Results 31 to 40 of about 32,757 (262)

Kritisk empiri. Ett historiografiskt perspektiv

open access: yesNordlit: Tidsskrift i litteratur og kultur, 2015
The article discusses the possible value of a ”critical empiricism” as the forgotten ”other” of the well-established critical theory. Following Swedish sociologist Johan Asplund, critical empiricism is described as ”seeing what others have not seen”. The
Claes Caldenby
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Brutalism, Film, and Dystopia: The Many (Cinematic) Lives of John Andrews’s Scarborough College

open access: yesRA. Revista de Arquitectura, 2023
Since its opening to the public in 1965, John Andrews’s megastructure Scarborough College —currently University of Toronto, Scarborough— has received universal acclaim.
Luis-Miguel Lus-Arana   +2 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Ivan Karlov’s “Tsaritsyn Anabasis

open access: yesВестник Волгоградского государственного университета. Серия 4. История, регионоведение, международные отношения, 2017
This paper acquaints the historians with a curious incident that took place in Suzdal in 1674. The present case surprisingly resembles a well-known plot twist of Jaroslav Hašek’s novel The Fateful Adventures of the Good Soldier Švejk During the World War
Matvei I. Davydov
doaj   +1 more source

The hedonistic sustainability concept in the works of Bjarke Ingels

open access: yesARTEKS : Jurnal Teknik Arsitektur, 2020
Contemporary architects highlight past ideas and present new manifestos often perceived as utopian. Bjarke Ingels introduced hedonistic sustainability in response to the demand for environmentally friendly and sustainable living through different ...
Nita Dwi Estika   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

From Picturesque Landscapes to Brand-new Cities: A Survey for Understanding the Effects of Protective Structures on Visitor Impression

open access: yesProceedings of the International Conference of Contemporary Affairs in Architecture and Urbanism-ICCAUA, 2022
In order to prevent the deterioration of immovable architectural artefacts unearthed in archaeological sites, it is observed that protective structures are applied.
Büşra Ceylan, Nihan Kocaman Pavlovic
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

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