Results 91 to 100 of about 90,450 (311)
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Problem based learning in architectural education [PDF]
, 2007 There is limited published research and discussion on pedagogical approaches in architectural education. Problem (or Project) Based Learning is used successfully in other professional disciplines, and, consequently, there have been attempts to utilise ...
Bridges, Alan
core
, 2010 London-based Adams Kara Taylor (AKT) is one of the most innovative design-led structural and civll engineering practices in the UK. Seeking out creative collaborations with leading architectural fi rms and schools of architecture and design ...
Hanif Kara, Kara, Hanif,
core +1 more source
Section II.—Engineering and Architecture [PDF]
Journal of the Royal Sanitary Institute, 1904 n ...
openaire +4 more sources
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Agile Construction and Evolution of Product-Line Architectures [PDF]
, 2012 Software Product Line Engineering (SPLE) has proved to have significant advantages in family-based software development, but also implies the up¬front design of a product-line architecture (PLA) from which individual product applications can be ...
Díaz Fernández, Jessica
core +2 more sources
Architectural Retrofit and Multidisciplinary HVAC Modernization with BIM Methodology: A Study of the Carlos Tortelly Municipal Hospital [PDF]
E3S Web of ConferencesThe modernization of existing public hospitals requires an integrated approach capable of addressing architectural constraints, outdated engineering systems, and evolving regulatory requirements for indoor air quality, energy efficiency, and operational ...
Fugazza Kátia +2 more
doaj +1 more source
Enterprise Architecture and Systems Engineering [PDF]
, 2003 Factors such as the end of the cold war and increasing globalisation in terms of competition and social responsibility have significantly increased the complexity of events addressed both by governments and by industry. Furthermore, their responses are increasingly more constrained by economic and environmental issues.
openaire +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source