Results 71 to 80 of about 183,206 (297)

ARCHITECTURAL HERITAGE DOCUMENTATION BY USING LOW COST UAV WITH FISHEYE LENS: OTAG-I HUMAYUN IN ISTANBUL AS A CASE STUDY [PDF]

ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2017
The digital documentation of architectural heritage is important for monitoring, preserving, managing as well as 3B BIM modelling, time-space VR (virtual reality) applications.
N. Yastikli, Ö. Z. Özerdem
doaj   +1 more source

D2.8 Architecture Design Document

, 2023
This document is the final version of the deliverable, presenting the overall principles and components, over a 3-tier layered structure, to achieve interoperable functions in a federated approach. It establishes the services and functions required to support the VALKYRIES SIGRUN and the established the design API interfaces for a integration of the ...
Miguel, Pedro, Manso, Marco, Guerra, Barbara   +2 more
openaire   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Documenting Software Architectures: Organization of Documentation Package [PDF]

, 2001
Abstract : This report represents a milestone of a work in progress. That work is a comprehensive handbook on how to produce high-quality documentation for software architectures. The handbook, tentatively entitled Documenting Software Architectures, will be published in early 2002 by Addison Wesley Longman as part of the SEI Series on Software ...
James Ivers, David Garlan, Paul Clements, Len Bass, Felix Bachmann   +4 more
openaire   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Towards a re-engineering method for web services architectures [PDF]

, 2004
Recent developments in Web technologies – in particular through the Web services framework – have greatly enhanced the flexible and interoperable implementation of service-oriented software architectures.
Barrett, Ronan, Pahl, Claus
core   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

THE ROLE OF EKREM HAKKI AYVERDİ IN CONSERVATION OF THE OTTOMAN ARCHITECTURAL HERITAGE IN THE BALKANS [PDF]

, 2013
Historic conservation and enhancement of the architectural heritage requires constant struggle against time, since various effects work against the preservation of historic buildings.
Yuksel Sayan
core