Results 61 to 70 of about 751,174 (286)
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Scientific ReportsWoody ornamentals hold significant promise for phytoremediation. However, the cadmium (Cd) tolerance and accumulation ability of the commonly planted Lagerstroemia indica, have not been insufficiently studied. This study evaluated four L.
Jing Li +5 more
doaj +1 more source
Computational support for early stage architectural design [PDF]
, 2007 The concepts underlying 'scenario-based' design are introduced. From the analysis of a number of struc-tured interviews with practicing designers, key design scenarios are identified.
Bridges, A.H.
core
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Architectural design of groupware systems: a component-based approach [PDF]
, 2002 Different stakeholders in the design of an enterprise information system have their own view on that design. To help produce a coherent design this paper presents a framework that aids in specifying relations between such views.
Guareis de Farias, Cléver Ricardo
core +12 more sources
Handling Data Heterogeneity via Architectural Design for Federated Visual Recognition [PDF]
, 2023 Sara Pieri +3 more
openalex +1 more source
A Qualitative Method for Assessing the Impact of ICT on the Architectural Design Process [PDF]
, 2013 During the last thirty years or so, we have witnessed tremendous developments in information and communication technology (ICT). Computer processing power doubles each 18 months, as Gordon Moore predicted during the mid-1960s.
Ganah, Abdulkadir, Kamara, John
core
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Enforcing Architectural Styles in Presence of Unexpected Distributed Reconfigurations
, 2012 Architectural Design Rewriting (ADR, for short) is a rule-based formal framework for modelling the evolution of architectures of distributed systems. Rules allow ADR graphs to be refined.
Poyias, Kyriakos, Tuosto, Emilio
core +2 more sources
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source