Correction: Silencing of Cholinergic Basal Forebrain Neurons Using Archaerhodopsin Prolongs Slow-Wave Sleep in Mice. [PDF]
PLoS ONE, 2015 There are errors in the Funding section. The correct funding information is as follows: open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any ...
PLOS ONE Staff
doaj +5 more sources
Structures of the archaerhodopsin-3 transporter reveal that disordering of internal water networks underpins receptor sensitization [PDF]
Nature Communications, 2021 Archaerhodopsin-3 (AR3) mutants are commonly used in optogenetics for neuron silencing and membrane voltage sensing. High-resolution crystal structures show that desensitization of the AR3 photoreceptor occurs when internal hydrogen-bonded water networks
Juan F. Bada Juarez +14 more
doaj +5 more sources
Optogenetic ion pumps differ with respect to the secondary pattern of K+ redistribution [PDF]
Physiological Reports, 2023 We recently reported that strong activation of the optogenetic chloride pump, halorhodopsin leads to a secondary redistribution of K+ ions into the cell, through tonically open, “leak” K+ channels.
R. Ryley Parrish +3 more
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Frontiers in Molecular Biosciences, 2021 Rhodopsins act as photoreceptors with their chromophore retinal (vitamin-A aldehyde) and they regulate light-dependent biological functions. Archaerhodopsin-3 (AR3) is an outward proton pump that has been widely utilized as a tool for optogenetics, a ...
Taichi Tsuneishi +7 more
doaj +3 more sources
Photocycle dynamics of the Archaerhodopsin 3 based fluorescent voltage sensor Archon2
Journal of Photochemistry and Photobiology B: Biology, 2021 The retinal photocycle dynamics of the fluorescent voltage sensor Archon2 in pH 8 Tris buffer was studied. Archon2 is a mutant of Archaerhodopsin 3 (Arch) from Halorubrum sodomense obtained by a robotic multidimensional directed evolution approach (Archon2 = Arch T56P-P60S-T80P-D95H-T99S-T116I-F161V-T183I-L197I-A225C). The samples were photo-excited to
А. Penzkofer +2 more
semanticscholar +4 more sources
Photocycle Dynamics of the Archaerhodopsin 3 Based Fluorescent Voltage Sensor QuasAr1 [PDF]
International Journal of Molecular Sciences, 2019 The retinal photocycle dynamics of the fluorescent voltage sensor QuasAr1 (Archaerhodopsin 3 P60S-T80S-D95H-D106H-F161V mutant from Halorubrum sodomense) in pH 8 Tris buffer was studied.
А. Penzkofer +2 more
semanticscholar +6 more sources
Archaerhodopsin Voltage Imaging: Synaptic Calcium and BK Channels Stabilize Action Potential Repolarization at theDrosophilaNeuromuscular Junction [PDF]
The Journal of Neuroscience, 2014 The strength and dynamics of synaptic transmission are determined, in part, by the presynaptic action potential (AP) waveform at the nerve terminal. The ion channels that shape the synaptic AP waveform remain essentially unknown for all but a few large ...
Kevin Ford, Graeme W. Davis
semanticscholar +6 more sources
Two-photon photoactivated voltage imaging in tissue with an Archaerhodopsin-derived reporter [PDF]
Science Advances, 2017 A photoactivated fluorescent voltage sensor protein combines high sensitivity and optical sectioning in tissue. Photoactivated genetically encoded voltage indicators (GEVIs) have the potential to enable optically sectioned voltage imaging at the ...
Miao‐Ping Chien +5 more
semanticscholar +5 more sources
Constitutive Activity of the Dual-Chromophore Photoreceptor Archaerhodopsin 4 [PDF]
Biophysical Journal, 2020 Xiaoyan Ding +8 more
semanticscholar +3 more sources
Near-IR Resonance Raman Spectroscopy of Archaerhodopsin 3: Effects of Transmembrane Potential [PDF]
The Journal of Physical Chemistry B, 2012 Archaerhodopsin 3 (AR3) is a light driven proton pump from Halorubrum sodomense that has been used as a genetically targetable neuronal silencer and an effective fluorescent sensor of transmembrane potential. Unlike the more extensively studied bacteriorhodopsin (BR) from Halobacterium salinarum, AR3 readily incorporates into the plasma membrane of ...
Erica C. Saint Clair +5 more
semanticscholar +5 more sources