Results 51 to 60 of about 751,174 (286)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Architectural design rewriting as an architecture description language [PDF]
, 2008 Architectural Design Rewriting (ADR) is a declarative rule-based approach for the design of dynamic software architectures. The key features that make ADR a suitable and expressive framework are the algebraic presentation of graph-based structures and ...
Bruni, Roberto +3 more
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Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Houses in Malaysia: Fusion of the east and the west [PDF]
, 2005 A great number of architectural scholars in Malaysia learned about western architecture to be used as precedent studies in their design. Few realized that part of the origin of the modern western architecture was actually from the east.
Wan Ismail, Wan Hashimah
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Reflections about the creative process of the architectural project and its teaching [PDF]
, 2017 This paper aims to reflect on the importance of the eye in the creative process of architectural projects. All creation is based on a watchful eye, which acts as an instrument of knowledge and reflection; an active and creative eye that contains a ...
Alba-Dorado, Maria Isabel
core +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Case analysis and design logic framework of eco-environment-oriented development (EOD) in China
Journal of Asian Architecture and Building EngineeringAs China undergoes a strategic shift from a growth-centric development paradigm to one that prioritizes environmental sustainability, the Eco-Environment-Oriented Development (EOD) model has emerged as a policy innovation and is currently being ...
Lu Li, Le Luo, Yang Qu, Mao Han
doaj +1 more source
Analysing how constraints impact architectural decision-making [PDF]
, 2015 Architectural design projects are characterised by a high number of constraints. Along with planning, energy performance and fire safety regulations, current designers have to face constraining factors related to budget, acoustics, orientation, wind ...
De Meyer, Ronald +2 more
core +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Modelling process knowledge in architectural design: A case-based approach [PDF]
, 1995 The paper presents on-going research aimed at the understanding and support of process knowledge in architectural design, from early and not sufficiently defined, to satisfactorily-defined phases.
Arlati, Ezio +3 more
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