Results 41 to 50 of about 59,563 (247)

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Assessing The Economic Feasibility of Applying Integrated Photo Voltaic (BIPV) System in Residential Buildings in Egypt

Journal of Architecture, Art & Humanistic Science
Nowadays, the human need for electrical energy is escalating due to the growing demand of modern life applications, however, the increasing demand for fossil fuel sources for electricity production has led to the climate changes.
Prof. Safaa Mahmoud Issa Professor Architectural Department – Faculty of Engineering – Menoufia University, assist. Lect. Ahmed Ayman Eissa Assistant Lecturer Architectural Department – Faculty of Engineering – Menoufia University   +1 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Reworlding the Archive: Robin Boyd, Gregory Burgess and Indigenous Knowledge in the Architectural Archive.” between Architecture and Engineering [PDF]

, 2022
Peter Raisbeck
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The Impact of AI-Powered Platforms and Tools on Architectural Education

Journal of Architecture, Art & Humanistic Science
The integration of artificial intelligence AI into educational processes has been a topic of increasing interest across various disciplines. In the field of architecture, where creativity, design thinking, and technical proficiency are paramount, the use
Assist.Prof. Dr. Maha Fawzy Aly Anber 1Associate Professor of Architecture- Architectural engineering department- Higher Institute of Engineering in Shorouk City- Shorouk Academy- Egypt;
doaj   +1 more source

Form generation and modelling of complex spatial solutions in sacral construction under the influence of modern structural and building technologies and calculation methodologies [PDF]

Дороги і мости
ntroduction. The article addresses the issue of designing complex architectural forms in modern sacred architecture, with a focus on structural feasibility and engineering analysis.
Alexei Yaschenko, Serhii Kelba
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The Relationship Between The Creation Abilities and Architectural Design Process- Students of Department of Architecture at University of Sulaimany as a Case study

Sulaimani Journal for Engineering Sciences, 2014
Creating is one of the needs of the mental and physical creation , and architectural design has the intercommunication between science and creation to reach student to the creative level especially in architectural design , this research study the ...
Alan Fraidoon Ali, Chro Mohammed Ali
doaj   +1 more source