Results 51 to 60 of about 2,147 (170)
Off-Target Influences of Arch-Mediated Axon Terminal Inhibition on Network Activity and Behavior
Frontiers in Neural Circuits, 2020 Archaerhodopsin (ArchT)-mediated photoinhibition of axon terminals is commonly used to test the involvement of specific long-range neural projections in behavior.
Christopher K. Lafferty +3 more
doaj +1 more source
Differential regulation of bladder pain and voiding function by sensory afferent populations revealed by selective optogenetic activation [PDF]
, 2010 Bladder-innervating primary sensory neurons mediate reflex-driven bladder function under normal conditions, and contribute to debilitating bladder pain and/or overactivity in pathological states. The goal of this study was to examine the respective roles
DeBerry, Jennifer J +7 more
core +4 more sources
Scientific Reports, 2023 Cataplexy is one of the symptoms of type 1 narcolepsy, characterized by a sudden loss of muscle tone. It can be seen as a behavioral index of salience, predominantly positive emotion, since it is triggered by laughter in humans and palatable foods in ...
Shigetaka Kawashima +4 more
doaj +1 more source
Synaptic Plasticity and Memory: New Insights from Hippocampal Left-Right Asymmetries. [PDF]
, 2014 All synapses are not the same. They differ in their morphology, molecular constituents, and malleability. A striking left-right asymmetry in the distribution of different types of synapse was recently uncovered at the CA3-CA1 projection in the mouse ...
El-Gaby, Mohamady +2 more
core +2 more sources
Cl-out is a novel cooperative optogenetic tool for extruding chloride from neurons
Nature Communications, 2016 Chloride regulation is important for setting GABAergic reversal potential, though tools to manipulate chloride levels are limited. Here, the authors combine Archaerhodopsin with a chloride channel opsin to generate an optogenetic chloride extrusion ...
Hannah Alfonsa +3 more
doaj +1 more source
Optical silencing of C. elegans cells with arch proton pump. [PDF]
PLoS ONE, 2012 BACKGROUND: Optogenetic techniques using light-driven ion channels or ion pumps for controlling excitable cells have greatly facilitated the investigation of nervous systems in vivo. A model organism, C.
Ayako Okazaki, Yuki Sudo, Shin Takagi
doaj +1 more source
Optogenetics: Molecular and Optical Tools for Controlling Life with Light [PDF]
, 2013 Optogenetic tools are genetically-encoded reagents that, when targeted to specific brain cells, enable their activity to be controlled by light. These tools are having broad impact on science, and may serve clinical roles as well.
Aravanis +31 more
core +1 more source
Frontiers in Physiology, 2014 The cardiac action potential (AP) and the consequent cytosolic Ca2+ transient are key indicators of cardiac function. Natural developmental processes, as well as many drugs and pathologies change the waveform, propagation, or variability (between cells ...
Jennifer H Hou +4 more
doaj +1 more source
Frontiers in Behavioral Neuroscience, 2020 Pain is comprised of both sensory and affective components. The anterior cingulate cortex (ACC) is a key brain region involved in the emotional processing of pain.
Sarah Jarrin +13 more
doaj +1 more source
Role of Prelimbic GABAergic Circuits in Sensory and Emotional Aspects of Neuropathic Pain
Cell Reports, 2015 Noxious stimuli are detected by peripheral nociceptors and then transmitted to higher CNS centers, where they are perceived as an unpleasant sensation.
Zizhen Zhang +5 more
doaj +1 more source