Results 51 to 60 of about 1,653 (173)

Screening fluorescent voltage indicators with spontaneously spiking HEK cells. [PDF]

PLoS ONE, 2013
Development of improved fluorescent voltage indicators is a key challenge in neuroscience, but progress has been hampered by the low throughput of patch-clamp characterization.
Jeehae Park, Christopher A Werley, Veena Venkatachalam, Joel M Kralj, Sulayman D Dib-Hajj, Stephen G Waxman, Adam E Cohen   +6 more
doaj   +1 more source

Glial modulation of the parallel memory formation

Glia, Volume 71, Issue 10, Page 2401-2417, October 2023., 2023
Main Points Short and long‐term memory are formed in parallel. Genetic or optogenetic manipulation of glial activity specifically modulated the online learning during the training period. Offline learning develops irrespective of online learning achievement.
Teppei Kanaya, Ryo Ito, Yosuke M. Morizawa, Daichi Sasaki, Hiroki Yamao, Hiroshi Ishikane, Yuichi Hiraoka, Kohichi Tanaka, Ko Matsui   +8 more
wiley   +1 more source

A voltage-dependent fluorescent indicator for optogenetic applications, archaerhodopsin-3: Structure and optical properties from in silico modeling [version 2; referees: 1 approved, 2 approved with reservations]

F1000Research, 2017
It was demonstrated in recent studies that some rhodopsins can be used in optogenetics as fluorescent indicators of membrane voltage. One of the promising candidates for these applications is archaerhodopsin-3.
Dmitrii M. Nikolaev, Anton Emelyanov, Vitaly M. Boitsov, Maxim S Panov, Mikhail N. Ryazantsev   +4 more
doaj   +1 more source

Distinct responses of Purkinje neurons and roles of simple spikes during associative motor learning in larval zebrafish

eLife, 2017
To study cerebellar activity during learning, we made whole-cell recordings from larval zebrafish Purkinje cells while monitoring fictive swimming during associative conditioning.
Thomas C Harmon, Uri Magaram, David L McLean, Indira M Raman   +3 more
doaj   +1 more source

Transient Suppression of Dbx1 PreBötzinger Interneurons Disrupts Breathing in Adult Mice. [PDF]

PLoS ONE, 2016
Interneurons derived from Dbx1-expressing precursors located in the brainstem preBötzinger complex (preBötC) putatively form the core oscillator for inspiratory breathing movements.
Nikolas C Vann, Francis D Pham, John A Hayes, Andrew Kottick, Christopher A Del Negro   +4 more
doaj   +1 more source

Advanced near‐infrared light approaches for neuroimaging and neuromodulation

BMEMat, Volume 1, Issue 2, June 2023., 2023
Near‐infrared (NIR) (700–1700 nm) light‐based techniques offer the possibility to monitor and modulate brain functions and diseases in vivo with exceptional spatiotemporal precision. In this review, we provide an up‐to‐date overview of the recent NIR neuroimaging and neuromodulation approaches to monitor and modulate critical neural ions, membrane ...
Hongqiang Yin, Wuqiao Jiang, Yongyang Liu, Dongyang Zhang, Feng Wu, Yejun Zhang, Chunyan Li, Guangcun Chen, Qiangbin Wang   +8 more
wiley   +1 more source

Motoneurons regulate the central pattern generator during drug-induced locomotor-like activity in the neonatal mouse

eLife, 2017
Motoneurons are traditionally viewed as the output of the spinal cord that do not influence locomotor rhythmogenesis. We assessed the role of motoneuron firing during ongoing locomotor-like activity in neonatal mice expressing archaerhopsin-3 (Arch ...
Melanie Falgairolle, Joshua G Puhl, Avinash Pujala, Wenfang Liu, Michael J O’Donovan   +4 more
doaj   +1 more source

Active avoidance requires inhibitory signaling in the rodent prelimbic prefrontal cortex

eLife, 2018
Much is known about the neural circuits of conditioned fear and its relevance to understanding anxiety disorders, but less is known about other anxiety-related behaviors such as active avoidance.
Maria M Diehl, Christian Bravo-Rivera, Jose Rodriguez-Romaguera, Pablo A Pagan-Rivera, Anthony Burgos-Robles, Ciorana Roman-Ortiz, Gregory J Quirk   +6 more
doaj   +1 more source

Astrocytic determinant of the fate of long-term memory. [PDF]

Glia
Main Points Opposing astrocyte manipulations cause fear‐like states or reduce fear. Astrocytes, at the moment of an experience, determine the long‐term memory fate. Astro‐ChR2 suppresses memory consolidation, while Astro‐ArchT inhibits remote memory decay.
Yamao H, Matsui K.
europepmc   +2 more sources

Optogenetic Hyperpolarization of Cardiomyocytes Terminates Ventricular Arrhythmia

Frontiers in Physiology, 2019
Cardiac defibrillation to terminate lethal ventricular arrhythmia (VA) is currently performed by applying high energy electrical shocks. In cardiac tissue, electrical shocks induce simultaneously de- and hyperpolarized areas and only depolarized areas ...
Maximilian Funken, Maximilian Funken, Daniela Malan, Philipp Sasse, Tobias Bruegmann, Tobias Bruegmann, Tobias Bruegmann, Tobias Bruegmann   +7 more
doaj   +1 more source