450 (CYP) enzymes in the brain, lung, kidney, and peripheral vasculature to 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs) and ...
R. Roman
semanticscholar   +1 more source

Interactions of zinc and arachidonic acid

Prostaglandins and Medicine, 1981
To probe the interaction of zinc with polyunsaturated fatty acids we have studied the effect of zinc on the cooxygenation of ferrous iron and arachidonic acid. Zinc inhibited the process of cooxygenation in a concentration dependent fashion. Further evaluation of the interaction of zinc and arachidonic acid gave spectroscopic evidence that zinc, oxygen
J.G. White   +4 more
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Preparation of deuterated arachidonic acid

Prostaglandins, 1981
Publisher Summary It is reported preparation of [ 2 H 8 ]arachidonic acid from the precursor tetraacetylene eicosatetraynoic procedures gave rise to substantial double-bond isomerization and isotopic scrambling, leading to mixtures that yielded after purification only small quantities of the desired product.
Mark A. Phillips   +2 more
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Arachidonic acid and colorectal carcinogenesis

Molecular and Cellular Biochemistry, 2003
Colorectal carcinoma is a leading cause of cancer related death worldwide. This deadly disease advances through a series of clinical and histopathological stages, initiated by single crypt lesions to small benign tumors and finally to malignancy. Although some progress has been made in elucidating the formation of colorectal tumors at molecular/genetic
Siddhartha Das   +4 more
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