Results 51 to 60 of about 22,053,960 (269)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Inferring End‐Members From Geoscience Data Using Simplex Projected Gradient Descent‐Archetypal Analysis

Journal of Geophysical Research: Machine Learning and Computation
End‐member mixing analysis (EMMA) is widely used to analyze geoscience data for their end‐members and mixing proportions. Many traditional EMMA methods depend on known end‐members, which are sometimes uncertain or unknown. Unsupervised EMMA methods infer
Zanchenling Wang, Tao Wen
doaj   +1 more source

Archetypowe i sakralne podstawy rosyjskiej kultury politycznej

Politeja, 2015
Archetypal and sacred grounds of the Russian political culture The article provides the analysis of the basic archetypal and sacred symbols of Russian political culture.
Irina Wasilenko
doaj   +1 more source

Archetypal Analysis and its application in bioinformatics

, 2023
reservedL’archetypal analysis (AA) è un metodo statistico che permette di analizzare grandi data set estraendo da essi degli archetipi. Viene utilizzata in molti ambiti, tra cui quello della bioinformatica, principalmente per semplificare l’analisi di ...
PASQUETTO, AURORA
core  

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

A data-driven classification of 3D foot types by archetypal shapes based on landmarks.

PLoS ONE, 2020
The taxonomy of foot shapes or other parts of the body is important, especially for design purposes. We propose a methodology based on archetypoid analysis (ADA) that overcomes the weaknesses of previous methodologies used to establish typologies. ADA is
Aleix Alcacer, Irene Epifanio, M Victoria Ibáñez, Amelia Simó, Alfredo Ballester   +4 more
doaj   +1 more source

Archetypal analysis for data driven benchmarking

, 2006
In this work, adopting an exploratory and graphical approach, we suggest to consider archetypal analysis as a basis for a data driven benchmarking procedure.
VISTOCCO D, RAGOZINI G, G. PORZIO
core   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source