Results 41 to 50 of about 9,070,680 (243)

Ivan Karlov’s “Tsaritsyn Anabasis

open access: yesВестник Волгоградского государственного университета. Серия 4. История, регионоведение, международные отношения, 2017
This paper acquaints the historians with a curious incident that took place in Suzdal in 1674. The present case surprisingly resembles a well-known plot twist of Jaroslav Hašek’s novel The Fateful Adventures of the Good Soldier Švejk During the World War
Matvei I. Davydov
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Kritisk empiri. Ett historiografiskt perspektiv

open access: yesNordlit: Tidsskrift i litteratur og kultur, 2015
The article discusses the possible value of a ”critical empiricism” as the forgotten ”other” of the well-established critical theory. Following Swedish sociologist Johan Asplund, critical empiricism is described as ”seeing what others have not seen”. The
Claes Caldenby
doaj   +1 more source

The hedonistic sustainability concept in the works of Bjarke Ingels

open access: yesARTEKS : Jurnal Teknik Arsitektur, 2020
Contemporary architects highlight past ideas and present new manifestos often perceived as utopian. Bjarke Ingels introduced hedonistic sustainability in response to the demand for environmentally friendly and sustainable living through different ...
Nita Dwi Estika   +3 more
doaj   +1 more source

Prospecting the protein design landscape

open access: yesFEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona   +4 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

Architectural Criticism between Public Debate and Autonomous Discipline (3)

open access: yes, 2016
Mapping the reception of Victor Horta: the blurring boundaries of architectural criticism, theory and history Dirk Van de Vijer Associate professor, Department of History of Art, Utrecht University From 1895 to 1905, Horta stood at the peak of his fame ...
Mapping Architectural Criticism
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

open access: yesFEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward   +2 more
wiley   +1 more source

Giacomo Boni at the Antiquarium Forense : construction history as a source for architectural innovation

open access: yes, 2006
This paper discusses construction history as a source for architectural innovation by analysing the early 20th century intervention of Giacomo Boni at the monastery of Santa Francesca ...
Gonzalez-Longo, Cristina
core   +3 more sources

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

open access: yesFEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana   +3 more
wiley   +1 more source

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