Results 61 to 70 of about 4,288,284 (360)

Ontology-based modelling of architectural styles [PDF]

, 2009
The conceptual modelling of software architectures is of central importance for the quality of a software system. A rich modelling language is required to integrate the different aspects of architecture modelling, such as architectural styles, structural
Giesecke, Simon, Hasselbring, Wilhelm, Pahl, Claus   +2 more
core   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Using real options to select stable Middleware-induced software architectures [PDF]

, 2005
The requirements that force decisions towards building distributed system architectures are usually of a non-functional nature. Scalability, openness, heterogeneity, and fault-tolerance are examples of such non-functional requirements.
Bahsoon, R., Emmerich, W., Macke, J.
core   +1 more source

Section II.—Engineering and Architecture [PDF]

Transactions of the Sanitary Institute of Great Britain, 1887
n ...
openaire   +2 more sources

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Application and Assessment of an Experiential Deformation Approach as a Didactive Tool of Truss Structures in Architectural Engineering

Education Sciences
Experiential learning methods are advantageous for students as they motivate them to comprehend structural concepts without complex calculations, enhancing their inherent understanding of static principles.
Maristella E. Voutetaki
doaj   +1 more source

Microservices and Machine Learning Algorithms for Adaptive Green Buildings [PDF]

, 2019
In recent years, the use of services for Open Systems development has consolidated and strengthened. Advances in the Service Science and Engineering (SSE) community, promoted by the reinforcement of Web Services and Semantic Web technologies and the ...
Alonso Montesinos, Joaquín Blas, Ayala Palenzuela, Rosa María, Capobianco Uriarte, María De Las Mercedes, Criado Rodríguez, Javier, Iribarne Martínez, Luis Fernando, Piedra Fernández, José Antonio, Rodríguez Gracia, Diego   +6 more
core   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Transforming a Cantilever with Fixed Joints into Trussed Configurations: A Case Study in Creative Design Thinking & Prototyping

Architecture, Civil Engineering, Environment
In the design of structures, joint design significantly influences aesthetics, structural performance, tectonics, and member geometry. In this study, a Y-shaped, polyhedral cantilever with fixed joints was transformed into five different trussed ...
Filz Günther H., Eberle Robert, Nagl Pia V., Weinold Thomas   +3 more
doaj   +1 more source

Towards a re-engineering method for web services architectures [PDF]

, 2004
Recent developments in Web technologies – in particular through the Web services framework – have greatly enhanced the flexible and interoperable implementation of service-oriented software architectures.
Barrett, Ronan, Pahl, Claus
core   +1 more source