Results 121 to 130 of about 5,176,755 (302)

ADP‐ribosylation: An emerging regulator of the epigenome

open access: yesMolecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho   +2 more
wiley   +1 more source

An investigation of architectural acoustics with an illustrative example : comprising the S.B. thesis

open access: yes, 1923
Thesis: B. Arch., Massachusetts Institute of Technology, Department of Architectural Engineering, 1923Includes bibliographical references (leaf vi).Robert Wales Reno.B. Arch.B. Arch.
Reno, Robert Wales.
core  

Architectural caring. Architectural qualities from a residential property perspective

open access: yes, 2013
A common definition of architectural qualities in general and the values of the qualities in particular can differ significantly in the understanding of different operators in the building construction sector.
Olofsson, Thomas,, Nordwall, Ulf,
core   +1 more source

Evaluation of the Sulfate Erosion Resistance in Fly Ash Concrete Subjected to Electric Fields

open access: yesAdvances in Civil Engineering
Right now, there are limited studies on how concrete soil resists sulfate when an electric field and fly ash are used together, and the theory behind stray current engineering protection is not fully developed. This study looks at concrete mixed with fly
Huanqin Liu   +5 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

open access: yesMolecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Technology Architectural Review [PDF]

open access: yes, 1887
Publication of the Massachusetts Institute of Technology Architectural Society. Volume 3.
Massachusetts Institute of Technology. Department of Architecture   +1 more
core  

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

open access: yesMolecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

open access: yesMolecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh   +11 more
wiley   +1 more source

Actors and Vehicles of Architectural Criticism (1)

open access: yes, 2016
Actors of Criticism: How the Editors of AD Magazine shaped Architecture Stephen Parnell Newcastle University From its establishment in 1930, architect John Kendall briefly edited Architectural Design (AD) magazine until his death in 1934 when Frederic ...
Mapping Architectural Criticism
core   +1 more source

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