Results 31 to 40 of about 14,357 (217)

Genome-wide prediction of topoisomerase IIβ binding by architectural factors and chromatin accessibility.

PLoS Computational Biology, 2021
DNA topoisomerase II-β (TOP2B) is fundamental to remove topological problems linked to DNA metabolism and 3D chromatin architecture, but its cut-and-reseal catalytic mechanism can accidentally cause DNA double-strand breaks (DSBs) that can seriously ...
Pedro Manuel Martínez-García, Miguel García-Torres, Federico Divina, José Terrón-Bautista, Irene Delgado-Sainz, Francisco Gómez-Vela, Felipe Cortés-Ledesma   +6 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Acessibilidade aos serviços de saúde: uma análise a partir da Atenção Básica em Pernambuco

Saúde em Debate
Analisou-se a acessibilidade aos serviços de saúde de Atenção Básica em Pernambuco e os aspectos que favorecem ou dificultam a entrada e a permanência do usuário no sistema de saúde.
Maria do Socorro Veloso de Albuquerque, Tereza Maciel Lyra, Sidney Feitoza Farias, Marina Ferreira de Medeiros Mendes, Petrônio José de Lima Martelli   +4 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Architectural and planning solutions for multistorey residential buildings with safety capsules [PDF]

E3S Web of Conferences
The purpose of this study is to develop an architectural and construction solution for protecting the civilian population in a multi-story residential building by creating a safe space with instant accessibility.
Bordun Maryna, Bevz Mykola, Shekhorkina Svitlana, Nevgomonnyi Hryhorii, Krutiy Yuriy   +4 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Glazkovo Spit (Zaton): problems and future development

Проект Байкал, 2018
The article presents projects worked out in different years by architectural students under the supervision of the architects Lyubov Nikolaevna Makogon and Roman Alexandrovich Selivanov, assistant professors of the Department of Architectural Design of ...
Lyubov Makogon, Roman Selivanov
doaj   +1 more source

Analysis of Building Accessibility Using Inertial and Optical Sensors

Sensors, 2023
The inclusive use of urban spaces necessitates detailed knowledge of the accessibility of public buildings or places where educational, health or administrative services are provided.
Tomás E. Martínez-Chao, Agustín Menéndez-Díaz, Silverio García-Cortés, Pierpaolo D’Agostino   +3 more
doaj   +1 more source