Results 341 to 350 of about 5,117,744 (378)

Arachidonic acid and other fatty acids directly activate potassium channels in smooth muscle cells.

Science, 1989
Arachidonic acid, as well as fatty acids that are not substrates for cyclooxygenase and lipoxygenase enzymes, activated a specific type of potassium channel in freshly dissociated smooth muscle cells.
R. Ordway, J. Walsh, J. J. Singer
semanticscholar   +1 more source

Plasma arachidonic acid and the pancreas

Journal of Atherosclerosis Research, 1964
Summary This work provides evidence in support of the presence of a factor in the exocrine pancreatic secretion of the dog which regulates the percent composition of plasma arachidonic acid by its action on the cholesterol ester and phospholipid fractions primarily. The factor is distinct from pancreatic enzymes, is heat-stable, and requires adequate
L. Corbo, R. Caren
openaire   +3 more sources

Biological Nitration of Arachidonic Acid

Current Vascular Pharmacology, 2004
When a spontaneous autoxidation of arachidonic acid to prostaglandin-like products was first described almost 40 years ago, it was thought to be an artifact that interfered with the detection of enzymatically generated prostaglandins. It has now been generally accepted that the autoxidation of arachidonic acid occurs in vivo and leads to formation of ...
Candace D Poff, Michael Balazy
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Analysis of cytochrome P450 metabolites of arachidonic and linoleic acids by liquid chromatography-mass spectrometry with ion trap MS.

Analytical Biochemistry, 1998
We have used reversed phase-high performance liquid chromatography-mass spectrometry (RP-HPLC-MS) with an ion trap mass spectrometer to study the metabolism of arachidonic and linoleic acids by human recombinant cytochrome P450 (CYP) enzymes.
J. Bylund, Johanna Ericsson, E. Oliw
semanticscholar   +1 more source

Glucagon and plasma arachidonic acid

Metabolism, 1965
Abstract Previous work has shown the presence of a factor in the external pancreatic secretion of dogs distinct from the enzymes that affect plasma arachidonic acid. Removal of the exocrine factor by pancreatectomy or pancreatic duct ligation resulted in depression of arachidonic acid in all plasma lipid fractions which could not be corrected by ...
Raymond Caren, Lucille Corbo
openaire   +3 more sources

Psoriasis and the arachidonic acid cascade

Journal of Dermatological Science, 1999
Arachidonic acid (5.8,11,14-eicosatetraenoic acid C20:4, n-6) is released from the cell membrane by the action of phospholipases on membrane phospholipids. Metabolites of arachidonic acid, which are generically termed eicosanoids, including prostaglandins, thromboxane, leukotrienes and hydroxyeicosatetraenoic acids, have been implicated as mediators or
openaire   +2 more sources

Biologic Importance of Arachidonic Acid [PDF]

Archives of Internal Medicine, 1981
The most abundant prostaglandin precursor is arachidonic acid (or its precursor, linoleic acid). The isolation and identification of prostaglandin compounds in a particular tissue, knowledge of the biologic properties of these compounds, and the use of readily available inhibitors of the prostaglandin pathway by aspirin-like drugs constitute the main ...
openaire   +2 more sources

Vasoactivity of arachidonic acid epoxides

European Journal of Pharmacology, 1987
Arachidonic acid (AA) can be metabolized to epoxides and their corresponding diols via the cytochrome P450 epoxygenase pathway. We have compared the vascular activity of four synthetically prepared epoxyeicosatrienoic acids, i.e. 5,6-, 8,9-, 11,12- and 14,15-EET (2-20 microM) on the isolated perfused rat tail artery.
Mairead A. Carroll, John R. Falck, Jorge H. Capdevila, John C. McGiff, Michal L. Schwartzman   +4 more
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Regulation and metabolism of arachidonic acid

Clinical Reviews in Allergy & Immunology, 1999
The metabolism of AA reflects a carefully balanced series of biochemical pathways. The level of free arachidonate in a cells is controlled by de novo synthesis, dietary uptake, and transcellular metabolism. Lysophospholipids are key controlling substrates for a variety of acyl transferase and transacylase reactions, whose combined effect is to remodel ...
Michael C. Seeds, David A. Bass
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The Arachidonic Acid Cascade

1996
Arachidonic acid belongs to that relatively small group of chemical substances which were selected in the course of biological evolution to act as informational molecules. These signals are essential for the survival of free-living cells and for coordinating the complex needs of multicellular organisms: as adaptive demands and cell functions changed ...
openaire   +2 more sources