Results 71 to 80 of about 2,147 (170)

Optogenetic translocation of protons out of penumbral neurons is protective in a rodent model of focal cerebral ischemia

open access: yesBrain Stimulation, 2020
Background: Intracellular acidosis in the ischemic penumbra can contribute to further cell death, effectively enlarging the infarct core. Restoring the acid-base balance may enhance tissue survivability after cerebral ischemia.
Bin Bo   +4 more
doaj   +1 more source

Visualization of myelin‐forming oligodendrocytes in the adult mouse brain

open access: yesJournal of Neurochemistry, Volume 169, Issue 1, January 2025.
Single‐cell RNA sequence data subdivided oligodendrocyte differentiation steps into newly formed oligodendrocytes (NFOLs), myelin‐forming oligodendrocytes (MFOLs), and mature oligodendrocytes (MOLs). We focused on NFOL‐specific RNA, long non‐coding oligodendrocyte 1 (LncOL1) and generated an LncOL1‐tTA mouse line.
Kiichi Yokoyama   +3 more
wiley   +1 more source

Cortical Interneurons Differentially Shape Frequency Tuning following Adaptation

open access: yesCell Reports, 2017
Summary: Neuronal stimulus selectivity is shaped by feedforward and recurrent excitatory-inhibitory interactions. In the auditory cortex (AC), parvalbumin- (PV) and somatostatin-positive (SOM) inhibitory interneurons differentially modulate frequency ...
Ryan G. Natan   +2 more
doaj   +1 more source

Bioelectronic Implantable Devices for Physiological Signal Recording and Closed‐Loop Neuromodulation

open access: yesAdvanced Functional Materials, Volume 34, Issue 41, October 8, 2024.
This review explores bioelectronic implantable devices, which monitor physiological signals and detect diseases early by interfacing with bodily organs. It highlights their use in neuromodulation for precise therapeutic delivery and discusses closed‐loop systems that adapt treatments from real‐time feedback.
Saehyuck Oh   +6 more
wiley   +1 more source

Flexible and Lightweight Devices for Wireless Multi-Color Optogenetic Experiments Controllable via Commercial Cell Phones

open access: yesFrontiers in Neuroscience, 2019
Optogenetics provide a potential alternative approach to the treatment of chronic pain, in which complex pathology often hampers efficacy of standard pharmacological approaches.
Philipp Mayer   +14 more
doaj   +1 more source

Initial photophysical characterization of the proteorhodopsin optical proton sensor (PROPS) [PDF]

open access: yes, 2015
Fluorescence is not frequently used as a tool for investigating the photocycles of rhodopsins, largely because of the low quantum yield of the retinal chromophore.
Nadeau, Jay L.
core   +2 more sources

Different dendritic domains of the GnRH neuron underlie the pulse and surge modes of GnRH secretion in female mice [PDF]

open access: yes, 2020
The gonadotropin-releasing hormone (GnRH) neurons exhibit pulse and surge modes of activity to control fertility. They also exhibit an unusual bipolar morphology comprised of a classical soma-proximal dendritic zone and an elongated secretory process ...

core   +3 more sources

Dopaminergic Neurons in Zona Incerta Drives Appetitive Self‐Grooming

open access: yesAdvanced Science, Volume 11, Issue 36, September 25, 2024.
Dopaminergic neurons in the zona incerta (A13) integrate sensory information and drive self‐grooming and place preference by releasing dopamine to the periaqueductal gray (PAG). The dependency of place preference on self‐grooming suggests that self‐grooming is appetitive.
Zhiying Jiang   +8 more
wiley   +1 more source

Neuromodulation of the peripheral nervous system: Bioelectronic technology and prospective developments

open access: yesBMEMat, Volume 2, Issue 1, March 2024.
Our manuscript describes the crucial role of the peripheral nervous system in health, underscoring the therapeutic potential of neuromodulation for a range of serious medical conditions. In this comprehensive review, we explore various neuromodulation techniques—such as electrical, chemical, optical, and mechanical stimulation—that have been enhanced ...
Hayoung Song   +9 more
wiley   +1 more source

Controlling Interneuron Activity in Caenorhabditis Elegans to Evoke Chemotactic Behaviour [PDF]

open access: yes, 2014
Animals locate and track chemoattractive gradients in the environment to find food. With its small nervous system, Caenorhabditis elegans is a good model system in which to understand how the dynamics of neural activity control this search behaviour ...
Guo, Zengcai V.   +3 more
core   +1 more source

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