Results 41 to 50 of about 2,147 (170)

The role of higher-order thalamus during learning and correct performance in goal-directed behavior

eLife, 2022
The thalamus is a gateway to the cortex. Cortical encoding of complex behavior can therefore only be understood by considering the thalamic processing of sensory and internally generated information.
Danilo La Terra, Ann-Sofie Bjerre, Marius Rosier, Rei Masuda, Tomás J Ryan, Lucy M Palmer   +5 more
doaj   +1 more source

Bright and Fast Multicoloured Voltage Reporters via Electrochromic FRET [PDF]

, 2015
Genetically encoded fluorescent reporters of membrane potential promise to reveal aspects of neural function not detectable by other means. We present a palette of multicoloured brightly fluorescent genetically encoded voltage indicators with ...
Brinks, Daan, Campbell, Robert E., Cohen, Adam Ezra, Douglass, Adam D., Harrison, D. Jed, Hochbaum, Daniel Ron, Werley, Christopher A, Zhao, Yongxin, Zou, Peng   +8 more
core   +1 more source

Motoneurons regulate the central pattern generator during drug-induced locomotor-like activity in the neonatal mouse

eLife, 2017
Motoneurons are traditionally viewed as the output of the spinal cord that do not influence locomotor rhythmogenesis. We assessed the role of motoneuron firing during ongoing locomotor-like activity in neonatal mice expressing archaerhopsin-3 (Arch ...
Melanie Falgairolle, Joshua G Puhl, Avinash Pujala, Wenfang Liu, Michael J O’Donovan   +4 more
doaj   +1 more source

Divergent projections of the prelimbic cortex bidirectionally regulate active avoidance

eLife, 2020
The prefrontal cortex (PFC) integrates incoming information to guide our actions. When motivation for food-seeking competes with avoidance of danger, the PFC likely plays a role in selecting the optimal choice. In platform-mediated active avoidance, rats
Maria M Diehl, Jorge M Iravedra-Garcia, Jonathan Morán-Sierra, Gabriel Rojas-Bowe, Fabiola N Gonzalez-Diaz, Viviana P Valentín-Valentín, Gregory J Quirk   +6 more
doaj   +1 more source

Optogenetics and deep brain stimulation neurotechnologies [PDF]

, 2015
Brain neural network is composed of densely packed, intricately wired neurons whose activity patterns ultimately give rise to every behavior, thought, or emotion that we experience. Over the past decade, a novel neurotechnique, optogenetics that combines
A Berndt, A Berndt, A Priori, AA Kuhn, AA Kuhn, AS Chuong, B Sauer, B Wingeier, BY Chow, BY Chow, C Bamann, D Luo, D Oesterhelt, D Oesterhelt, D Williams, ES Boyden, EY Uc, F Zhang, F Zhang, G Foffani, G Miesenbock, G Nagel, J Cavanaugh, J Mobley, J Volkmann, J Wells, J Wietek, JG Bernstein, JG Bernstein, JG Bernstein, JL Spudich, JL Spudich, JO Dostrovsky, JZ Tsien, L Bekar, L Madisen, LA Gunaydin, M Weinberger, M Weinberger, MC Rodriguez-Oroz, MJ Lehmkuhle, ML Welter, MM Doroudchi, O Yizhar, P Brown, P Silberstein, R Levy, R Levy, R Levy, R Waehler, S Zhao, TW Chen, VC Anderson, X Han, X Han, X Han, X Han, X Han, X Liu   +58 more
core   +2 more sources

A history of optogenetics: the development of tools for controlling brain circuits with light [PDF]

, 2011
Understanding how different kinds of neuron in the brain work together to implement sensations, feelings, thoughts, and movements, and how deficits in specific kinds of neuron result in brain diseases, has long been a priority in basic and clinical ...
Boyden, Edward Stuart
core   +2 more sources

Specificity, Versatility, and Continual Development: The Power of Optogenetics for Epilepsy Research

Frontiers in Cellular Neuroscience, 2018
Optogenetics is a powerful and rapidly expanding set of techniques that use genetically encoded light sensitive proteins such as opsins. Through the selective expression of these exogenous light-sensitive proteins, researchers gain the ability to ...
Zoé Christenson Wick, Esther Krook-Magnuson   +1 more
doaj   +1 more source

Directed Evolution of a Bright Near-Infrared Fluorescent Rhodopsin Using a Synthetic Chromophore [PDF]

, 2017
By engineering a microbial rhodopsin, Archaerhodopsin-3 (Arch), to bind a synthetic chromophore, merocyanine retinal, in place of the natural chromophore all-trans-retinal (ATR), we generated a protein with exceptionally bright and unprecedentedly red ...
Arnold, Frances H., Bedbrook, Claire N., Cahn, Jackson K. B., Cai, Long, Cho, Inha, Dodani, Sheel C., Gradinaru, Viviana, Herwig, Lukas, Lignell, Antti, Renata, Hans, Rice, Austin J., Zhang, Ruijie K.   +11 more
core   +2 more sources

Monod-Wyman-Changeux Analysis of Ligand-Gated Ion Channel Mutants [PDF]

, 2017
We present a framework for computing the gating properties of ligand-gated ion channel mutants using the Monod-Wyman-Changeux (MWC) model of allostery. We derive simple analytic formulas for key functional properties such as the leakiness, dynamic range,
Einav, Tal, Phillips, Rob
core   +4 more sources

Exploring the Retinal Binding Cavity of Archaerhodopsin-3 by Replacing the Retinal Chromophore With a Dimethyl Phenylated Derivative

Frontiers in Molecular Biosciences, 2021
Rhodopsins act as photoreceptors with their chromophore retinal (vitamin-A aldehyde) and they regulate light-dependent biological functions. Archaerhodopsin-3 (AR3) is an outward proton pump that has been widely utilized as a tool for optogenetics, a ...
Taichi Tsuneishi, Masataka Takahashi, Masaki Tsujimura, Keiichi Kojima, Hiroshi Ishikita, Hiroshi Ishikita, Yasuo Takeuchi, Yuki Sudo   +7 more
doaj   +1 more source