Results 71 to 80 of about 1,653 (173)
Frontiers in Physiology, 2014 The cardiac action potential (AP) and the consequent cytosolic Ca2+ transient are key indicators of cardiac function. Natural developmental processes, as well as many drugs and pathologies change the waveform, propagation, or variability (between cells ...
Jennifer H Hou +4 more
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International Journal of Molecular Sciences, 2019 QuasAr1 is a fluorescent voltage sensor derived from Archaerhodopsin 3 (Arch) of Halorubrum sodomense by directed evolution. Here we report absorption and emission spectroscopic studies of QuasAr1 in Tris buffer at pH 8. Absorption cross-section spectra,
A. Penzkofer, A. Silapetere, P. Hegemann
semanticscholar +1 more source
Role of Prelimbic GABAergic Circuits in Sensory and Emotional Aspects of Neuropathic Pain
Cell Reports, 2015 Noxious stimuli are detected by peripheral nociceptors and then transmitted to higher CNS centers, where they are perceived as an unpleasant sensation.
Zizhen Zhang +5 more
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Frontiers in Behavioral Neuroscience, 2020 Pain is comprised of both sensory and affective components. The anterior cingulate cortex (ACC) is a key brain region involved in the emotional processing of pain.
Sarah Jarrin +13 more
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MedComm, Volume 7, Issue 2, February 2026.Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo +11 more
wiley +1 more source
Stabilized Ion Selectivity Corrects Activation Drift in Kalium Channelrhodopsins
Advanced Science, Volume 13, Issue 6, 30 January 2026.As newly emerged optogenetic tools, potassium channelrhodopsins (KCRs) can drift from inhibition to activation during illumination as K⁺ selectivity declines. It is shown that both the absolute K⁺/Na⁺ permeability ratio and its stability over time govern this drift, identify KCR1‐C29D as a reliably inhibitory variant, and outline design principles for ...
Xiao Duan +14 more
wiley +1 more source
Microbial light-activatable proton pumps as neuronal inhibitors to functionally dissect neuronal networks in C. elegans. [PDF]
PLoS ONE, 2012 Essentially any behavior in simple and complex animals depends on neuronal network function. Currently, the best-defined system to study neuronal circuits is the nematode Caenorhabditis elegans, as the connectivity of its 302 neurons is exactly known ...
Steven J Husson +5 more
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Review of Multifunctional Neural Probe
Advanced Materials Interfaces, Volume 12, Issue 21, November 10, 2025.Modern multifunctional neural probes for brain‐machine interfaces extend beyond basic electrical functions to incorporate chemical and optical modalities. This review explores recent advances in multifunctional probes developed for neural signal acquisition and stimulation, highlighting how these innovations enhance the precision of brain activity ...
Ziqi Jia, Yong Kyu Yoon
wiley +1 more source
Characterizing optogenetically mediated rebound effects in anaesthetized mouse primary visual cortex
The Journal of Physiology, Volume 603, Issue 16, Page 4609-4636, 15 August 2025.Abstract figure legend Many studies of cortical circuits use optogenetic activation of inhibitory interneurons to suppress pyramidal cell activity, but after the light is turned off pyramidal cells sometimes show excess spiking, which is called a post‐inhibitory rebound.
Jared T. Shapiro +2 more
wiley +1 more source
Optogenetic Pacing: Current Insights and Future Potential
Research Reports in Clinical Cardiology, 2020 Airong Li, Rudolph E Tanzi Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USACorrespondence: Airong Li; Rudolph E TanziGenetics and Aging Research Unit, Department of
Li A, Tanzi RE
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