Results 71 to 80 of about 346,790 (222)

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

Deconstructing Ataxia with Oculomotor Apraxia: Toward a Gene‐Based Classification and a Reappraisal of the Oculomotor Phenotype

Movement Disorders Clinical Practice, EarlyView.
Luiz Eduardo Novis, Flávio Moura Rezende Filho, Anna Maria Gomes, Victor Rebelo Procaci, Orlando Graziani Povoas Barsottini, José Luiz Pedroso   +5 more
wiley   +1 more source

Crossing subfamily borders: Mechanosensitive TREK‐1 and alkaline‐activated TASK‐4 form heterodimers with unique functional and pharmacological properties

British Journal of Pharmacology, EarlyView.
Background and Purpose The tandem of two‐pore‐domain potassium (K2P) channels TREK‐1 and TASK‐4 are expressed in the heart and pancreatic beta‐cells. As TREK‐1 and TASK‐4 belong to distinct subfamilies with different functional hallmarks, heteromerization of these two channels was highly unexpected.
Sven Schütte, Florian Schick, Emilia De Martino, Hannah Schmitz, Katharina E. S. Zander, Franziska Holz, Patrick Sauer, Luise Mildeberger, Moritz Linder, Axel Loewe, Aytug K. Kiper, Silke Kauferstein, Martin K.‐H. Schäfer, Susanne Rinné, Niels Decher   +14 more
wiley   +1 more source

Global Effects of the Transcriptional Regulators ArcA and FNR in Anaerobically Grown Salmonella enterica sv. Typhimurium 14028s.

, 2008
EVANS, MATTHEW RICHARD. Global Effects of the Transcriptional Regulators ArcA and FNR in Anaerobically Grown Salmonella enterica sv. Typhimurium 14028s. (Under the direction of Dr. Hosni M.
Evans, Matthew Richard
core  

Additional file 2 of The effect of ArcA on the growth, motility, biofilm formation, and virulence of Plesiomonas shigelloides

, 2021
Additional file 2: Figure S2. Confirmation of the deletion of arcA in P. shigelloides. 1, DL2000 DNA marker (The bands shown in the electrophoretic gel are as follows: 2000 bp, 1000 bp, 750 bp, 500 bp, 250 bp and 100 bp); 2, PCR fragment of SX (800 bp ...
Xiaochen Wang (235611), Junxiang Yan (11521975), Ang Li (110963), Yuehua Li (337489), Boyang Cao (668880), Xueqian Guo (11521978), Fenxia Liu (11521981)   +6 more
core   +1 more source

A arca de Noé

Arquivo Maaravi: Revista Digital de Estudos Judaicos da UFMG, 2019
A arca de ...
Grzybowski, Adam, Goldman, Luis
openaire   +3 more sources

Eight Years of Citizen Science Reveal Taxonomic Confusion Patterns and Dynamic Participation in the Monitoring of Vespa velutina in Spain

Journal of Applied Entomology, EarlyView.
ABSTRACT The yellow‐legged hornet (Vespa velutina nigrithorax) is a successful invasive species in Europe, where its monitoring is partially reliant on citizen science (CS) initiatives. While CS is a powerful tool for early detection, taxonomic confusion and fluctuating participant engagement can limit its effectiveness.
Cayetano Herrera, Carlos Guerrero, Joan Amengual, Gabriel Arbona, Mar Leza   +4 more
wiley   +1 more source

Joseph Beuys’ Rediscovery of Man–Nature Relationship: A Pioneering Experience of Open Social Innovation

Journal of Open Innovation: Technology, Market and Complexity, 2018
The emerging paradigm of sustainability represents a challenging field in terms of new technologies, market regulations, and business models. Limits of both linear industrial development and consumerist way of living have been clearly identified since ...
Fabio Maria Montagnino
doaj   +1 more source

Social media, high‐frequency trading, and market making after‐hours – Evidence from presidential tweets

Journal of Financial Research, EarlyView.
Abstract I analyze differences between the core and extended trading sessions in the high‐frequency reaction of equity markets to potential news. Using presidential tweets as unanticipated, potentially market‐stirring events, I find that volatility increases and liquidity deteriorates within fractions of a second after a tweet.
Stefan Scharnowski
wiley   +1 more source

The Keystone‐Pathogen Hypothesis Updated: The Role of Porphyromonas gingivalis in Periodontitis

Journal of Periodontal Research, EarlyView.
Porphyromonas gingivalis orchestrates a coordinated manipulation of immune and inflammatory responses in periodontal tissues which leads to the generation of a dysbiotic, subgingival biofilm community, and progression of periodontitis. The type 9 secretion system, lipid A modification, and the formation of outer membrane vesicles are important ...
Mike A. Curtis, James A. Garnett, Richard P. Darveau   +2 more
wiley   +1 more source