Results 81 to 90 of about 1,653 (173)

Optogenetic translocation of protons out of penumbral neurons is protective in a rodent model of focal cerebral ischemia

Brain Stimulation, 2020
Background: Intracellular acidosis in the ischemic penumbra can contribute to further cell death, effectively enlarging the infarct core. Restoring the acid-base balance may enhance tissue survivability after cerebral ischemia.
Bin Bo, Yao Li, Wanlu Li, Yongting Wang, Shanbao Tong   +4 more
doaj   +1 more source

Cortical Interneurons Differentially Shape Frequency Tuning following Adaptation

Cell Reports, 2017
Summary: Neuronal stimulus selectivity is shaped by feedforward and recurrent excitatory-inhibitory interactions. In the auditory cortex (AC), parvalbumin- (PV) and somatostatin-positive (SOM) inhibitory interneurons differentially modulate frequency ...
Ryan G. Natan, Winnie Rao, Maria N. Geffen   +2 more
doaj   +1 more source

Visualization of myelin‐forming oligodendrocytes in the adult mouse brain

Journal of Neurochemistry, Volume 169, Issue 1, January 2025.
Single‐cell RNA sequence data subdivided oligodendrocyte differentiation steps into newly formed oligodendrocytes (NFOLs), myelin‐forming oligodendrocytes (MFOLs), and mature oligodendrocytes (MOLs). We focused on NFOL‐specific RNA, long non‐coding oligodendrocyte 1 (LncOL1) and generated an LncOL1‐tTA mouse line.
Kiichi Yokoyama, Yuichi Hiraoka, Yoshifumi Abe, Kenji F. Tanaka   +3 more
wiley   +1 more source

Flexible and Lightweight Devices for Wireless Multi-Color Optogenetic Experiments Controllable via Commercial Cell Phones

Frontiers in Neuroscience, 2019
Optogenetics provide a potential alternative approach to the treatment of chronic pain, in which complex pathology often hampers efficacy of standard pharmacological approaches.
Philipp Mayer, Philipp Mayer, Nandhini Sivakumar, Michael Pritz, Matjia Varga, Andreas Mehmann, Seunghyun Lee, Alfredo Salvatore, Michele Magno, Matt Pharr, Helge C. Johannssen, Gerhard Troester, Hanns Ulrich Zeilhofer, Giovanni Antonio Salvatore, Giovanni Antonio Salvatore   +14 more
doaj   +1 more source

Triton X‐100 can alter the temporal sequence of the light‐driven proton pump of archaerhodopsin 4 [PDF]

FEBS Letters, 2006
We report that Triton X‐100 can alter the temporal sequence of the light‐induced proton uptake and release of archaerhodopsin 4 (AR4), a proton pumping protein in a species of Halobacteria from a Tibetan salt lake. Under physiological conditions, AR4 isolated from the bacterium exhibits a reversed temporal order of proton release and uptake compared to
Ming, Ming, Wang, Yazhuo, Wu, Jia, Ma, Dewang, Li, Qingguo, Ding, Jiandong   +5 more
openaire   +2 more sources

Bioelectronic Implantable Devices for Physiological Signal Recording and Closed‐Loop Neuromodulation

Advanced Functional Materials, Volume 34, Issue 41, October 8, 2024.
This review explores bioelectronic implantable devices, which monitor physiological signals and detect diseases early by interfacing with bodily organs. It highlights their use in neuromodulation for precise therapeutic delivery and discusses closed‐loop systems that adapt treatments from real‐time feedback.
Saehyuck Oh, Janghwan Jekal, Jia Liu, Jeehwan Kim, Jang‐Ung Park, Taeyoon Lee, Kyung‐In Jang   +6 more
wiley   +1 more source

Dopaminergic Neurons in Zona Incerta Drives Appetitive Self‐Grooming

Advanced Science, Volume 11, Issue 36, September 25, 2024.
Dopaminergic neurons in the zona incerta (A13) integrate sensory information and drive self‐grooming and place preference by releasing dopamine to the periaqueductal gray (PAG). The dependency of place preference on self‐grooming suggests that self‐grooming is appetitive.
Zhiying Jiang, Michelle He, Claire Young, Jing Cai, Yuanzhong Xu, Yanyan Jiang, Hongli Li, Maojie Yang, Qingchun Tong   +8 more
wiley   +1 more source

Neuromodulation of the peripheral nervous system: Bioelectronic technology and prospective developments

BMEMat, Volume 2, Issue 1, March 2024.
Our manuscript describes the crucial role of the peripheral nervous system in health, underscoring the therapeutic potential of neuromodulation for a range of serious medical conditions. In this comprehensive review, we explore various neuromodulation techniques—such as electrical, chemical, optical, and mechanical stimulation—that have been enhanced ...
Hayoung Song, Moohyun Kim, Enji Kim, Jakyoung Lee, Inhea Jeong, Kyeonghee Lim, Seoung Young Ryu, Myoungjae Oh, Younhee Kim, Jang‐Ung Park   +9 more
wiley   +1 more source

Near‐Infrared‐Responsive Rare Earth Nanoparticles for Optical Imaging and Wireless Phototherapy

Advanced Science, Volume 11, Issue 8, February 23, 2024.
In this review, the authors focus on rare earth nanoparticles (RENPs) as media for light conversion and discuss the photoconversion process under near‐infrared (NIR) excitation, as well as recent achievements in optical imaging, photothermal therapy, photodynamic therapy, photoimmunotherapy, optogenetics, and light‐responsive drug release. Finally, the
Pengye Du, Yi Wei, Yuan Liang, Ran An, Shuyu Liu, Pengpeng Lei, Hongjie Zhang   +6 more
wiley   +1 more source

Site‐specific inhibition of the thalamic reticular nucleus induces distinct modulations in sleep architecture

European Journal of Neuroscience, Volume 59, Issue 4, Page 554-569, February 2024.
During sleep caudal and rostral subpopulations of the TRN exert diverse activities. Silencing of the rostral TRN elongates sleep episodes, while silencing of the caudal TRN fragments sleep. Silencing of both TRN areas is associated with changes in delta and alpha oscillations.
Vladimir Visocky, Brian J. Morris, John Dunlop, Nick Brandon, Shuzo Sakata, Judith A. Pratt   +5 more
wiley   +1 more source