Results 51 to 60 of about 48,001 (282)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Architecture and Globalization, a very intimate relationship

arq.urb, 2022
The invitation to write this article gave rise to a review of my studies and writings produced in the last twenty-five years about the approximation between architecture and globalization.
Fernando Lara
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

THE COMBINATION OF THE IMAGE AND RANGE-BASED 3D ACQUISITION IN ARCHAEOLOGICAL AND ARCHITECTURAL RESEARCH IN THE ROYAL CASTLE IN WARSAW [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2019
The paper presents archaeological and architectural research in the Royal Castle in Warsaw where a combination of image- and range-based 3D acquisition was applied.
A. Bocheńska, J. Markiewicz, S. Łapiński   +2 more
doaj   +1 more source

Rediscovering architecture : paestum in eighteenth-century architectural experience and theory, by Sigrid de Jong [PDF]

, 2018
Book review of: Sigrid de Jong, Rediscovering Architecture: Paestum in Eighteenth-Century Architectural Experience and Theory. New Haven, Conn.: Yale University Press, 2015, 352 pp., 100 color and 185 b/w illus.
De Meyer, Dirk
core   +2 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Exclusive Histories, Unseen Narratives

Architektúra & Urbanizmus
The canon is generally understood as a body of the most important personalities and key works in a particular field, and for various reasons it evokes an impression of objectivity and impartiality.
Klára Brůhová
doaj   +1 more source

Drawing images or Architectural drawing

Disegnare con, 2013
In this article we will discuss how the aesthetic values, that the digital imaging provide, has influenced in drawing and architecture in a historical reading of the evolution of each means of architecture expression. In painting art and photography have
Amparo Bernal López-Sanvicente
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

0326 Architekt:innen-Monographien. Zur Revision eines wissenschaftlichen Publikationsformats

RIHA Journal
This article examines the origins of the monograph as a publication format dedicated to individual architects and explores how such person-centered narratives in architectural history are, or might be, written today in light of contemporary concerns such
Ruth Hanisch, Richard Kurdiovsky, Bernadette Reinhold, Antje Senarclens de Grancy   +3 more
doaj   +1 more source