Results 61 to 70 of about 5,176,755 (302)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The changing patterns of architectural design education [PDF]

, 2008
Digital technologies have been introduced to students of architecture for over two decades and at present it could be argued that students are producing some of the highest quality designs, and some of the most interesting forms ever to come from ...
Horne, Margaret, Giddings, Bob
core  

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Assessing The Economic Feasibility of Applying Integrated Photo Voltaic (BIPV) System in Residential Buildings in Egypt

Journal of Architecture, Art & Humanistic Science
Nowadays, the human need for electrical energy is escalating due to the growing demand of modern life applications, however, the increasing demand for fossil fuel sources for electricity production has led to the climate changes.
Prof. Safaa Mahmoud Issa Professor Architectural Department – Faculty of Engineering – Menoufia University, assist. Lect. Ahmed Ayman Eissa Assistant Lecturer Architectural Department – Faculty of Engineering – Menoufia University   +1 more
doaj   +1 more source

A First Model Foundation Design of Wood Pillar in Banjarmasin Swampland

ASEAN Journal on Science and Technology for Development
Banjarmasin's swampland presents distinct characteristics that make it suitable for constructing homes, but it also requires special attention, especially concerning the foundation.
Nursyarif Agusniansyah, Gusti Novi Sarbini, Akbar Rahman, Muhammad Tharziansyah   +3 more
doaj   +1 more source

Shape grammars as a reverse engineering method for the morphogenesis of architectural façade design

Frontiers of Architectural Research, 2019
The field of shape grammars spans 47 years, but its potential in the practice and education of art, architecture, and engineering remains far from being utilized.
Buthayna Eilouti
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Layered patterns in modelling and transformation of service-based software architectures [PDF]

, 2006
Service-oriented architecture is a recent paradigm for architectural design. The software engineering aspects in this context, that have not been sufficiently addressed, are software evolution and software migration. Architectures are of great importance
Pahl, Claus, Barrett, Ronan
core   +3 more sources

Research on the application status and countermeasures of traditional architectural elements in architectural environment design [PDF]

SHS Web of Conferences
Traditional architectural elements carry our excellent traditional culture, contain rich connotation, and are the valuable wealth of modern architectural environment design research and reference.
Yuan Yifan, Ren Hao
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source