Results 61 to 70 of about 432,865 (290)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Transforming a Cantilever with Fixed Joints into Trussed Configurations: A Case Study in Creative Design Thinking & Prototyping

Architecture, Civil Engineering, Environment
In the design of structures, joint design significantly influences aesthetics, structural performance, tectonics, and member geometry. In this study, a Y-shaped, polyhedral cantilever with fixed joints was transformed into five different trussed ...
Filz Günther H., Eberle Robert, Nagl Pia V., Weinold Thomas   +3 more
doaj   +1 more source

Theoretical Engineering and Satellite Comlink of a PTVD-SHAM System [PDF]

, 2007
This paper focuses on super helical memory system's design, 'Engineering, Architectural and Satellite Communications' as a theoretical approach of an invention-model to 'store time-data'.
Alipour, Philip B.
core  

A Formal Architectural Description Language based on Symbolic Transition Systems and Modal Logic [PDF]

, 2006
International audienceComponent Based Software Engineering has now emerged as a discipline for system development. After years of battle between component platforms, the need for means to abstract away from specific implementation details is now ...
Poizat, Pascal, Royer, Jean-Claude
core   +5 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Assessing The Economic Feasibility of Applying Integrated Photo Voltaic (BIPV) System in Residential Buildings in Egypt

Journal of Architecture, Art & Humanistic Science
Nowadays, the human need for electrical energy is escalating due to the growing demand of modern life applications, however, the increasing demand for fossil fuel sources for electricity production has led to the climate changes.
Prof. Safaa Mahmoud Issa Professor Architectural Department – Faculty of Engineering – Menoufia University, assist. Lect. Ahmed Ayman Eissa Assistant Lecturer Architectural Department – Faculty of Engineering – Menoufia University   +1 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Architecture Engineering Developments

, 2016
This presentation will demonstrate some of the buildings, structural frames, mechanical systems, and infrastructure I worked on for my Architectural Engineering Senior Design projects. The first included an 80-story skyscraper and plaza. For the project, the leaning design had to be resolved architecturally with complete and detailed renderings of the ...
Drake, Paul, Rasmussen, Bren, Bales, Libby, Delach, Nic, Lange, Amanda, Wessel, Lindsey, Oolman, Matt, Manhas, Karan, Alhaini, Humoud, McMorrow, Gabrielle   +9 more
openaire   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source