Results 61 to 70 of about 1,653 (173)
Divergent projections of the prelimbic cortex bidirectionally regulate active avoidance
eLife, 2020 The prefrontal cortex (PFC) integrates incoming information to guide our actions. When motivation for food-seeking competes with avoidance of danger, the PFC likely plays a role in selecting the optimal choice. In platform-mediated active avoidance, rats
Maria M Diehl +6 more
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The role of higher-order thalamus during learning and correct performance in goal-directed behavior
eLife, 2022 The thalamus is a gateway to the cortex. Cortical encoding of complex behavior can therefore only be understood by considering the thalamic processing of sensory and internally generated information.
Danilo La Terra +5 more
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Frontiers in Systems Neuroscience, 2011 Technologies for silencing the electrical activity of genetically-targeted neurons in the brain are important for assessing the contribution of specific cell types and pathways towards behaviors and pathologies.
Xue eHan +10 more
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Specificity, Versatility, and Continual Development: The Power of Optogenetics for Epilepsy Research
Frontiers in Cellular Neuroscience, 2018 Optogenetics is a powerful and rapidly expanding set of techniques that use genetically encoded light sensitive proteins such as opsins. Through the selective expression of these exogenous light-sensitive proteins, researchers gain the ability to ...
Zoé Christenson Wick +1 more
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Off-Target Influences of Arch-Mediated Axon Terminal Inhibition on Network Activity and Behavior
Frontiers in Neural Circuits, 2020 Archaerhodopsin (ArchT)-mediated photoinhibition of axon terminals is commonly used to test the involvement of specific long-range neural projections in behavior.
Christopher K. Lafferty +3 more
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Scientific Reports, 2023 Cataplexy is one of the symptoms of type 1 narcolepsy, characterized by a sudden loss of muscle tone. It can be seen as a behavioral index of salience, predominantly positive emotion, since it is triggered by laughter in humans and palatable foods in ...
Shigetaka Kawashima +4 more
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Journal of Neuroscience, 2019 Narcolepsy, characterized by excessive daytime sleepiness, is associated with dysfunction of the hypothalamic hypocretin/orexin (Hcrt) system, either due to extensive loss of Hcrt cells (Type 1, NT1) or hypothesized Hcrt signaling impairment (Type 2, NT2)
Rhîannan H. Williams +5 more
semanticscholar +1 more source
Cl-out is a novel cooperative optogenetic tool for extruding chloride from neurons
Nature Communications, 2016 Chloride regulation is important for setting GABAergic reversal potential, though tools to manipulate chloride levels are limited. Here, the authors combine Archaerhodopsin with a chloride channel opsin to generate an optogenetic chloride extrusion ...
Hannah Alfonsa +3 more
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Optical silencing of C. elegans cells with arch proton pump. [PDF]
PLoS ONE, 2012 BACKGROUND: Optogenetic techniques using light-driven ion channels or ion pumps for controlling excitable cells have greatly facilitated the investigation of nervous systems in vivo. A model organism, C.
Ayako Okazaki, Yuki Sudo, Shin Takagi
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