Results 31 to 40 of about 32,757 (262)
Kritisk empiri. Ett historiografiskt perspektiv
The article discusses the possible value of a ”critical empiricism” as the forgotten ”other” of the well-established critical theory. Following Swedish sociologist Johan Asplund, critical empiricism is described as ”seeing what others have not seen”. The
Claes Caldenby
doaj +1 more source
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Brutalism, Film, and Dystopia: The Many (Cinematic) Lives of John Andrews’s Scarborough College
Since its opening to the public in 1965, John Andrews’s megastructure Scarborough College —currently University of Toronto, Scarborough— has received universal acclaim.
Luis-Miguel Lus-Arana +2 more
doaj +1 more source
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Ivan Karlov’s “Tsaritsyn Anabasis
This paper acquaints the historians with a curious incident that took place in Suzdal in 1674. The present case surprisingly resembles a well-known plot twist of Jaroslav Hašek’s novel The Fateful Adventures of the Good Soldier Švejk During the World War
Matvei I. Davydov
doaj +1 more source
The hedonistic sustainability concept in the works of Bjarke Ingels
Contemporary architects highlight past ideas and present new manifestos often perceived as utopian. Bjarke Ingels introduced hedonistic sustainability in response to the demand for environmentally friendly and sustainable living through different ...
Nita Dwi Estika +3 more
doaj +1 more source
Diversity and complexity in neural organoids
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
In order to prevent the deterioration of immovable architectural artefacts unearthed in archaeological sites, it is observed that protective structures are applied.
Büşra Ceylan, Nihan Kocaman Pavlovic
doaj +1 more source
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source

