Results 31 to 40 of about 18,532 (196)

Inhibition of p38 Mitogen-Activated Protein Kinase Impairs Mayaro Virus Replication in Human Dermal Fibroblasts and HeLa Cells

Viruses, 2021
Mayaro virus (MAYV) hijacks the host’s cell machinery to effectively replicate. The mitogen-activated protein kinases (MAPKs) p38, JNK, and ERK1/2 have emerged as crucial cellular factors implicated in different stages of the viral cycle.
Madelaine Sugasti-Salazar, Yessica Y. Llamas-González, Dalkiria Campos, José González-Santamaría   +3 more
doaj   +1 more source

Circulation of Dirofilaria immitis and Dirofilaria repens in the Danube Delta Biosphere Reserve, Romania

Parasites & Vectors, 2018
Background Dirofilariosis is an emerging vector-borne parasitic disease in Europe. Monitoring of wild and domestic carnivores demonstrated circulation of Dirofilaria spp. in Romania in the past.
Alexandru Tomazatos, Daniel Cadar, Edina Török, Iulia Maranda, Cintia Horváth, Lujza Keresztes, Marina Spinu, Stephanie Jansen, Hanna Jöst, Jonas Schmidt-Chanasit, Egbert Tannich, Renke Lühken   +11 more
doaj   +1 more source

Trends of the Dengue Serotype-4 Circulation with Epidemiological, Phylogenetic, and Entomological Insights in Lao PDR between 2015 and 2019

Pathogens, 2020
Dengue outbreaks have regularly been recorded in Lao People’s Democratic Republic (PDR) since the first detection of the disease in 1979. In 2012, an integrated arbovirus surveillance network was set up in Lao PDR and an entomological surveillance has ...
Elodie Calvez, Virginie Pommelet, Somphavanh Somlor, Julien Pompon, Souksakhone Viengphouthong, Phaithong Bounmany, Thep Aksone Chindavong, Thonglakhone Xaybounsou, Phoyphaylinh Prasayasith, Sitsana Keosenhom, Paul T. Brey, Olivier Telle, Marc Choisy, Sébastien Marcombe, Marc Grandadam   +14 more
doaj   +1 more source

Unexpected high circulation of Plasmodium vivax in asymptomatic children from Kédougou, southeastern Senegal

Malaria Journal, 2017
Background Malaria in Senegal is due essentially to infections by Plasmodium falciparum and, to a lesser extent to Plasmodium malariae and Plasmodium ovale.
Makhtar Niang, Fode Diop, Oulimata Niang, Bacary D. Sadio, Abdourahmane Sow, Ousmane Faye, Mawlouth Diallo, Amadou A. Sall, Ronald Perraut, Aissatou Toure-Balde   +9 more
doaj   +1 more source

RNF138‐Mediated Ubiquitination and Degradation of NS5 Restricts Tick‐Borne Encephalitis Virus Infection

Advanced Science, EarlyView.
Host‐specific compatibility between RNF138‐like proteins and flavivirus NS5 determines NS5 stability. Mammalian RNF138 but not arthropod homologs recognizes and induces conserved NS5/RdRp K48‐linked ubiquitination and proteasomal degradation, thereby restricting viral replication. Ectopic RNF138 in mice attenuates TBEV‐induced pathogenesis. (Created in
Jialiang Sun, Weijing Yang, Hao Zhou, Shuai Li, Xin Jiang, Jianyang Gu, Wenyan Zhang   +6 more
wiley   +1 more source

Development and validation of a Vero cell DNA standard for residual DNA measurement suitable for quantitative PCR method

Frontiers in Microbiology
IntroductionThe fluorescence quantitative PCR method for the detection of Vero cell residual DNA in human rabies vaccine urgently needs a national standard for Vero cell DNA quantification.MethodsBriefly, the genomic DNA of Vero cells was extracted ...
Danhua Zhao, Yunpeng Wang, Xiaohong Wu, Leitai Shi, Jia Li, Yuhua Li, Shouchun Cao, Shouchun Cao   +7 more
doaj   +1 more source

Molecular Epidemiology of Bluetongue Virus Serotype 9 in the Mediterranean Region

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 2009
Resumen en inglès, ver archivo ...
K. Nomikou, S. Maan, N. S. Maan, P. P.C. Mertens   +3 more
doaj   +1 more source

Immune Modulatory Therapy for Severe Dengue Hemorrhagic Fever in a Patient With Mitochondrial Complex I Deficiency: A Case Report

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Dengue virus (DENV) poses a serious global health challenge, particularly in cases of dengue hemorrhagic fever (DHF). Patients with preexisting mitochondrial disorders may be at increased risk for complications due to the specific impact of DENV on mitochondrial‐dependent cellular processes and immune function.
Audra N. Iness, Ameya S. Walimbe, Emily R. Strouphauer, Michio Hirano, Alejandro D. Iglesias, Valentina Emmanuele, Caitlin C. Griffin, Sheldon L. Kaplan, William A. Gomes, Karen K. Moeller, Stephen F. Kralik, Fernando Scaglia   +11 more
wiley   +1 more source

Nationwide surveillance detects yellow fever and chikungunya viruses in multiple Aedes mosquito species in Nigeria

Parasites & Vectors
Background Since the reemergence of yellow fever in 2017, the Nigeria Centre for Disease Control (NCDC) has been coordinating responses to local outbreaks with the support of the World Health Organization (WHO).
Udoka C. Nwangwu, Harouna Soumare, Judith U. Oguzie, William E. Nwachukwu, Cosmas O. Onwude, Festus A. Dogunro, Mawlouth Diallo, Chukwuebuka K. Ezihe, Nneka O. Agashi, Emelda I. Eloy, Stephen O. Anokwu, Clementina C. Anioke, Linda C. Ikechukwu, Chukwuebuka M. Nwosu, Oscar N. Nwaogo, Ifeoma M. Ngwu, Rose N. Onyeanusi, Angela I. Okoronkwo, Francis U. Orizu, Monica O. Etiki, Esther N. Onuora, Peter C. Okeke, Okechukwu C. Chukwuekezie, Josephine C. Ochu, Anise N. Happi, Sulaiman S. Ibrahim, Adetifa Ifedayo, Chikwe Ihekweazu, Christian T. Happi   +28 more
doaj   +1 more source

RNA-Seq analysis of blood meal induced gene-expression changes in Aedes aegypti ovaries

BMC Genomics, 2021
Background Transmission of pathogens by vector mosquitoes is intrinsically linked with mosquito’s reproductive strategy because anautogenous mosquitoes require vertebrate blood to develop a batch of eggs.
Dilip K. Nag, Constentin Dieme, Pascal Lapierre, Erica Lasek-Nesselquist, Laura D. Kramer   +4 more
doaj   +1 more source