Results 111 to 120 of about 5,176,755 (302)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
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Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
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Actors and Vehicles of Architectural Criticism (8)
, 2016 Antwerp Architectural Exhibitions as Critical Actor in Belgium 1883-1972 Ellen Van Impe Centre for Flemish Architectural Archives, Vlaamse Architectuur Instituut (Flanders Architecture Institute) During the last quarter of the nineteenth century, the ...
Mapping Architectural Criticism
core
, 2007 In 1997 a new education in Architecture & Design at Department of Architecture and Design, Aalborg University was started with 50 students. During the recent years this number has increased to approximately 100 new students each year, i.e. approximately 500 students are following the 3 years bachelor (BSc) and the 2 years master (MSc) programme ...
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CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
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, 2022 Despite its significant implications in terms of technical skills, professions and education, research about mafias has never been a mainstream subject in Architecture and Engineering academic disciplines. Although the database does not accurately capture yet the entirety of the Italian scholars scientific production, it is evident that attention to ...
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Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
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Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
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Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
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A DIKW Architecture for Cognitive Engineering
Procedia Computer Science, 2018 Abstract Though the word “cognitive” has a wide range of meanings we define cognitive engineering as learning from brain to bolster engineering solutions. However, giving an achievable framework to the process towards this has been a difficult task.
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