Results 61 to 70 of about 428,058 (275)

Towards a re-engineering method for web services architectures [PDF]

, 2004
Recent developments in Web technologies – in particular through the Web services framework – have greatly enhanced the flexible and interoperable implementation of service-oriented software architectures.
Barrett, Ronan, Pahl, Claus
core   +1 more source

Towards Realizability Checking of Contracts using Theories

, 2015
Virtual integration techniques focus on building architectural models of systems that can be analyzed early in the design cycle to try to lower cost, reduce risk, and improve quality of complex embedded systems.
Backes, John, Cofer, Darren, Gacek, Andrew, Katis, Andreas, Whalen, Michael W.   +4 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Research and Education in Computational Science and Engineering [PDF]

, 2016
Over the past two decades the field of computational science and engineering (CSE) has penetrated both basic and applied research in academia, industry, and laboratories to advance discovery, optimize systems, support decision-makers, and educate the ...
Biros, George, Bungartz, Hans, Corones, James, Cramer, Evin, Crowley, James, De Sterck, Hans, Ghattas, Omar, Gunzburger, Max, Hanke, Michael, Harrison, Robert, Heroux, Michael, Hesthaven, Jan, Jimack, Peter, Johnson, Chris, Jordan, Kirk E., Keyes, David E., Krause, Rolf, Kumar, Vipin, Mayer, Stefan, McInnes, Lois Curfman, Meza, Juan, Mørken, Knut Martin, Oden, J. Tinsley, Petzold, Linda, Raghavan, Padma, Rüde, Ulrich, Shontz, Suzanne M., Trefethen, Anne, Turner, Peter, Voevodin, Vladimir, Willcox, Karen, Wohlmuth, Barbara, Woodward, Carol S.   +32 more
core   +2 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Rock Fracture Response Exposed to Hydraulic Fracturing: Insight into the Effect of Injection Rate on Aperture Pattern

Advances in Materials Science and Engineering, 2022
Injection rate is critical to hydraulic fracturing operation, especially to the hydraulic fracture aperture, which affects the proppant and methane migration.
Bo Zhang, Xinyi Cui, Linjun Wang, Xiaodi Fu   +3 more
doaj   +1 more source

Mediating Cognitive Transformation with VR 3D Sketching during Conceptual Architectural Design Process [PDF]

, 2011
Communications for information synchronization during the conceptual design phase require designers to employ more intuitive digital design tools. This paper presents findings of a feasibility study for using VR 3D sketching interface in order to replace
B. Abdullah, Muhamad Taufik, B. Hj Jaafar, Mohd Saleh, Ibrahim, Rahinah, Pour Rahimian, Farzad, Wirza Binti O. K. Rahmat, Rahmita   +4 more
core   +3 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Research on the application status and countermeasures of traditional architectural elements in architectural environment design [PDF]

SHS Web of Conferences
Traditional architectural elements carry our excellent traditional culture, contain rich connotation, and are the valuable wealth of modern architectural environment design research and reference.
Yuan Yifan, Ren Hao
doaj   +1 more source

A MDE-based optimisation process for Real-Time systems [PDF]

, 2010
The design and implementation of Real-Time Embedded Systems is now heavily relying on Model-Driven Engineering (MDE) as a central place to define and then analyze or implement a system.
Gilles, Olivier, Hugues, Jérôme
core   +1 more source