Results 71 to 80 of about 182,286 (288)

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Digital Documentation and Analysis of Palladian Microarchitectures: From 3D Models to Knowledge-Based Information Systems

Heritage
Chimneypieces, washbasins, well heads, and sinks by Andrea Palladio represent refined design works following architectural systems on a reduced scale, even if systematic documentation and analysis of them is still limited.
Simone Baldissini, Simone Garagnani
doaj   +1 more source

D2.8 Architecture Design Document

, 2023
This document is the final version of the deliverable, presenting the overall principles and components, over a 3-tier layered structure, to achieve interoperable functions in a federated approach. It establishes the services and functions required to support the VALKYRIES SIGRUN and the established the design API interfaces for a integration of the ...
Miguel, Pedro, Manso, Marco, Guerra, Barbara   +2 more
openaire   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Rationale Management Challenges in Requirements Engineering [PDF]

, 2010
Rationale and rationale management have been playing an increasingly prominent role in software system development mainly due to the knowledge demand during system evaluation, maintenance, and evolution, especially for large and complex systems.
Avgeriou, Paris,, He, Keqing,, Liang, Peng,   +2 more
core   +3 more sources

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Classification of Architectural Heritage Images Using Deep Learning Techniques

Applied Sciences, 2017
The classification of the images taken during the measurement of an architectural asset is an essential task within the digital documentation of cultural heritage.
Jose Llamas, Pedro M. Lerones, Roberto Medina, Eduardo Zalama, Jaime Gómez-García-Bermejo   +4 more
doaj   +1 more source

Documenting Software Architectures: Organization of Documentation Package [PDF]

, 2001
Abstract : This report represents a milestone of a work in progress. That work is a comprehensive handbook on how to produce high-quality documentation for software architectures. The handbook, tentatively entitled Documenting Software Architectures, will be published in early 2002 by Addison Wesley Longman as part of the SEI Series on Software ...
James Ivers, David Garlan, Paul Clements, Len Bass, Felix Bachmann   +4 more
openaire   +1 more source

Analysis and Synthesis of Metadata Goals for Scientific Data [PDF]

, 2012
The proliferation of discipline-specific metadata schemes contributes to artificial barriers that can impede interdisciplinary and transdisciplinary research.
Bain, Baker, Blank, Bountouri, Bosch, Brazma, Bruce, Buschmann, Committee on Science, Engineering, and Public Policy (US), and Committee on Ensuring the Utility and Integrity of Research Data in a Digital Age, Consultative Committee for Space Data Systems (CCSDS), Duval, Frenkel, Garvey, Greenberg, Greenberg, Greenberg, Greenberg, Hall, Hall, Heidorn, Hey, Higgins, Hjørland, Hubenthal, Jones, Kelling, Klein, Krippendorff, Lide, Lim, Michener, Murray-Rust, National Science Foundation, NSF Task Force on Cyberlearning, Rayner, Ryssevik, Sommerville, Spellman, Spurgin, Stvilia, Westbrook, Westbrook, Zhang   +42 more
core   +3 more sources

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source