Results 31 to 40 of about 2,147 (170)
Advanced near‐infrared light approaches for neuroimaging and neuromodulation
BMEMat, Volume 1, Issue 2, June 2023., 2023 Near‐infrared (NIR) (700–1700 nm) light‐based techniques offer the possibility to monitor and modulate brain functions and diseases in vivo with exceptional spatiotemporal precision. In this review, we provide an up‐to‐date overview of the recent NIR neuroimaging and neuromodulation approaches to monitor and modulate critical neural ions, membrane ...
Hongqiang Yin +8 more
wiley +1 more source
eLife, 2017 To study cerebellar activity during learning, we made whole-cell recordings from larval zebrafish Purkinje cells while monitoring fictive swimming during associative conditioning.
Thomas C Harmon +3 more
doaj +1 more source
Transient Suppression of Dbx1 PreBötzinger Interneurons Disrupts Breathing in Adult Mice. [PDF]
PLoS ONE, 2016 Interneurons derived from Dbx1-expressing precursors located in the brainstem preBötzinger complex (preBötC) putatively form the core oscillator for inspiratory breathing movements.
Nikolas C Vann +4 more
doaj +1 more source
Glia, Volume 71, Issue 6, Page 1383-1401, June 2023., 2023 Main Points Astrocytes, microglia, and oligodendrocyte lineage cells remodel the structure and function of synapses in the brain. Aberrant synaptic communications between neurons and glia contribute to neural pathologies. Abstract The mammalian brain is a complex organ comprising neurons, glia, and more than 1 × 1014 synapses.
Yao Liu +7 more
wiley +1 more source
Recent advances in engineering microbial rhodopsins for optogenetics [PDF]
, 2015 Protein engineering of microbial rhodopsins has been successful in generating variants with improved properties for applications in optogenetics.
Arnold, Frances H. +2 more
core +1 more source
Surgical Procedure for Implantation of Opto‐Array in Nonhuman Primates
Current Protocols, Volume 3, Issue 3, March 2023., 2023 Abstract Optogenetics allows precise temporal control of neuronal activity in the brain. Engineered viral vectors are routinely used to transduce neurons with light‐sensitive opsins. However, reliable virus injection and light delivery in animals with large brains, such as nonhuman primates, has proven challenging.
Reza Azadi +3 more
wiley +1 more source
Active avoidance requires inhibitory signaling in the rodent prelimbic prefrontal cortex
eLife, 2018 Much is known about the neural circuits of conditioned fear and its relevance to understanding anxiety disorders, but less is known about other anxiety-related behaviors such as active avoidance.
Maria M Diehl +6 more
doaj +1 more source
Directed evolution of a far-red fluorescent rhodopsin [PDF]
, 2014 Microbial rhodopsins are a diverse group of photoactive transmembrane proteins found in all three domains of life. A member of this protein family, Archaerhodopsin-3 (Arch) of halobacterium Halorubrum sodomense, was recently shown to function as a ...
Arnold, Frances H. +10 more
core +2 more sources
Optogenetic Hyperpolarization of Cardiomyocytes Terminates Ventricular Arrhythmia
Frontiers in Physiology, 2019 Cardiac defibrillation to terminate lethal ventricular arrhythmia (VA) is currently performed by applying high energy electrical shocks. In cardiac tissue, electrical shocks induce simultaneously de- and hyperpolarized areas and only depolarized areas ...
Maximilian Funken +7 more
doaj +1 more source
Characterization of Channelrhodopsin and Archaerhodopsin in Cholinergic Neurons of Cre-Lox Transgenic Mice. [PDF]
PLoS ONE, 2016 The study of cholinergic signaling in the mammalian CNS has been greatly facilitated by the advent of mouse lines that permit the expression of reporter proteins, such as opsins, in cholinergic neurons. However, the expression of opsins could potentially
Tristan Hedrick +7 more
doaj +1 more source