Results 111 to 120 of about 1,586,071 (235)

Modulation of MCM Helicase activity [PDF]

, 2011
The minichromosome maintenance (MCM) proteins are essential for the initiation and progression of DNA replication. MCMs are believed to function as the replicative helicase in archaea and eukaryotes.
Satti, Rabab
core  

Investigation of the Relationship between the S1 Domain and Its Molecular Functions Derived from Studies of the Tertiary Structure

Molecules, 2019
S1 domain, a structural variant of one of the “oldest” OB-folds (oligonucleotide/oligosaccharide-binding fold), is widespread in various proteins in three domains of life: Bacteria, Eukaryotes, and Archaea. In this study, it was shown that S1
Evgenia I. Deryusheva, Andrey V. Machulin, Maxim A. Matyunin, Oxana V. Galzitskaya   +3 more
doaj   +1 more source

A Single‐Cell Transcriptomic Atlas of the Ovine Rumen Microbiome Characterizes Lineage‐Specific Metabolic Shifts Associated with Host Heat Tolerance

Advanced Science, Volume 13, Issue 51, 14 September 2026.
An optimized single‐cell transcriptomic framework profiles over 60 000 cells to map the ovine rumen microbiome, partitioning the ecosystem into seven cross‐species functional clusters. In heat‐resistant hosts, a lineage‐specific metabolic shift in Anaerovibrio lipolyticus toward a highly glycolytic phenotype contributes to a “nutritional sparing ...
Sanbao Zhang, Qinyang Jiang, Junjie Ma, Jianwei Zou, Fan Wang, Feifei Lv, Yanna Huang, Yongcheng Wang, Ziye Xu   +8 more
wiley   +1 more source

The Oral Microbiome of King Richard III of England

American Journal of Biological Anthropology, Volume 191, Issue 1, September 2026.
ABSTRACT Objectives Metagenomic investigations of ancient dental calculus provide insights into oral health, disease, and diet. Here, we analyze the dental calculus metagenome of King Richard III of England (1452–1485). Materials and Methods Dental calculus DNA was extracted from three teeth of King Richard III and shotgun sequenced to a depth of ...
Irina M. Velsko, Alexander Hübner, Zandra Fagernäs, James A. Fellows Yates, Allison E. Mann, Courtney A. Hofman, Andrew T. Ozga, Cecil M. Lewis Jr., Camilla Speller, Sarah Fiddyment, Michael Francken, Joachim Wahl, Johannes Krause, Anita Radini, Turi King, Christina Warinner   +15 more
wiley   +1 more source

Fusion/fission protein family identification in Archaea

mSystems
The majority of newly discovered archaeal lineages remain without a cultivated representative, but scarce experimental data from the cultivated organisms show that they harbor distinct functional repertoires.
Anastasiia Padalko, Govind Nair, Filipa L. Sousa   +2 more
doaj   +1 more source

Lifestyle Impacts the Oral Microbiome of Classical and Post‐Classical Societies in Italy

American Journal of Biological Anthropology, Volume 191, Issue 1, September 2026.
ABSTRACT Objectives The fall of the Roman Empire (476 CE) profoundly affected the lives of its peoples due to the political, administrative, and territorial changes that occurred. The majority of written records of the time focus on the social élite, leaving larger parts of the population understudied.
Martina Farese, Markella Moraitou, Chenyu Jin, Adrian Forsythe, Ileana Micarelli, Tom van der Valk, Giorgio Manzi, Laura Parducci, Mary Anne Tafuri, Katerina Guschanski   +9 more
wiley   +1 more source

The Prevalence of STIV c92-Like Proteins in Acidic Thermal Environments

Advances in Virology, 2011
A new type of viral-induced lysis system has recently been discovered for two unrelated archaeal viruses, STIV and SIRV2. Prior to the lysis of the infected host cell, unique pyramid-like lysis structures are formed on the cell surface by the protrusion ...
Jamie C. Snyder, Benjamin Bolduc, Mary M. Bateson, Mark J. Young   +3 more
doaj   +1 more source

Architectures of archaeal GINS complexes, essential DNA replication initiation factors

BMC Biology, 2011
Background In the early stage of eukaryotic DNA replication, the template DNA is unwound by the MCM helicase, which is activated by forming a complex with the Cdc45 and GINS proteins.
Saito Mihoko, Nagasawa Naoko, Mayanagi Kouta, Shirai Tsuyoshi, Ogino Hiromi, Fujino Seiji, Ishino Sonoko, Oyama Takuji, Ishino Yoshizumi, Morikawa Kosuke   +9 more
doaj   +1 more source

Monoallelic POLR3A Variants Cause Early‐Onset Peripheral Neuropathy

Annals of Neurology, Volume 100, Issue 3, Page 655-671, September 2026.
Objective Biallelic variants in genes encoding the RNA polymerase III complex (Pol III) cause a spectrum of neurological disorders primarily affecting the central nervous system. Monoallelic variants have been reported in the POLR3B subunit only, associated with neurodevelopmental disorder, epilepsy, and peripheral neuropathy.
Luiza L. P. Ramos, Jevin M. Parmar, Robin Wijngaard, Bianca R. Grosz, Tamas Lazar, Ligia Mateiu, Steve Vucic, Kishore R. Kumar, Dennis Yeow, Laura I. Rudaks, Lonneke de Boer, Annemarie de Vreugd, David A. Koolen, Thatjana Gardeitchik, Anita Cairns, Krishnan Iyengar, Fernando Kok, Fernanda Barbosa Figueiredo, Alzira Alves de Siqueira Carvalho, Luiz S. Mageste Barbosa, Rodrigo Rezende Arantes, Tyler Rehbein, Jordan E. Bontrager, Elizabeth P. Wood, Janet E. Sowden, Gavin Monahan, Meutia Kumaheri, Ivy Cuijt, Melina Ellis, Gonzalo Perez‐Siles, Elyshia McNamara, Ronald van Beek, Celine B. Meijers, Ivaylo Tournev, Stephan Zuchner, Shoshana J. Wodak, Clara D. M. van Karnebeek, Nigel Laing, Liana N. Semcesen, David A. Stroud, David N. Herrmann, Velina Guergueltcheva, Marina L. Kennerson, Machteld M. Oud, Gianina Ravenscroft, Ayse Candayan, Albena Jordanova   +46 more
wiley   +1 more source

Bioinformatic Analysis Reveals Archaeal tRNATyr and tRNATrp Identities in Bacteria

Life, 2017
The tRNA identity elements for some amino acids are distinct between the bacterial and archaeal domains. Searching in recent genomic and metagenomic sequence data, we found some candidate phyla radiation (CPR) bacteria with archaeal tRNA identity for Tyr-
Takahito Mukai, Noah M. Reynolds, Ana Crnković, Dieter Söll   +3 more
doaj   +1 more source