Results 61 to 70 of about 4,062,018 (335)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

The Impact of AI-Powered Platforms and Tools on Architectural Education

Journal of Architecture, Art & Humanistic Science
The integration of artificial intelligence AI into educational processes has been a topic of increasing interest across various disciplines. In the field of architecture, where creativity, design thinking, and technical proficiency are paramount, the use
Assist.Prof. Dr. Maha Fawzy Aly Anber 1Associate Professor of Architecture- Architectural engineering department- Higher Institute of Engineering in Shorouk City- Shorouk Academy- Egypt;
doaj   +1 more source

Form generation and modelling of complex spatial solutions in sacral construction under the influence of modern structural and building technologies and calculation methodologies [PDF]

Дороги і мости
ntroduction. The article addresses the issue of designing complex architectural forms in modern sacred architecture, with a focus on structural feasibility and engineering analysis.
Alexei Yaschenko, Serhii Kelba
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

The Relationship Between The Creation Abilities and Architectural Design Process- Students of Department of Architecture at University of Sulaimany as a Case study

Sulaimani Journal for Engineering Sciences, 2014
Creating is one of the needs of the mental and physical creation , and architectural design has the intercommunication between science and creation to reach student to the creative level especially in architectural design , this research study the ...
Alan Fraidoon Ali, Chro Mohammed Ali
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

FEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu, Yanan Wei, Zekun Wu, Tianmu Zhang, DoHoon Lee, Hadi Najafi, Woo Jae Kim   +6 more
wiley   +1 more source

Engineering Approaches for Programming Agent-Based IoT Objects Using the Resource Management Architecture [PDF]

, 2021
Fabian César Pereira Brandão Manoel, Maria Alice Trinta, Carlos Eduardo Pantoja, Jean Zahn, José Viterbo   +4 more
openalex   +1 more source

The Architectural Implications of Autonomous Driving: Constraints and Acceleration

International Conference on Architectural Support for Programming Languages and Operating Systems, 2018
Autonomous driving systems have attracted a significant amount of interest recently, and many industry leaders, such as Google, Uber, Tesla, and Mobileye, have invested a large amount of capital and engineering power on developing such systems.
Shi-Chieh Lin, Yunqi Zhang, Chang-Hong Hsu, Matt Skach, Md E. Haque, Lingjia Tang, Jason Mars   +6 more
semanticscholar   +1 more source