Results 11 to 20 of about 2,147 (170)

Central terminals of primary afferents coordinate the spontaneous activity of dorsal horn neurons. [PDF]

J Physiol
Central terminals of primary afferents and dorsal horn neurons usually exhibit spontaneous activity, the two phenomena being interrelated. Spontaneous activity may constitute a system for adjusting the level of excitation of spinal circuits and the ...
Lucas-Romero J, Lopez-Garcia JA, Rivera-Arconada I.   +2 more
europepmc   +4 more sources

Photoactivation of Cell-Free Expressed Archaerhodopsin-3 in a Model Cell Membrane. [PDF]

Int J Mol Sci, 2021
Transmembrane receptor proteins are located in the plasma membranes of biological cells where they exert important functions. Archaerhodopsin (Arch) proteins belong to a class of transmembrane receptor proteins called photoreceptors that react to light.
Khangholi N, Finkler M, Seemann R, Ott A, Fleury JB.   +4 more
europepmc   +3 more sources

Photocycle Dynamics of the Archaerhodopsin 3 Based Fluorescent Voltage Sensor QuasAr1 [PDF]

, 2019
The retinal photocycle dynamics of the fluorescent voltage sensor QuasAr1 (Archaerhodopsin 3 P60S-T80S-D95H-D106H-F161V mutant from Halorubrum sodomense) in pH 8 Tris buffer was studied.
Hegemann, Peter, Penzkofer, Alfons, Silapetere, Arita   +2 more
core   +4 more sources

Enhanced Archaerhodopsin Fluorescent Protein Voltage Indicators. [PDF]

PLoS ONE, 2013
A longstanding goal in neuroscience has been to develop techniques for imaging the voltage dynamics of genetically defined subsets of neurons. Optical sensors of transmembrane voltage would enhance studies of neural activity in contexts ranging from ...
Yiyang Gong, Jin Zhong Li, Mark J Schnitzer   +2 more
doaj   +3 more sources

Microbial light-activatable proton pumps as neuronal inhibitors to functionally dissect neuronal networks in C. elegans. [PDF]

PLoS ONE, 2012
Essentially any behavior in simple and complex animals depends on neuronal network function. Currently, the best-defined system to study neuronal circuits is the nematode Caenorhabditis elegans, as the connectivity of its 302 neurons is exactly known ...
Steven J Husson, Jana F Liewald, Christian Schultheis, Jeffrey N Stirman, Hang Lu, Alexander Gottschalk   +5 more
doaj   +5 more sources

QuasAr Odyssey: the origin of fluorescence and its voltage sensitivity in microbial rhodopsins. [PDF]

Nat Commun, 2022
Rhodopsins had long been considered non-fluorescent until a peculiar voltage-sensitive fluorescence was reported for archaerhodopsin-3 (Arch3) derivatives.
Silapetere A, Hwang S, Hontani Y, Fernandez Lahore RG, Balke J, Escobar FV, Tros M, Konold PE, Matis R, Croce R, Walla PJ, Hildebrandt P, Alexiev U, Kennis JTM, Sun H, Utesch T, Hegemann P.   +16 more
europepmc   +3 more sources

Optogenetic modulation of peripheral nociceptive neurons with biocompatible optoelectronic implants [PDF]

Bioengineering & Translational Medicine
Hyperexcitability of peripheral sensory neurons plays a critical role in the development and maintenance of chronic pain. Pharmacological analgesics used in clinics reduce neuronal activity. They often come with non‐negligible side effects.
Paul Chu Sin Chung, Valentina Paggi, Marie Pertin, Guylène Kirschmann, Elena A. Konnova, Frédéric Michoud, Ivan Furfaro, Bernard L. Schneider, Stéphanie P. Lacour, Isabelle Decosterd   +9 more
doaj   +2 more sources

Bacteriorhodopsin of purple membrane reverses anisotropy outside the pH range of proton pumping based on logic gate realization [PDF]

Scientific Reports
The bacteriorhodopsin of purple membrane is the first discovered light-sensing protein among ion transporting microbial rhodopsins, some of which (e.g.
Hamdy I. A. Mostafa, Abdo A. Elfiki
doaj   +2 more sources

A versatile approach to high-density microcrystals in lipidic cubic phase for room-temperature serial crystallography. [PDF]

J Appl Crystallogr, 2023
A versatile approach for the preparation of high‐density membrane protein microcrystals in lipidic cubic phase for serial crystallography is described.Serial crystallography has emerged as an important tool for structural studies of integral membrane proteins.
Birch J, Kwan TOC, Judge PJ, Axford D, Aller P, Butryn A, Reis RI, Bada Juarez JF, Vinals J, Owen RL, Nango E, Tanaka R, Tono K, Joti Y, Tanaka T, Owada S, Sugahara M, Iwata S, Orville AM, Watts A, Moraes I.   +20 more
europepmc   +2 more sources

Mechanistic insight into the initiation of spreading depolarizations: Is it really all about potassium? [PDF]

J Physiol
The Journal of Physiology, Volume 603, Issue 11, Page 3269-3273, 1 June 2025.
Ricks R, MacKenzie-Gray Scott C, Trevelyan AJ, Parrish RR.   +3 more
europepmc   +2 more sources